Incorporation of whole oat, especially bran, into a high-fat diet, improves cardio-metabolic risk factors in type 2 diabetic rats

Bensalah, Farid; Harrat, Nour el Imane; Affane, Fouad; Chekkal, Hadjera; Lamri‐Senhadji, Myriem

doi:10.1108/nfs-05-2018-0150

Cited by 4 publications

(3 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Life style is a major determinant of vitamin D status, and low vitamin D is a health problem, particularly in people of developing countries (Ranasinghe et al, 2018;Syed et al, 2019). Current study revealed the negative effects of HFD-induced obesity against vitamin D status, and therefore, the need for life style modification or diet improvements in preventing the side effects of HFD is further warranted, as previously suggested by Bensalah et al (2018). Previous studies have suggested numerous supplements for improving cardiometabolic risk factors, body weight or oxidative stress markers in animal models (Ani and Aginam, 2018;Mir et al, 2019); however, our study, for the first time, specified the role of vitamin D in improving the inflammatory status in the renal tissue and renal injury in HFDinduced vitamin D deficiency.…”

Section: Discussionsupporting

confidence: 55%

Histological, metabolic, and inflammatory changes in the renal tissues of high-fat diet-induced obese rats after vitamin D supplementation

Avestaei

Yaghchiyan

Alihemmati

et al. 2020

NFS

View full text Add to dashboard Cite

Purpose Obesity is a major risk factor for chronic renal fibrosis and kidneys’ structural and inflammatory impairments. This study aims to examine the possible therapeutic effects of vitamin D supplementation against renal inflammatory and kidney’s structural fibrosis and degeneration. Design/methodology/approach Forty male Wistar rats were divided into two groups for 16 weeks: normal diet (ND) and high-fat diet (HFD); then, each group was subdivided into two groups including ND, ND + vitamin D and HFD, HFD + vitamin D. Vitamin D supplementation was done for five weeks at 500 IU/kg dosage. Renal tissue concentrations of tumor necrosis factor (TNF)-α, interleukin 6, interleukin 1 beta, monocyte chemoattractant protein (MCP)-1 and transforming growth factor-beta (TGF-β), serum values of lipids, markers of glucose homeostasis and urea, creatinine and uric acid and renal tissue histological and structural changes were determined. Findings HFD feeding caused remarkable histological and structural changes including higher TNF-α, MCP-1 and TGF-β concentrations in renal tissues of rats, whereas vitamin D has potent anti-inflammatory effects (P = 0.036, 0.047 and 0.02, respectively). Vitamin D administration also reduced urea and uric acid concentrations (P = 0.023 and 0.049, respectively). Moreover, vitamin D reduced glomerulomegaly, reduced lipid accumulation and limited dilated Bowman’s space in rats and improved glycemic status by increasing insulin (P = 0.04) and reducing insulin resistance (P = 0.006). Research limitations/implications The current study has some limitations. It was better to measure the level of inflammatory cytokines’ expression in the kidney tissues. Additionally, the measurement of baseline values of inflammatory cytokines was not possible because of the possibility of animals’ drop-out. Practical implications According to the study findings, vitamin D treatment in the current report showed a significant therapeutic role in reducing inflammation, improving glycemic and lipid abnormalities and structural and histological modifications in renal tissues of rats. These findings have a great value because after confirming in a human model, vitamin D can be suggested as a potential therapeutic tool in clinical practice. Social implications After being confirmed by other animal or human researches, the results of the current work could have great social implications by reducing the prevalence of obesity-related renal complications and highlighting the beneficial roles of vitamin D. Originality/value To the best of the authors’ knowledge, this is the first study to investigate the histological and inflammatory changes in the kidneys and metabolic parameters in the HFD induced rats and also clarified the therapeutic roles of vitamin D in ameliorating the inflammatory, histological, metabolic and functional changes in the kidneys of obese rats.

show abstract

Section: Discussionsupporting

confidence: 55%

Histological, metabolic, and inflammatory changes in the renal tissues of high-fat diet-induced obese rats after vitamin D supplementation

Avestaei

Yaghchiyan

Alihemmati

et al. 2020

NFS

View full text Add to dashboard Cite

show abstract

“…Evidences have shown that combination of two or more food materials such as cereals and legumes usually increased nutritional properties of the final food products (Tsehayneh et al , 2020). Nutritionally, it is evident that regular intakes of food products that are high in plant bioactive compounds, such as in the present study food formulations, usually prevent diseases such as obesity, diabetes and hypertension (Bensalah et al , 2019; Ardiansyah et al , 2019; Tan et al , 2019).…”

