Increase in aortic pulse wave velocity is associated with abnormal postprandial triglyceride response

Daskalova, Deliana; Kolovou, Genovefa; Panagiotakos, Demosthenes B.; Pilatis, Nektarios D.; Cokkinos, Dennis V.

doi:10.1002/clc.4960281208

Cited by 12 publications

(6 citation statements)

References 56 publications

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“…Additionally, in 45 patients who underwent a standardized fatty meal test and whose triglycerides levels were subsequently measured after 2, 4, 6 and 8 hours, it was shown that high post-challenge triglycerides correlated positively with an increase in aortic pulse wave velocity (aPWV) 6 hours after the fatty meal consumption and, specifically, a 0.88 m/s rise of aPWVA was found for a 100mg/dl increase in triglycerides. 80 Waist circumference, which is an index of central obesity, constitutes a well-recognized cardiovascular risk factor in hypertensive patients 55 and has also been reported to be associated with such conditions as, inter alia, idiopathic portal vein thrombosis, 81 asthma in children and adolescents and uncontrolled asthma in women, 82,83 non-alcoholic liver disease 84 and dementia. 85 Oka et al conducted a study including 1,505 men and 798 women who were not taking medications for diabetes or dyslipidemia.…”

Section: Nordestgaard Et Al 2007mentioning

confidence: 99%

Postprandial dysmetabolism: Too early or too late?

Pappas¹,

Kandaraki²,

Tsirona³

et al. 2016

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postprandial dysmetabolism is a postprandial state characterized by abnormal metabolism of glucose and lipids and, more specifically, of elevated levels of glucose and triglyceride (Tg) containing lipoproteins. Since there is evidence that postprandial dysmetabolism is associated with increased cardiovascular mortality and morbidity, due to macro-and microvascular complications, as well as with conditions such as polycystic ovary syndrome (pCOS) and nonalcoholic fatty liver disease (NaFlD), it is recommended that clinicians be alert for early detection and management of this condition. management consists of a holistic approach including dietary modification, exercise and use of hypoglycemic and hypolipidemic medication aiming to decrease the postprandial values of circulating glucose and triglycerides. This review aims to explain glucose and lipid homeostasis and the impact of postprandial dysmetabolism on the cardiovascular system as well as to offer suggestions with regard to the therapeutic approach for this entity. however, more trials are required to prevent or reverse early and not too late the actual tissue damage due to postprandial dysmetabolism.

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Section: Nordestgaard Et Al 2007mentioning

confidence: 99%

Postprandial dysmetabolism: Too early or too late?

Pappas¹,

Kandaraki²,

Tsirona³

et al. 2016

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“…On the other hand, an "acute" vascular response to blood lipid changes may not be noticeable for some hours. 36 …”

