Increase in Circulating Products of Lipid Peroxidation (F₂-Isoprostanes) in Smokers — Smoking as a Cause of Oxidative Damage

Abstract

The increased levels of F2-isoprostanes in the circulation of persons who smoke support the hypothesis that smoking can cause the oxidative modification of important biologic molecules in vivo.

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

“…Smoking may enhance the effect of ROS in periodontitis, thereby increasing the tissue destruction resulting from oxidative stress, which may lead to higher lipid peroxidation. Increased circulating products of lipid peroxidation (F 2 -isoprostanes) in smokers have been documented and observed that smoking causes oxidative modification of biologic compounds in humans [43]. Similar observations of higher MDA among the smokers are also documented by studies [36,42], which is in accordance to our finding.…”

“…It is therefore quite possible that periodontitis causes lower plasma vitamin C through this mechanism [39]. In this study serum vitamin C level was lower in chronic periodontitis as compared to healthy controls, which was also documented by [40,41].Smokers are constantly over exposed to free radicals through inhalation of long lived carbon and oxygen centered radicals that subsequently deplete the plasma antioxidant vitamin C. Similar to our study, studies [42,43] have reported lower vitamin C levels in smokers than in non-smokers.…”

Systemic elevations of free radical oxidation products of arachidonic acid are associated with angiographic evidence of coronary artery disease

“…In our study, of the multiple free radical lipid oxidation products monitored, only 9-HETE and F 2 -Isoprostane levels were significantly associated with the presence of CAD, even after adjustment for Framingham risk score and CRP. Remarkably, this association was observed despite multiple corrections for known cardiac risk factors, since prior studies demonstrate levels of F 2 -Isoprostane are elevated in conditions like smoking and hyperlipidemia [35][36][37]. Further studies focusing on interval changes and links to outcomes with F 2 -Isoprostane and 9-HETE are warranted.…”

Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women

“…High levels of reactive oxygen species can promote lipid peroxidation, damage cells, and contribute to chronic diseases, including cancer (Ames et al, 1993). Morrow et al (1995) identified the F 2 -isoprostanes, prostaglandin-like compounds produced by free radical-induced peroxidation of arachidonic acid that can be measured in plasma and urine. This group demonstrated that F 2 -isoprostanes were superior to other biomarkers used as indices of lipid peroxidation in vivo, including malondialdeyde (MDA) (Longmire et al, 1994).…”

“…This group demonstrated that F 2 -isoprostanes were superior to other biomarkers used as indices of lipid peroxidation in vivo, including malondialdeyde (MDA) (Longmire et al, 1994). Levels of F 2 -isoprostanes in body fluids are elevated by conditions that are thought to be associated with free radical-induced oxidative stress, including smoking (Morrow et al, 1995;Reilly et al, 1996), hypercholesterolemia (Davi et al, 1997;Reilly et al, 1998;Palombo et al, 1999), diabetes (Davi et al, 1999), and acute and chronic alcoholic liver disease Meagher et al, 1999). Recent research suggests a role for oxidative stress in breast cancer (Kumar et al, 1991;Thangaraju et al, 1994;Li et al, 1999;Novak & Woodcroft, 2000;Ray et al, 2000).…”