Increase in mRNAs encoding neonatal II and III sodium channel α-isoforms during kainate-induced seizures in adult rat hippocampus

Gastaldi, Marguerite; Bartolomei, Fabricē; Massacrier, Annick; Planells, Richard; Robaglia-Schlupp, Andrée; Cau, Pierre

doi:10.1016/s0169-328x(96)00199-4

Cited by 56 publications

(44 citation statements)

References 42 publications

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“…These memory-related synchronisation changes are interindividually correlated with increases of rhinal-hippocampal theta (4)(5)(6)(7) coherence (2). However, a pronounced broad-band rhinal-hippocampal coupling, including the gamma range, is only observed for words with a high frequency of occurrence (common words), but not for rare words (3).…”

Section: Mediotemporal Connectivity and Declarative Memory J Fell Cmentioning

confidence: 95%

“…However, a pronounced broad-band rhinal-hippocampal coupling, including the gamma range, is only observed for words with a high frequency of occurrence (common words), but not for rare words (3). Compared to the waking state ongoing rhinal-hippocampal coherence decreases during sleep, most pronounced within the gamma-band (4). Finally, we detected that ongoing rhinal-hippocampal coherence is more than twice as large for patients with good dream memory compared to patients with poor dream memory (5).…”

Section: Mediotemporal Connectivity and Declarative Memory J Fell Cmentioning

confidence: 96%

“…It is known from animal models that i) seizures may induce a dynamic shift in the alternative splicing of Na + -channels and that ii) an alternative splicing of sodium channel genes can result in marked functional differences of the finally displayed sodium current (2)(3)(4). Tate et al (5,6) have recently investigated a polymorphism in the human SCN1A gene (a sodium-channel gene) in the consensus 5 splice donor site of a highly conserved, alternatively spliced exon.…”

Section: Session: Pharmacogenetics 2 Pharmacogenetics Of Antiepileptimentioning

confidence: 99%

“…Considering this evidence basis all further studies will have to use one of these standard therapies (4).…”

Section: Abstracts Of the 5th Joint Meetingmentioning

confidence: 99%

“…The second study regarding the in house treatment of SE found that control of SE within 20 minutes occurs significantly less frequently after phenytoin (18 mg/kg) monotherapy (3) as compared to 3 others standard therapies: a) lorazepam (0,1 mg/kg), b) phenobarbitol (15 mg/kg), and c) diazepam (0,15 mg/kg) followed by phenytoin (18 mg/kg). Most other evidence we have in the treatment of SE is obtained by observational studies/case series, underpowered "pilot studies" and expert opinion (4).…”

Section: Innate Immunity In Epilepsy a Vezzani Mario Negri Institutementioning

confidence: 99%

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Abstracts of the 5th Joint Meeting of the German, Austrian, and Swiss Sections of the International League Against Epilepsy Basle, May 16?19, 2007

2007

Epilepsia

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Goals, methodology:Epilepsy surgery is defined as any neurosurgical intervention with the primary goal to relieve intractable epilepsy. On the other hand essential brain regions like primary motor and sensory cortex as well as brain areas supporting language and memory functions have to be spared to avoid neurological deficits caused by the operation. Thus, the exact localization of the epileptogenic zone and of essential brain regions is crucial for the successful surgical treatment of seizures that can only be accomplished during a thorough presurgical work-up. A new noninvasive brain mapping procedure magnetoencephalography (MEG) was employed during the presurgical evaluation for localization of the epileptogenic zones and for the determination of hemispheric dominance and intrahemispheric localization of linguistic functions in patients with drug-resistant focal epilepsies.Results: The role of MEG for the localization of the epileptogenic zone in the noninvasive evaluation of patients with focal drug-resistant epilepsies:We evaluated the sensitivity and selectivity of interictal MEG versus prolonged ictal and interictal scalp video-EEG in order to identify patient groups that would benefit from preoperative MEG testing. One hundred thirteen consecutive patients with medically refractory epilepsy who underwent surgery were included. The epileptogenic region predicted by interictal and ictal Video-EEG (V-EEG) and MEG was defined in relation to the resected area as perfectly overlapping with the resected area, partially overlapping, or nonoverlapping. Using MEG, we were able to localize the resected region in a greater proportion of patients (72.3%) than with noninvasive V-EEG (40%). MEG contributed to the localization of the resected region in 58.8% of the patients with a nonlocalizing V-EEG study and 72.8% of the patients for whom V-EEG only partially identified the resected zone. Overall, MEG and V-EEG results were equivalent in 32.3% of the cases, and additional localization information was obtained using MEG in 40% of the patients. MEG was most useful for presurgical planning in patients who had either partially or nonlocalizing V-EEG results.Functional organization of interictal spike complex in medial temporal lobe epilepsies:Thirty patients with mesial temporal lobe epilepsy (MTLE) using combined MEG and EEG recordings were icluded. Spikes could be recorded in 14 patients (47%) during the 2-to 3-h MEG/EEG recording session. The MEG and EEG spikes were subjected to separate dipole analyses and the spike dipole localizations were superimposed on MRI scans. All spike dipoles could be localized to the temporal lobe with a clear preponderance in the medial region. Based on dipole orientations in MEG, patients could be classified into two groups: patients with anterior medial vertical (AMV) dipoles, suggesting epileptic activity in the mediobasal temporal lobe and patients with anterior medial horizontal (AMH) dipoles, indicating involvement of the temporal pole and the anterior parts of the lateral temporal ...