Section: Exercise-central Bpmentioning

confidence: 99%

Influence of Altered Blood Rheology on Ventricular-Vascular Response to Exercise

Sharman

Brown²,

Holland³

et al. 2009

Hypertension

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Abstract-Blood (or plasma) rheology is related to cardiovascular risk. Mechanisms of this association are unclear but may be partially related to impaired left ventricular (LV) function and increased central blood pressure (BP) during light activity. This study aimed to test these hypotheses. Twenty patients (14 men; aged 61Ϯ12 years) with polycythemia rubra vera (nϭ16) or hemochromatosis (nϭ4) were studied at rest and during exercise at Ϸ50% of maximal heart rate before and after venesection (500 mL; volume replaced with saline) to elicit an acute decrease in plasma viscosity at stable BP. Controls (nϭ20) underwent the same protocol with 25-mL venesection. Central BP and augmentation index were determined by tonometry. Resting LV systolic (peak longitudinal systolic strain rate and strain) and diastolic functions were determined by tissue-Doppler echocardiography. Venesection with blood volume replacement decreased viscosity (1.46Ϯ0.10 to 1.41Ϯ0.11 centipoise), protein, and hemoglobin (PϽ0.05 for all) and increased strain rate and strain (PϽ0.001 for both) in patients but not in controls (PϾ0.10 for all). There was no change in LV diastolic function (PϾ0.12 for all Key Words: blood pressure Ⅲ hemodynamics Ⅲ blood viscosity Ⅲ heart ventricles Ⅲ exercise S everal studies have demonstrated associations between blood rheological variables (eg, fibrinogen, hematocrit, blood, and plasma viscosity) and cardiovascular risk factors, including elevated blood pressure (BP), 1 raised carotid intima media thickness, 2 increased aortic pulse wave velocity, 3 incident hypertension, 4 incident cardiovascular disease, 5 and vascular and nonvascular mortality. 6 Few studies have investigated the possible mechanisms behind these associations. Recent data suggest that studying the central (ascending aortic) BP response to exercise may reveal important information relating to left ventricular (LV) function and cardiovascular risk that would otherwise be undetectable under resting conditions. 7 This could be because of the large individual variations that may exist between brachial and central systolic BPs (SBP) during exercise. 8 These changes can be seen even with light-intensity activity, similar to that of daily life. 9,10 Thus, "true" LV afterload may be significantly different between individuals with similar brachial SBP during physical activity.Using radial tonometry to estimate central BP from arterial waveforms, we found recently that men with hypercholesterolemia had significantly elevated augmentation index (AIx) and blunted pulse pressure amplification (ratio of brachial: central pulse pressure) during light exercise. 11 This was representative of increased central systolic loading (possibly affecting normal LV function) and occurred despite similar brachial SBP compared with controls. We hypothesized that this abnormal response may be related to plasma rheology, including factors such as increased viscosity, which may retard peripheral blood runoff and increase exercise AIx. The aim of this current study was to determi...

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“…To which degree the small difference in plasma triglycerides can influence the PWV measurements is unknown. Ingestion of a high‐fat meal increased aortic PWV in one study (Daskalova et al ., ), but this finding could not be reproduced in another investigation (Frimodt‐Moller et al ., ).…”

Section: Discussionmentioning

confidence: 74%

Differential effects of age on large artery stiffness and minimal vascular resistance in normotensive and mildly hypertensive individuals

Svendsen

Khatir

Peters

et al. 2014

Clin Physio Funct Imaging

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Large artery stiffness and small artery structural changes are both cardiovascular risk factors. Arterial stiffness increases with age and blood pressure (BP), but it is unclear in which way large artery pulse wave velocity (PWV) and peripheral vascular resistance are related and whether age has any influence. In a cross-sectional study, PWV and forearm minimum vascular resistance (Rmin ) was compared with emphasis on the impact of age. Normotensive (n = 53) and untreated hypertensive (n = 23) subjects were included based on 24-h BP measurements. Age ranged from 21 to 79 years with an even distribution from each age decade. PWV was assessed using tonometry. Forearm Rmin was measured by venous occlusion plethysmography at maximal vasodilatation induced by 10 min of ischaemia in combination with skin heating and hand grip exercise. In both normotensive and hypertensive subjects, PWV correlated significantly with age and BP. Based on median age, both groups were assigned into two equally large subgroups. Normotensive older (66 ± 7 years) and younger (35 ± 10 years) persons had different carotid-femoral PWV (7.9 ± 1.8 versus 5.7 ± 0.9 m/s, P<0.01), but similar Rmin values (3.7 ± 0.9 versus 3.6 ± 1.2 mmHg/ml/min/100 ml). Hypertensive older (63 ± 6 years) and younger (40 ± 10 years) also had different PWV (8.0 ± 1.5 versus 6.7 ± 1.1 m/s, P<0.05), but the older had lower Rmin (3.1 ± 0.8 versus 4.7 ± 2.2 mmHg/ml/min/100 ml, P<0.05). In a regression analysis adjusting for age, BP, gender and heart rate, no correlation was seen between PWV and Rmin . The data suggest that age differentially affects PWV and Rmin and that BP can increase in older persons without affecting Rmin .

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Increase in aortic pulse wave velocity is associated with abnormal postprandial triglyceride response

Cited by 12 publications

References 56 publications

Postprandial dysmetabolism: Too early or too late?

Postprandial dysmetabolism: Too early or too late?

Influence of Altered Blood Rheology on Ventricular-Vascular Response to Exercise

Differential effects of age on large artery stiffness and minimal vascular resistance in normotensive and mildly hypertensive individuals

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