Increase in Alcohol Intake, Reduced Flexibility of Alcohol Drinking, and Evidence of Signs of Alcohol Intoxication in Sardinian Alcohol‐Preferring Rats Exposed to Intermittent Access to 20% Alcohol

Loi, Barbara; Lobina, Carla; Maccioni, Paola; Fantini, Noemi; Carai, Mauro A.M.; Gessa, Gian Luigi; Colombo, Giancarlo

doi:10.1111/j.1530-0277.2010.01311.x

Cited by 55 publications

(48 citation statements)

References 36 publications

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“…We interpret this to indicate that IAA rats may already be at maximum in terms of expression of pathological drinking. Finally, a study in an alcohol-preferring rat strain for less • than 1 month found relative resistance to quinine adulteration in IAA versus CAA in rats, but still some sensitivity to quinine in the former (Loi et al 2010). This fi nding agrees with our study showing some quinine sensitivity at ~1½ months relative to 3-4 months of IAA intake; we used outbred Wistar rats (Hopf et al 2010), which consume alcohol but are not selected to be alcoholpreferring.…”

Section: Aversion Resistance With Intermittent Versus Continuous Accesupporting

confidence: 90%

“…Cocaine intake despite pairing with footshock is considered the most robust model for compulsive addiction (Deroche-Gamonet et al 2004;Vanderschuren and Everitt 2004), but to our knowledge similar experiments have not been reported with alcohol. Instead, a number of studies in rodents, using bitter-tasting quinine to examine aversionresistant alcohol intake, have reported that the animals tolerate in alcohol the same concentrations of quinine that dramatically reduce water intake (Hopf et al 2010;Loi et al 2010;Spanagel et al 1996;Spanagel and Holter 1999;TuryabahikaThyen and Wolffgramm 2006;Vengeliene et al 2009;Wolffgramm and Heyne 1991;Wolffgramm et al 2000).…”

Section: Rodent Models Of Aversion Resistancementioning

confidence: 97%

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Translational Models of Interactions Between Stress and Alcohol Consumption: Strengths and Limitations

Hopf¹,

Sparta²,

Bonci³

2011

ILAR Journal

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Much has been written about the interaction of stressors (physical, social, and psychological) and alcohol addiction based on studies in humans and preclinical models. We begin by considering the significance and complexity of alcoholism and the options for effectively modeling it in animals, particularly rodents. We then focus on the following aspects of stress-alcohol interactions: (1) compulsive alcohol consumption, characterized by continued intake despite the presence of stressful or aversive consequences; (2) the possible relationship between acute stress and increased alcohol intake; (3) an apparent cross sensitization of stress and alcohol exposure, which increases both future reactivity to stress and the risk of developing alcohol addiction; and (4) efforts to target stress in therapeutic interventions for alcoholism. We also describe possible neuroadaptations and genetic factors that may interact with stress to increase susceptibility to alcoholism. Throughout, we describe the challenges and inconsistencies inherent in both human and animal studies of alcoholism, its etiology, and its impacts. We believe the relationship between preclinical and human studies is of paramount importance to understand addiction-related behavior in humans and to direct, improve, and expand animal models. It is our hope that a full understanding of the mechanistic bases of pathological alcohol intake will have translational benefits for the development of behavioral and pharmacological therapies.

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Section: Aversion Resistance With Intermittent Versus Continuous Accesupporting

confidence: 90%

Section: Rodent Models Of Aversion Resistancementioning

confidence: 97%

Translational Models of Interactions Between Stress and Alcohol Consumption: Strengths and Limitations

Hopf¹,

Sparta²,

Bonci³

2011

ILAR Journal

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“…In that study, rats that received intermittent access to alcohol (i.e., every other day) showed a gradual increase in alcohol intake over time. This escalation of alcohol intake over time in intermittent/every-other-day models has been confirmed by recent studies that have reintroduced this approach in the field of alcoholism research (Simms et al, 2008;Loi et al, 2010;Hwa et al, 2011;Melendez, 2011;Gilpin et al, 2012). Likewise, classic studies by Wolffgramm (1991), Wolffgramm andHeyne (1991, 1995) demonstrated that rats increase their levels of alcohol intake after lengthy periods (i.e., months) of relatively stable ethanol intake.…”

Section: Escalation Of Drug Usementioning

confidence: 52%

Compulsive drug use and its neural substrates

Lesscher

Vanderschuren²

2012

Reviews in the Neurosciences

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Drug addiction is a chronic relapsing brain disease, characterized by compulsive drug use. Despite the fact that drug addiction affects millions of people worldwide, treatments for this disorder are limited in number and efficacy. In our opinion, understanding the neural underpinnings of drug addiction would open new avenues for the development of innovative treatments for this disorder. Based on an awareness that drug use and drug reward do not equal drug addiction, there has been increasing interest in developing animal models of addiction that mimick the loss of control over drug use more closely than existing models aimed at studying drug reward. The present review provides an overview of animal studies of compulsive drug use and the neural mechanisms involved. First, the employed models are summarized, with a particular emphasis on models of escalation of drug use and resistance to punishment. Next, we discuss mechanisms within the (ventral and dorsal) striatum and (central) amygdala that have recently been implicated in the compulsive seeking and taking of alcohol and cocaine. The studies discussed here provide a promising line of research that will advance our knowledge of the neural circuits involved in the self-destructive behavior that characterizes drug addiction.

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“…They are reported to achieve pharmacologically relevant BEC at each drinking session and to exhibit "binge"-like drinking behavior (i.e., three drinking bouts per day; Loi et al 2010).…”

Section: Models Of Alcohol Consumptionmentioning

confidence: 99%

Advancing Addiction Treatment: What Can We Learn from Animal Studies?

Wu¹,

Schulz²

2012

ILAR Journal

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Substance addiction is a maladaptive behavior characterized by compulsive and uncontrolled self-administration of a substance (drug). Years of research indicate that addictive behavior is the result of complex interactions between the drug, the user, and the environment in which the drug is used; therefore, addiction cannot simply be attributed to the neurobiological actions of a drug. However, despite the obvious complexity of addictive behavior, animal models have both advanced understanding of addiction and contributed importantly to the development of medications to treat this disease. We briefl y review recent animal models used to study drug addiction and the contribution of data generated by these animal models for the clinical treatment of addictive disorders.

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Increase in Alcohol Intake, Reduced Flexibility of Alcohol Drinking, and Evidence of Signs of Alcohol Intoxication in Sardinian Alcohol‐Preferring Rats Exposed to Intermittent Access to 20% Alcohol

Cited by 55 publications

References 36 publications

Translational Models of Interactions Between Stress and Alcohol Consumption: Strengths and Limitations

Translational Models of Interactions Between Stress and Alcohol Consumption: Strengths and Limitations

Compulsive drug use and its neural substrates

Advancing Addiction Treatment: What Can We Learn from Animal Studies?

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