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Section: Mediotemporal Connectivity and Declarative Memory J Fell Cmentioning

confidence: 95%

Section: Mediotemporal Connectivity and Declarative Memory J Fell Cmentioning

confidence: 96%

Section: Session: Pharmacogenetics 2 Pharmacogenetics Of Antiepileptimentioning

confidence: 99%

“…Considering this evidence basis all further studies will have to use one of these standard therapies (4).…”

Section: Abstracts Of the 5th Joint Meetingmentioning

confidence: 99%

Section: Innate Immunity In Epilepsy a Vezzani Mario Negri Institutementioning

confidence: 99%

See 3 more Smart Citations

Abstracts of the 5th Joint Meeting of the German, Austrian, and Swiss Sections of the International League Against Epilepsy Basle, May 16?19, 2007

2007

Epilepsia

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Distribution of voltage-gated sodium channel ?-subunit and ?-subunit mRNAs in human hippocampal formation, cortex, and cerebellum

et al. 2000

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Combining sodium MRI, proton MR spectroscopic imaging, and intracerebral EEG in epilepsy

AZILINON

Makhalova

Zaaraoui

et al. 2022

Human Brain Mapping

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Whole brain ionic and metabolic imaging has potential as a powerful tool for the characterization of brain diseases. We combined sodium MRI ( 23 Na MRI) and 1 H-MR Spectroscopic Imaging ( 1 H-MRSI), assessing changes within epileptogenic networks in comparison with electrophysiologically normal networks as defined by stereotactic EEG (SEEG) recordings analysis. We applied a multi-echo density adapted 3D projection reconstruction pulse sequence at 7 T ( 23 Na-MRI) and a 3D echo-planar spectroscopic imaging sequence at 3 T ( 1 H-MRSI) in 19 patients suffering from drugresistant focal epilepsy who underwent presurgical SEEG. We investigated 23 Na MRI parameters including total sodium concentration (TSC) and the sodium signal fraction associated with the short component of T 2 * decay (f), alongside the level of metabolites N-acetyl aspartate (NAA), choline compounds (Cho), and total creatine (tCr). All measures were extracted from spherical regions of interest (ROIs) centered between two adjacent SEEG electrode contacts and z-scored against the same ROI in controls.Group comparison showed a significant increase in f only in the epileptogenic zone (EZ) compared to controls and compared to patients' propagation zone (PZ) and noninvolved zone (NIZ). TSC was significantly increased in all patients' regions compared to controls. Conversely, NAA levels were significantly lower in patients compared to controls, and lower in the EZ compared to PZ and NIZ. Multiple regression analyzing the relationship between sodium and metabolites levels revealed significant relations

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Increase in mRNAs encoding neonatal II and III sodium channel α-isoforms during kainate-induced seizures in adult rat hippocampus

Cited by 56 publications

References 42 publications

Abstracts of the 5th Joint Meeting of the German, Austrian, and Swiss Sections of the International League Against Epilepsy Basle, May 16?19, 2007

Abstracts of the 5th Joint Meeting of the German, Austrian, and Swiss Sections of the International League Against Epilepsy Basle, May 16?19, 2007

Distribution of voltage-gated sodium channel ?-subunit and ?-subunit mRNAs in human hippocampal formation, cortex, and cerebellum

Combining sodium MRI, proton MR spectroscopic imaging, and intracerebral EEG in epilepsy

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