Incorporation of metal‐organic framework amino‐modified MIL‐101 into glycidyl methacrylate monoliths for nano LC separation

Abstract

Metal‐organic frameworks consisting of amino‐modified MIL‐101(M: Cr, Al, and Fe) crystals have been synthesized and subsequently incorporated to glycidyl methacrylate monoliths to develop novel stationary phases for nano‐liquid chromatography. Two incorporation approaches of these materials in monoliths were explored. The metal‐organic framework materials were firstly attached to the pore surface through reaction of epoxy groups present in the parent glycidyl methacrylate‐based monolith. Alternatively, NH2‐MIL‐101(M) were admixed in the polymerization mixture. Using short time UV‐initiated polymerization, monolithic beds with homogenously dispersed metal‐organic frameworks were obtained. The chromatographic performance of embedded UV‐initiated composites was demonstrated with separations of polycyclic aromatic hydrocarbons and non‐steroidal anti‐inflammatory drugs as test solutes. In particular, the incorporation of the NH2‐MIL‐101(Al) into the organic polymer monoliths led to an increase in the retention of all the analytes compared to the parent monolith. The hybrid monolithic columns also exhibited satisfactory run‐to‐run and column‐to‐column reproducibility.

Development of hybrid monoliths incorporating metal–organic frameworks for stir bar sorptive extraction coupled with liquid chromatography for determination of estrogen endocrine disruptors in water and human urine samples

“…NH 2 -MIL-101(Al) was prepared according to procedure developed elsewhere by Martínez-Pérez-Cejuela et al [ 34 ]. In short, aluminum chloride (482 mg), 2-aminoterephtalic acid (543.45 mg), and DMF (40 mL) were dissolved together in ultrasonic bath.…”

“…Next, the synthesized MOF was washed with ethanol and dried in oven at 60 °C. Other MOF materials (NH 2 -MIL-101(Cr) and NH 2 -MIL-101(Fe)) were also prepared following the procedure previously reported by Martínez-Pérez-Cejuela et al [ 34 ].…”

Metal-Organic Frameworks in Green Analytical Chemistry

“…Table 3 includes a summary of representative analytical applications of MOFs when included as stationary of pseudo-stationary phases in different chromatographic techniques in the last three years [101][102][103][104][105][106][107][108][109][110][111][112][113][114][115]. Mostly, MOFs form part of composites with silica or polymers in such phases [101,102], hardly being utilized in its neat appearance. It is important to highlight the number of applications with chiral MOFs (prepared incorporating chiral organic ligands) [108][109][110][111].…”

Nano‐liquid chromatography with a new nano‐structured monolithic nanocolumn for proteomics analysis

“…The development of new type of nanocolumns is a critical issue for a wide range of cutting-edge research areas. Although various nanocolumn types such as packed, pillar array columns are still the most popular choice, the monolithic nano-columns provides an enormous versatility, and can be used for a number of challenging applications [11][12][13][14][15][16][17]. These type of columns are promising materials that shows several advantages such as large surface area and easy preparation, especially in narrow internal diameter format.…”