Increase in Brain Pyridoxal Phosphate by Chlorpromazine

Interconversions of vitamin B6 in mammalian tissue

“…A number of drugs such as amphetamine (Bilodeau, 1965), chlorpromazine (Ebadi, 1970), reserpine, isoniazid (Vilter, 1964, birth control pills (Brown et af., 1969) In addition, detailed studies are reported on the interconversion of 14C-PN to pyridoxine phosphate (PNP), pyridoxal phosphate (PLP), pyridoxamine phosphate (PMP), pyridoxal (PL), and pyridoxamine (PM) in liver, brain, and carcass of normal male Swiss-Webster mice and the effect of marijuana or B6 depletion on the process.…”

“…Although an extensive literature exists on the enzymatic reactions catalyzed by pyridoxal phosphate and pyridoxamine phosphate, little work has been carried out on the enzymes involved in the metabolism of vitamin B6 and even less on the rates of interconversions of vitamin Be and factors which influence the metabolism and distribution of vitamin B6. A number of drugs such as amphetamine (Bilodeau, 1965), chlorpromazine (Ebadi, 1970), reserpine, isoniazid (Vilter, 1964), birth control pills (Brown et al, 1969) and marijuana, have been shown to affect either the concentration of vitamers or the enzymes of vitamin B6 metabolism. The present paper reviews data on the absorption of pyridoxine (PN) and the enzymatic reactions involved in vitamin B6 interconversions.…”