Increase in free radical generation and lipid peroxidation following chemotherapy in patients with cancer

Sangeetha, P.; Das, Undurti N.; Koratkar, Revati; Suryaprabha, P.

doi:10.1016/0891-5849(90)90139-a

Cited by 217 publications

(138 citation statements)

References 11 publications

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“…1987: Oberley. 1990: Sangeetha et al 1990. it can be hypothesized that a relatively high Mn-SOD level of the colorectal carcinomas in our study contributes to tumour cell resistance and therapy insensitivity resulting in a poor clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

Superoxide dismutases in relation to the overall survival of colorectal cancer patients

Janssen

Bosman²,

Sier³

et al. 1998

Br J Cancer

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Summary Reactive oxygen metabolites are implicated in the initiation and promotion of cancer. In addition, oxidant scavengers, such as manganese -(Mn-SOD) and copper/zinc -superoxide dismutase (Cu/Zn-SOD), are thought to contribute to colorectal cancer treatment response. In the present study, the prognostic significance of the Mn-and Cu/Zn-SOD antigen content of normal mucosa and carcinomas of 163 patients with colorectal cancer was evaluated in comparison with major clinicopathological parameters, with respect to the 5-year overall survival. The Mn-SOD content of carcinomas was found to be significantty higher than that of normal mucosa, whereas there was no difference in the Cu/Zn-SOD content between the normal mucosa and carcinomas. No association was demonstrable between the Mn-SOD and Cu/Zn-SOD content of the tissues and the assessed clinicopathological parameters (gender, age, localization, differentiation grade, diameter and Dukes' stage), with the exception of the Cu/Zn-SOD and the differentiation grade of the carcinomas. Univariate analysis showed that a high Mn-SOD content of carcinomas was associated with a poor 5-year overall survival of the patients with colorectal cancer. Multivariate analysis including all clinicopathological parameters revealed that this Mn-SOD parameter was prognostically independent. The Mn-and Cu/Zn-SOD content of normal mucosa and the Cu/Zn-SOD content of carcinomas were not associated with the overall survival of the patients. In conclusion, this study demonstrates that for patients with colorectal cancer the Mn-SOD content of colorectal carcinomas has a significant prognostic value that is independent from major clinicopathological parameters, including Dukes' stage.

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Section: Discussionmentioning

confidence: 99%

Superoxide dismutases in relation to the overall survival of colorectal cancer patients

Janssen

Bosman²,

Sier³

et al. 1998

Br J Cancer

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“…The latter included serum bilirubin, AST, ALT, ALP, total protein and albumin concentrations estimated by standard laboratory procedures. Malonaldehyde level (as indicator of oxidative stress), was determined as thiobarbituric acid reactive substances [20] . Total plasma antioxidant capacity was determined by FRAP (Ferric oxide reducing ability of plasma) method [21] .…”

Section: Methodsmentioning

confidence: 99%

Liver Dysfunction in Pulmonary Tuberculosis Patients on DOTS: A Study and Review

Pandit

Pandey

2016

Journal of Gastroenterology and Hepatology Research

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eGFR were done. Development of hepatotoxicity was watched by monthly monitoring of liver enzymes and bilirubin serum profiles. RESULT: The selected 148 patients were older and four fifths were males. 16 patients developed ATT-DIH at first or second month monitoring following DOTS. They were more undernourished, hypoproteinaemic, bore more extensive disease and were sputum AFB positive. Their eGFR profiles were normal but significantly lower and plasma antioxidant capacity significantly reduced. Oxidative stress marker levels also were insignificantly raised. They exhibited subclinical elevation of serum enzymes AST and ALT. No significant influence of age and gender was seen on incidence of ATT-DIH. CONCLUSION: Frailty with extensive disease constituted phenotype vulnerable to ATT-DIH. Hypoalbuminaemia, reduced plasma antioxidant capacity, subclinical elevated profile of transaminases before starting DOTS were forewarning laboratory indices. LFT ought to be monitored at fortnight, a month and at 2 months in such patients as minimum necessity to timely detect and address hepatotoxicity. INTRODUCTIONTuberculosis continues as huge health care problem globally. Currently recommended first line treatment for TB includes regimen of isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA) and ethambutol (EMB) for initial 2 months followed by 4 months of INH and RMP and/or EMB [1] . Among the first line quadruple therapy drugs (INH, RMP, PZA, EMB), first three are metabolized mainly by the liver and are potentially hepatotoxic. A fair fraction of TB patients on chemotherapy with isoniazide and rifampicin exhibit elevations in serum levels of liver enzymes, alanine aminotransferase (ALT, earlier called SGPT) and aspartate aminotransferase (AST, earlier SGOT) activities. A small fraction of these can worsen further to compel ABSTRACT CONTEXT: Phenomenal number of people suffers tuberculosis and is prescribed primary line DOTS antitubercular chemotherapy. Evidence based clinical practice to minimize risk of hepatotoxicity is primary imperative. AIM: Study generates evidence for predicting individual hepatotoxic risk using patient's constitutional and health parameters and disease characteristics and adopting right course of management. It is observational study in patients consecutively selected by defined inclusion and exclusion criteria. METHODS: Newly enrolled pulmonary tuberculosis patients for DOTS were studied to examine host and disease specific predictors of hepatotoxicity risk. Pretreatment baseline liver function tests and

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“…However, PUFA are highly susceptible to oxidation during storage, which creates various aldehydes and ketones products that render unacceptable odor and flavor in PUFA containing foods (McClements & Decker, 2008). In addition, lipid oxidation products, such as lipid peroxides, unsaturated aldehydes and malonaldehydes, and several cholesterol oxidation products (Sangeetha, Das, Koratkar, & Suryaprabha, 1990;Esterbauer, Schaur, & Zollner, 1990;Addis, 1986) have a negative impact on human health due to their cytotoxic and genotoxic effects (Kanner, 2007;Fang, Vaca, Valsta, & Mutanen, 1996). The rate of oxidation of PUFA can be retarded decreased by the addition of many synthetic or natural antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Effects of xanthan–locust bean gum mixtures on the physicochemical properties and oxidative stability of whey protein stabilised oil-in-water emulsions

et al. 2015

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Increase in free radical generation and lipid peroxidation following chemotherapy in patients with cancer

Cited by 217 publications

References 11 publications

Superoxide dismutases in relation to the overall survival of colorectal cancer patients

Superoxide dismutases in relation to the overall survival of colorectal cancer patients

Liver Dysfunction in Pulmonary Tuberculosis Patients on DOTS: A Study and Review

Effects of xanthan–locust bean gum mixtures on the physicochemical properties and oxidative stability of whey protein stabilised oil-in-water emulsions

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