Section: Resultsmentioning

confidence: 72%

Nutritional, biochemical and organoleptic properties of high protein-fibre functional foods developed from plantain, defatted soybean, rice-bran and oat-bran flour

Oluwajuyitan

Ijarotimi

Fagbemi

2020

NFS

View full text Add to dashboard Cite

Purpose This study was aimed to develop and evaluate nutritional efficacy and bio-efficacy of food products from plantain, soycake, rice-bran and oat-bran flour. Design/methodology/approach The flour samples were blended as follows: plantain 70% and soycake 30% (PS); plantain 65%, soycake 30% and rice bran 5% (PSR); plantain 65%, soycake 30% and oat bran 5% (PSO); and plantain 60%, soycake 30%, rice bran 5% and oat bran 5% (PSRO). Antioxidant and nutritional properties of the blended foods and controls (100% plantain and Cerolina) were determined. Findings Protein (16.2–19.4 g/100g) and biological values (98.5–99.3%) of the food samples were significantly (p = 0.03) higher than 100% plantain (5 g/100g, 31.6%) and Cerolina (17.9 g/100g, 98.3%). Pack cell volume (36.2–42%), serum protein (7.3–9.3 mg/dL), urea/creatinine (1.1–2.8) and aspartate-aminotransferase/alanine-aminotransferase ratio (0.9–1) of the foods were significantly (p = 0.03, 0.01, 0.02 and <0.01, respectively) higher than 100% plantain (28%, 1.6 mg/dL, 4.6 and 0.8) and Cerolina (46%, 4.9 mg/dL, 3 and 0.73). In vivo antioxidant activity of the food samples decreased from PSRO to PSO, PSR and PS, respectively and were higher than control samples. Nutritional performance of formulated foods in rats was similar to that of Cerolina, but higher than in 100% plantain. Cerolina and 100% plantain were rated higher in overall acceptability than formulated foods; however, PSO was most preferred followed by PSRO for the formulated foods. Originality/value The study established that PSRO was rated best in terms of nutrition, growth performance and antioxidant activities. Hence, this food may be suitable as functional food to prevent malnutrition and oxidative stress.

show abstract

“…In oat β-glucan is mainly located in bran and aleurone layers (Demirbas,2005). It is relatively inexpensive oat flour milling by-productand can be added to foods on the assumption that this willcontribute to health benefits (Bensalah et al, 2019,Xue et al, 2020.…”

Section: Introductionmentioning

confidence: 99%

The Study of Particle Size Distribution of Micronized Oat Bran Layer

Dziki

Tarasiuk

Łysiak

et al. 2020

Agricultural Engineering

View full text Add to dashboard Cite

AbstractThe aim of this work was to study the particle size distribution of micronized oat bran. An impact classified mill was used to pulverizing. Before the pulverizing raw material was sterilized using overheated steam at 150°C during 3.5 min. The moisture of bran after sterilization decreased from 7.2 to about 3.9%. Five speeds of the rotor disc were used: 2600, 2970, 3340, and 3710 rpm. For each speed of the rotor disc the following speeds of classifier wheel were applied: 480, 965, 1450, 1930, 2410 and 2890 rpm. The particle size distribution of oat bran layer was measured by laser light scattering. Moreover, the sense of touch of coarse particles of micronized oat bran on a tongue was assessed according to five point scale. The largest fragmentation of the oat bran was obtained at a disc speed of 3710 rpm and at a classifier rotation speed of 1930 rpm, whereas the most coarse particles were obtained when these parameters were 3340 rpm and 480 rpm, respectively. On the other hand, the highest uniformity in size of particles in size was observed when the lowest speed of disc and classifier were used. Moreover, for the most samples the pulverized particles of oat bran were almost not discernible on tongue.

show abstract

Incorporation of whole oat, especially bran, into a high-fat diet, improves cardio-metabolic risk factors in type 2 diabetic rats

Cited by 4 publications

References 50 publications

Histological, metabolic, and inflammatory changes in the renal tissues of high-fat diet-induced obese rats after vitamin D supplementation

Histological, metabolic, and inflammatory changes in the renal tissues of high-fat diet-induced obese rats after vitamin D supplementation

Nutritional, biochemical and organoleptic properties of high protein-fibre functional foods developed from plantain, defatted soybean, rice-bran and oat-bran flour

The Study of Particle Size Distribution of Micronized Oat Bran Layer

Contact Info

Product

Resources

About