Increase in Ceftriaxone Resistance and Widespread Extended-Spectrum β-Lactamases Genes Among <i>Salmonella enterica</i> from Human and Nonhuman Sources

Kuang, Dai; Zhang, Jianmin; Xu, Xuebin; Shi, Weimin; Yang, Xiaowei; Su, Xudong; Shi, Xianming; Meng, Jianghong

doi:10.1089/fpd.2018.2468

Cited by 13 publications

(15 citation statements)

References 33 publications

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“…It is noted that the serovars presented a number of isolates that were lower than or equal to five were not taken for this comparison and discussion. Additionally, our results showed the resistance of ESBLs-producing strains to other non-β-lactam antimicrobial categories, with high resistance not only to cephalosporins and penicillins but also to aminoglycosides and sulphonamides, which was consistent with other studies demonstrating that ESBLs+ strains are often multidrug resistant [48]. Importantly, the antimicrobial resistance of ESBLs+ bacteria is significantly more serious than that of ESBLs-bacteria.…”

Section: Discussionsupporting

confidence: 92%

“…ESBLs have a wide range of enzyme activities and can hydrolyze penicillin, first-or second-generation cephalosporins, and broad-spectrum cephalosporins containing oxime groups, including third-generation cephalosporins such as ceftazidime, cefotaxime, ceftriaxone, and cefixime as well as fourthgeneration cephalosporin-like cefepime, and can also hydrolyze monobactams such as aztreonam [46]. Recent studies around the world indicate that the prevalence of ESBLsproducing strains is increasing each year [5,[47][48][49]. In our study, the prevalence of ESBLsproducing strains was 21.67%, which was lower than that found in retail chicken in Henan province in 2017 (50.0%) [5].…”

Section: Discussionmentioning

confidence: 99%

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Antimicrobial Resistance Profiles and Genetic Typing of Salmonella Serovars from Chicken Embryos in China

Zhou

Jiang

et al. 2021

Antibiotics

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Salmonella continues to be a major food and public health burden worldwide that can threaten human health via eating contaminated meats, particularly those originating from chicken. In this study, the antimicrobial resistance profiles, epidemiological characteristics of resistance genes, and pulsed field gel electrophoresis (PFGE-XbaI) typing of 120 non-Pullorum/Gallinarum Salmonella isolates recovered from chicken embryos in Henan province were determined. The antimicrobial resistant phenotypes and evaluation of the extended-spectrum beta-lactamases (ESBLs) producing strains of Salmonella were investigated by the Kirby–Bauer test and the double-disk synergy test. Additionally, 37 antimicrobial resistance genes encoding resistance to five different categories, including aminoglycosides, cephalosporins, sulphonamides, tetracyclines, and β-lactams, were examined by conventional PCR. However, genotyping analysis was conducted by macro-restriction using enzyme XbaI followed by the separation of the restricted DNA fragments by PFGE. The results of this study showed that the studied Salmonella strains were highly resistant to ampicillin (66.67%) and sulfisoxazole (66.67%), while they were all susceptible to meropenem, imipenem, colistin, and chloramphenicol. Additionally, 67.5% (81/120) of the studied strains were multidrug resistant, and 21.67% (26/120) were phenotypically confirmed as ESBLs positive. The statistical analysis showed that resistance depends on the serovars, and ESBLs positive strains showed more multi-resistance than ESBLs negative strains (p < 0.05). The genotypic antimicrobial resistance showed the detection of 14 among the 37 tested genes, and the concordance between genotypic and phenotypic antimicrobial resistance ranged from 0% to 100% depending on the serovars. However, the PFGE-XbaI typing results showed that the examined Salmonella strains were divided into 22 individual subtypes and were grouped in nine clusters, with similarity values ranging from 64.7% to 100%. From this study, we can conclude that the antimicrobial resistance of Salmonella serovars isolated from chicken embryos in Henan province was alarming, with rigorous multidrug resistance, which requires the urgent mitigation of the use of antimicrobial drugs in chicken hatcheries. Additionally, our results showed evidence of the presence of different PFGE patterns among the studied Salmonella serovars, suggesting the presence of different sources of contamination.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance Profiles and Genetic Typing of Salmonella Serovars from Chicken Embryos in China

Zhou

Jiang

et al. 2021

Antibiotics

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“…The study report from Jimma University Specialized Teaching Hospital also reported that the rate of bacterial isolates resistant to ceftriaxone was more than 50%, whereas about 44% of ceftriaxone‐resistant bacterial strains were found to be resistant to two or more drugs 3 . Similar studies from Shanghai, China also reported that increasing ceftriaxone‐resistant salmonella strains were found to be multidrug resistant 31 . The ever‐increasing AMR to first‐line antibiotics including third‐generation cephalosporins is associated with increased risk of invasive diseases, longer hospitalization, increased rate of morbidity and mortality, and to the worst scenario the arise of strains that could be resistant to all available treatment options 12 …”

