Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma

Nozoe, Tetsuo; Rikimaru, Tatsuya; Mori, Emiko; Okuyama, Tomoko; Takahashi, Ikuo

doi:10.1002/jso.20577

Cited by 51 publications

(32 citation statements)

References 10 publications

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“…In the present study, significant increases in serum concentrations of CEA and CA 19-9 in patients with colorectal and gastric cancers could provide powerful and useful information regarding the progression of these specific types of cancer, consistent with other reports (30)(31)(32)(33). Although the serum levels of MMP-9, 130-and 225-kDa gelatinolytic bands showed statistical significance similar to that exhibited by conventional tumor markers such as CEA and CA 19-9, none of them significantly correlate with CEA or CA 19-9 expression in serum.…”

Section: Discussionsupporting

confidence: 92%

Serum levels of matrix metalloproteinase-2 and -9 and conventional tumor markers (CEA and CA 19-9) in patients with colorectal and gastric cancers

Emara

Cheung

Grabowski

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, play an important role in tumor invasion and metastasis. This study aimed to determine the serum levels of MMP-2, MMP-9, 130-and 225-kDa gelatinolytic bands and conventional tumor markers, carcinoembryonic antigen (CEA) and cancer antigen (CA) 19-9, in patients with gastrointestinal cancers. The relationship between these parameters and clinicopathological factors was also studied. Methods: Sera from controls (ns19), and patients with colorectal (ns47) and gastric (ns34) cancer were collected prospectively. The gelatinolytic activities of MMP-2, MMP-9, 130-and 225-kDa bands were determined using gelatin zymography. CEA and CA 19-9 were determined using immunoradiometric assay (IRMA). Results: Serum levels of MMP-9, 130-and 225-kDa gelatinolytic bands, CEA, and CA 19-9, but not MMP-2, in colorectal and gastric cancer were significantly higher than that of controls. No significant correlation was found between histological grade or clinical stage and levels of MMP-9, 130-and 225-kDa gelatinolytic bands, which were correlated (rs0.61-0.89, p-0.005). Conclusions: Our findings suggest that zymographic determination of

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Section: Discussionsupporting

confidence: 92%

Serum levels of matrix metalloproteinase-2 and -9 and conventional tumor markers (CEA and CA 19-9) in patients with colorectal and gastric cancers

Emara

Cheung

Grabowski

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…When the LNR classification increased, the proportion of patients with preoperative serum CEA level ≥5 ng/ml increased gradually. To some extent, this was in accordance with the study of Nozoe et al (31), which demonstrated that the proportion of lymph node metastasis was significantly higher in the high-CEA group compared with that in low-CEA group (P=0.012). This association was also observed in the LODDS classification.…”

Section: Lnr N (%) Lodds N (%) ------------------------------------supporting

confidence: 92%

Log odds of positive lymph nodes is superior to the number- and ratio-based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection

Fang

Yang

et al. 2017

Molecular and Clinical Oncology

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Abstract. The metastatic lymph node status (N classification) is an important prognostic factor for patients with colorectal cancer (CRC). The aim of the present study was to evaluate and compare the prognostic assessment of three different lymph node staging methods, namely standard lymph node (pN) staging, metastatic lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) in CRC patients who undergo curative resection (R0). Data were retrospectively collected from 192 patients who had undergone R0 resection. Kaplan-Meier survival curves, Cox proportional hazards model and accuracy of the three methods (pN, LNR and LODDS) were compared to evaluate the prognostic effect. Univariate analysis demonstrated that pN, LNR and LODDS were all significantly correlated with survival (P=0.001, P<0.001 and P<0.001, respectively). The final result of the 3-step multivariate analysis demonstrated that LODDS was superior to the other two N categories. Patients in the same pN or LNR classifications may be classified into different LODDS stages with different prognoses. Thus, LODDS may be a meaningful prognostic indicator and superior to the pN and LNR classifications in CRC patients who undergo curative (R0) resection.

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“…Furthermore, CA 19-9 was a stronger prognostic factor than CEA and predicted outcomes in the Dukes' B-C subgroup (Reiter et al, 2000). Some researchers suggested that CA 19-9 should be used in combination with CEA to increase the sensitivity in detecting recurrence of colorectal cancer (Chen et al, 2005;Nozoe et al, 2006;Lin et al, 2012). Yet, this tumor marker has not been definitely evaluated in rectal cancer patients managed with preoperative CRT.…”

Section: Discussionmentioning

confidence: 99%

Carbohydrate Antigen 19-9 Levels Associated with Pathological Responses to Preoperative Chemoradiotherapy in Rectal Cancer

Yeo

Kim

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma

Abstract: Combined data of preoperative increase in CEA and CA19-9 in sera can provide a powerful and useful information to predict prognosis of patients with colorectal carcinoma.

Cited by 51 publications

References 10 publications

Serum levels of matrix metalloproteinase-2 and -9 and conventional tumor markers (CEA and CA 19-9) in patients with colorectal and gastric cancers

Serum levels of matrix metalloproteinase-2 and -9 and conventional tumor markers (CEA and CA 19-9) in patients with colorectal and gastric cancers

Log odds of positive lymph nodes is superior to the number- and ratio-based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection

Carbohydrate Antigen 19-9 Levels Associated with Pathological Responses to Preoperative Chemoradiotherapy in Rectal Cancer

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