Increase in Anesthetic Uptake, Excretion, and Blood Solubility in Man After Eating

Munson, Edwin S.; Eger, Edmond I.; Tham, Min K.; Embro, William J.

doi:10.1213/00000539-197803000-00013

Cited by 44 publications

(34 citation statements)

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“…2 (means -S.E.M.). Both sets of values were determined in experiments in which samples of blood from unanaesthetized volunteers were exposed to isoflurane vapour in vitro.…”

mentioning

confidence: 99%

Blood solubility of isoflurane measured by amultiple gas phase equilibration technique

et al. 1983

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“…2 (means -S.E.M.). Both sets of values were determined in experiments in which samples of blood from unanaesthetized volunteers were exposed to isoflurane vapour in vitro.…”

mentioning

confidence: 99%

Blood solubility of isoflurane measured by amultiple gas phase equilibration technique

et al. 1983

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“…The anesthetic data was based on the results in the papers by Carpenter et al [5] and Munson et al [4]. Both of these studies determined the simultaneous uptake and washout of nitrous oxide (N 2 O), enflurane, halothane, and methoxyflurane.…”

Section: Methodsmentioning

confidence: 99%

“…As a test of this approach to modeling volatile solutes, PKQuest was applied to the simultaneous uptake and washout measurements of Munson et al [4] and Carpenter et al [5] for N 2 O, enflurane, halothane, and methoxyflurane. Application of PKQuest to these simultaneous anesthetic measurements provides a stringent test of the PKQuest assumptions because only the specific partition coefficients (Kbair, etc) vary for the different gases while all the other parameters (e.g.…”

Section: Introductionmentioning

confidence: 99%

PKQuest: volatile solutes – application to enflurane, nitrous oxide, halothane, methoxyflurane and toluene pharmacokinetics

Levitt¹

2002

BMC Anesthesiol

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“…Arterial blood gas tensions were measured 2 and 4 minutes after each increase in nitrous oxide concentration in seven dogs. Recordings were made 10 minutes after the nitrous oxide was increased, the end-tidallinspired concentration ratio being 0.85-0.90 (10). After obtaining recordings at 20, 40, and GO%, the nitrous oxide was abruptly discontinued and replaced by nitrogen.…”

Section: Methodsmentioning

confidence: 99%

Gradual or Abrupt Nitrous Oxide Administration in a Canine Model of Critical Coronary Stenosis Induces Regional Myocardial Dysfunction That Is Worsened by Halothane

Dm²,

Jj³

et al. 1988

Anesthesia & Analgesia

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r abrupt nitrous oxide administration in a canine model of critical coronary stenosis induces regional myocardial dysfunction that is worsened by halothane. Anesth Analg 1988;67:81422. 71rr existence of a dose-resporise retntion betzueerr nitrous oxide concentration and regional dysfunction in cornprorriised myocardium, nnd uhether or not Iialothane-iriduced rnyocardial depression alleviated this regional dysfunction ions examined. Nitrous oxide 7uas administered to eight d o p ulitli experimentally induced left anterior descending c-orunary artery (LAD) criticol stenusis during fentanyl (ZOO p,y/kg bolus plus 1.5 pgkf'.iriiri-l) anesthesia. Tzoo modes of nitrous oxide administration zuere ernployed:,yrndziat iiri steps of 20'70 inspired, i.c., O%, 20%, 40%, and 60% inspired) arid abrupt (0-60% inspired). Regional myocardial function was assessed by soriornicrornetry. Repenal dysfunction in the compromised myocnrdium, in the furrn of postsystolic sllortenirzg (PSSI, increased aboue baselinc kzds during 40% (4.2 t 2.3% to 12.1 i 3.9%, P < 0.05) and 60% (4.2 i 2.3% to 12.5 t 3.6%, P < 0.05) inspired nitrous oxide (gradual administration) and also during abrupt 60% nitrous oxide administration (6.4 i 2.6% to 9.9 t 3.2%, P < 0.05). After abrupt 60% inspired nitrous oxide administration, halothane (0.7% inspired) ions introduced and caused decreases in mean arterial pressure (206.1 2 4.5 mm Hg to 76.2 2 5.5 mm Hg, P < 0.05) and peak LV dPldt (1700 * 250 mm Hglsec to 1100 2 ZOO mm Hglsec, P < 0.05). Halothane caused a rrinrked increase in PSS (9.9 i 3.2% to 30.8 k 12.6%, P < 0.05). T h i s nitrous oxide administration caused regional dysfunction in myocardium supplied by a critically narrozoed LAD whether administered gradually or abruptly arid at coricentrations as lotu as 40% inspired. The addition of halothane to decrease myocardial oxygen demand resulted in marked zuorsening, rather than alleviation, of regional ryocardial dysfunction.

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Increase in Anesthetic Uptake, Excretion, and Blood Solubility in Man After Eating

Cited by 44 publications

References 0 publications

Blood solubility of isoflurane measured by amultiple gas phase equilibration technique

Blood solubility of isoflurane measured by amultiple gas phase equilibration technique

PKQuest: volatile solutes – application to enflurane, nitrous oxide, halothane, methoxyflurane and toluene pharmacokinetics

Gradual or Abrupt Nitrous Oxide Administration in a Canine Model of Critical Coronary Stenosis Induces Regional Myocardial Dysfunction That Is Worsened by Halothane

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