Section: Historical Perspectives Of Ceftriaxone Resistancementioning

confidence: 75%

“… 3 Similar studies from Shanghai, China also reported that increasing ceftriaxone‐resistant salmonella strains were found to be multidrug resistant. 31 The ever‐increasing AMR to first‐line antibiotics including third‐generation cephalosporins is associated with increased risk of invasive diseases, longer hospitalization, increased rate of morbidity and mortality, and to the worst scenario the arise of strains that could be resistant to all available treatment options. 12 …”

Section: Historical Perspectives Of Ceftriaxone Resistancementioning

confidence: 99%

The contribution of nano‐based strategies in overcoming ceftriaxone resistance: a literature review

Yayehrad

Marew

Birhanu

2021

Pharmacology Res & Perspec

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Antimicrobial drug resistance, including resistance to multiple antibiotics, is continuously increasing. According to research findings, many bacteria resistant to other antibiotics were susceptible to ceftriaxone. However, over the last few years, ceftriaxone resistance has become growing and extremely worrisome challenge to the global healthcare system and several strategies have been initiated to contain the spread of antimicrobial drug resistance. Its extended use for therapeutic or preventative measures in humans and farm animals resulted in the development and spread of resistance. Recent advances in nanotechnology also offer novel formulations based on distinct types of nanostructure particles with different sizes and shapes, and flexible antimicrobial properties. For ceftriaxone, several nanostructured formulations through conjugation, intercalation, encapsulation with lipid carrier, and polymeric films have been investigated by different groups with promising results in combating the development of resistance. This review addressed the existing knowledge and practice on the contribution of nano‐based delivery approaches in overcoming ceftriaxone resistance. Evidences have been generated from published research articles using major search electronic databases such as PubMed, Medline, Google Scholar, and Science Direct.

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“…Recent studies showed that the prevalence of ESBL-producing bacteria is increasing [ 64 , 65 ]. In the present study, ESBL positivity was detected in 8.5% (8/94) of the Salmonella strains from one native breed in a breeder farm.…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis between Salmonella enterica Isolated from Imported and Chinese Native Chicken Breeds

Wen-jian

Tang

et al. 2023

Microorganisms

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Salmonella enterica is considered a significant threat to the global poultry industry and public health. In recent decades, antimicrobial resistance in Salmonella enterica has attracted increasing concern throughout the world. However, limited information is available on Salmonella enterica among different breeds of breeder chickens. Thus, this study aimed to compare the prevalence, serotype distribution, emergence of extended-spectrum beta-lactamases (ESBLs), antimicrobial resistance, and genetic resistance mechanisms in Salmonella enterica among different breeds of breeder chickens. A total of 693 samples (dead embryos, cloacal swabs, water, feed, environmental swabs, and meconium of newly hatched chicks) were selected and cultured for Salmonella from four breeder chicken farms in Shandong province, China, representing one imported and three native breeds, and the isolates were further serotyped. Of the Salmonella isolates, susceptibility to 11 antimicrobials of 5 classes, ESBL screening, and the presence of 21 antimicrobial resistance genes were determined in the present study. Overall, 94 (13.6%) isolates were recovered, which were divided into 3 serotypes (Salmonella Pullorum (n = 36), Salmonella Thompson (n = 32), and Salmonella Enteritidis (n = 26)). The results showed that the prevalence of Salmonella enterica isolates from the imported breeds was higher compared with the three domestic breeds. Eight of the ninety-four isolates were ESBL-positive strains, which were recovered from a domestic breed chicken farm. These eight ESBL-producing isolates were serotyped to Pullorum. Surprisingly, Salmonella Enteritidis (S. enteritidis) and S. pullorum were simultaneously isolated from a single dead embryo observed among one native breed. Meanwhile, among the Salmonella isolates, 53.2% (50/94) were multidrug-resistant strains, and 44.7% (42/94) of the isolates presented resistance to at least five antibiotics. Nearly all of the isolates (97.9%, 92/94) were resistant to at least one antimicrobial; one isolate of S. Thompson was resistant to seven antimicrobial agents belonging to four different classes. The carriage rate of three resistance genes (tetA, tetB, and sul1) among isolates from the imported breeds (87%, 70%, and 65.2%) was higher than that in those from domestic breeds (35.2%, 36.6, and 14.1%). To our knowledge, this is the first report of ESBLs-producing Salmonella isolated from a Chinese native breed of breeder chickens. Our results also highlight that a high prevalence of multidrug-resistant Salmonella enterica contamination is widespread among different breeds of breeder chickens, which is a major risk of food-borne diseases and public health.

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Increase in Ceftriaxone Resistance and Widespread Extended-Spectrum β-Lactamases Genes Among Salmonella enterica from Human and Nonhuman Sources

Cited by 13 publications

References 33 publications

Antimicrobial Resistance Profiles and Genetic Typing of Salmonella Serovars from Chicken Embryos in China

Antimicrobial Resistance Profiles and Genetic Typing of Salmonella Serovars from Chicken Embryos in China

The contribution of nano‐based strategies in overcoming ceftriaxone resistance: a literature review

Comparative Analysis between Salmonella enterica Isolated from Imported and Chinese Native Chicken Breeds

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