Increase in Ischemic Stroke Incident Hospitalizations Among Bedouin Arabs During Ramadan Month

Zimhony, Noa; Abu-Salameh, Ibrahim; Sagy, Iftach; Dizitzer, Yotam; Oxman, Liat; Yitshak‐Sade, Maayan; Novack, Victor; Horev, Anat; Ifergane, Gal

doi:10.1161/jaha.117.008018

Cited by 9 publications

(13 citation statements)

References 32 publications

(51 reference statements)

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“…Given that the mortality rate can change during the Ramadan (Abazid et al 2018;Zimhony et al 2018), another model was developed to adjust for the effect of this month. In this model that was similar to the main model, only a binary (0 and 1) variable of not-Ramadan or Ramadan were introduced to control for the possible effect of any changes in mortality rate.…”

Section: Discussionmentioning

confidence: 99%

Association of short-term exposure to air pollution with mortality in a middle eastern tourist city

Khosravi

Hadei

Hopke

et al. 2020

Air Qual Atmos Health

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This study investigated the association of short-term exposure to PM 10 , PM 2.5 , NO 2 , O 3 , and CO with daily all-cause, cardiovascular, ischemic heart disease (IHD), cerebrovascular, and respiratory deaths in Mashhad, a tourist megacity in Iran (2014Iran ( -2018. A distributed-lag-day, nonlinear model (DLNM) and generalized additive model (GAM) based on the quasi-Poisson distribution were used to explore the exposure-lag-day-response associations. The average (± standard deviation) concentrations of PM 10 , PM 2.5 , NO 2 , O 3 , and CO were 67.1 (± 35.5), 29.6 (± 14.2), 57.3 (± 24.1), 55.9 (± 16.9), and 1907.6 (± 1362.7) μg/m 3 , respectively. NO 2 was associated with IHD mortality in lag-days 0 to 0-7, and lag-day 1. The relative risks (RRs) for a 10 μg/m 3 increase in NO 2 ranged from 1.01 (95% CI 0.93, 1.11) at lag-day 0 to 1.04 (95% CI 0.94, 1.16) and 1.03 (95% CI 0.93, 1.14) for lag-day 0-1 (cumulative) and lag-day 1 (non-cumulative), respectively. For all-cause mortality, cumulative exposure to PM 2.5 for lag-day 0-7 (1.07, 95% CI 1.00, 1.15) and non-cumulative exposure to NO 2 at lag-day 6 (1.02, 95% CI 1.00, 1.03) were significant. Exposure to PM 10 (per 10 μg/m 3 ) was significantly associated with respiratory mortality at several lag-days. Adjusting for Ramadan did not significantly affect the results. PM 10 had significant associations with respiratory mortality of people > 65 years old, and men for several lag-days. For IHD, NO 2 affected older people, and men and women over different lagdays. Results of multi-pollutant models were similar to the single-pollutant model outcomes. In conclusion, NO 2 and PM 10 had more significant relationships with adverse health outcomes than the other pollutants.

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Section: Discussionmentioning

confidence: 99%

Association of short-term exposure to air pollution with mortality in a middle eastern tourist city

Khosravi

Hadei

Hopke

et al. 2020

Air Qual Atmos Health

View full text Add to dashboard Cite

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“…For some patients with it under serious situation, only surgical treatment is selectable, but the prognosis of patients after surgery is not optimistic [ 8 ]. Dysfunction of cerebral supplying arteries is known as the cause of CIS, but its definite development remains unclear [ 9 ]. Therefore, domestic and foreign researchers are working hard to probe into the mechanism of CIS molecularly to find a novel and effective therapy scheme.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-155 influences cell damage in ischemic stroke via TLR4/MYD88 signaling pathway

2021

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Cerebral ischemic stroke (CIS) is extremely harmful, and its treatment should be underpinned by understanding its pathogenic mechanism. This study was designed to determine the involvement of miR-155 in CIS development via the TLR4/MyD88 signaling pathway. First, we quantified serum miR-155 in patients with CIS and healthy individuals, and found high expression of miR-155 in such patients and a decrease in it in the patients after therapy (P < 0.05). Serum miR-155 demonstrated a favorable function in predicting the development and prognosis of CIS (P < 0.001). We also conducted a mouse assay, and found that knocking out miR-155 can improve the neurological function of mice and suppress protein TLR4 and MyD88 (all P < 0.05). Finally, we carried out a cell assay, and found enhancement in the activity of SH-SY5Y cells, decrease in their apoptosis, and protein TLR4 and MyD88 in them after suppression of miR-155 (all P < 0.05). Furthermore, we also found complete reverse by TLR4/MyD88 pathway inhibitor on the influence of increasing miR-155 on cells (P > 0.05). Therefore, with an increase in cases with CIS, miR-155 takes a part in the development of cell damage by activating TLR4/MyD88, and it is probably the key to diagnosing and treating CIS.

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“…There are several previous reports about metabolic changes related to fasting, such as weight loss and dehydration [4,5]. Those changes may primarily affect individuals with diabetes [6], but there are also reports that Ramadan fasting may cause hypertension [7] and increase the incidence of ischaemic stroke [8]. However, for healthy individuals, the metabolic changes that occur are unlikely to have significant harmful consequences [9,10].…”

Section: Introductionmentioning

confidence: 99%

Does fasting during Ramadan increase the risk of the development of sialadenitis?

et al. 2020

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Background: Ramadan is a month within the Islamic lunar calendar when Muslims are required to fast (abstain from food and drink) during the daytime (from sunrise to sunset) for the entire month. Due to the established connection between fasting and dehydration and acute sialadenitis, the aim of this study is to determine if there is a higher frequency of sialadenitis among the Muslim population during Ramadan than during other months of the year. Methods: We conducted a retrospective study using the medical records of 120 Muslim patients admitted to the emergency room (ER) and diagnosed with acute sialadenitis over a 5-year period at the Baruch Padeh Medical Center, Poriya, and St. Vincent de Paul (French) Hospital, Nazareth, both located in Israel. The study group were Muslim patients, with the aforementioned diagnosis, admitted during Ramadan, while the control group included patients diagnosed with sialadenitis during the rest of the year. We analyzed overall admission frequency as well as descriptive and diagnostic data, including age, sex, gland involved and several blood test results. Results: During the month of Ramadan, the admission of Muslims with a diagnosis of acute sialadenitis was more than double that during the other months of the yeara difference that was found to be statistically significant (p = 0.001). Additionally, we found that Ramadan sialadenitis patients had significantly higher leukocyte numbers at admission (p = 0.0085) and, importantly, a significantly higher level of dehydration (blood urea nitrogen (BUN)/ creatinine ratio) than non-Ramadan sialadenitis patients (p = 0.0001). Conclusion: There is evidence that fasting in Ramadan may increase the risk for the development of acute sialadenitis. Our results suggest that this may be the result of dehydration.

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Increase in Ischemic Stroke Incident Hospitalizations Among Bedouin Arabs During Ramadan Month

Cited by 9 publications

References 32 publications

Association of short-term exposure to air pollution with mortality in a middle eastern tourist city

Association of short-term exposure to air pollution with mortality in a middle eastern tourist city

MicroRNA-155 influences cell damage in ischemic stroke via TLR4/MYD88 signaling pathway

Does fasting during Ramadan increase the risk of the development of sialadenitis?

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