Incorporation of eicosapentaenioic and docosahexaenoic acids into breast adipose tissue of women at high risk of breast cancer: A randomized clinical trial of dietary fish and n‐3 fatty acid capsules

Straka, Shana R.; Lester, Joanne; Cole, Rachel M.; Andridge, Rebecca; Puchala, Sarah; Rose, Angela M.; Clinton, Steven K.; Belury, Martha A.; Yee, Lisa D.

doi:10.1002/mnfr.201500161

Cited by 27 publications

(18 citation statements)

References 39 publications

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“…The same conclusion was reached by a meta-analysis of data from 21 independent prospective cohort studies [3]. Moreover, the association of n-3 LC-PUFAs and the incidence of several cancer types have been highlighted by numerous epidemiological studies [4][5][6][7][8]. In addition to that, n-3 LC-PUFAs intake is associated with positive effects on cardiovascular health [9][10][11], brain function [12,13], immunity [14], and inflammation [15].…”

Section: Introductionmentioning

confidence: 58%

Effects of Bioactive Marine-Derived Liposomes on Two Human Breast Cancer Cell Lines

Elkhoury

Barbieux

et al. 2020

Marine Drugs

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Breast cancer is the leading cause of death from cancer among women. Higher consumption of dietary marine n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) is associated with a lower risk of breast cancer. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are two n-3 LC-PUFAs found in fish and exert anticancer effects. In this study, natural marine-derived lecithin that is rich in various polyunsaturated fatty acids (PUFAs) was extracted from salmon heads and transformed into nanoliposomes. These nanoliposomes were characterized and cultured with two breast cancer lines (MCF-7 and MDA-MB-231). The nanoliposomes decreased the proliferation and the stiffness of both cancer cell types. These results suggest that marine-derived lecithin possesses anticancer properties, which may have an impact on developing new liposomal delivery strategies for breast cancer treatment.

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Section: Introductionmentioning

confidence: 58%

Effects of Bioactive Marine-Derived Liposomes on Two Human Breast Cancer Cell Lines

Elkhoury

Barbieux

et al. 2020

Marine Drugs

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“…Evidence from meta-analyses of Yang et al [53] and Nindrea et al [54] clearly confirms that higher intake ratio of n-3/n-6 PUFAs is associated with lower risk of breast cancer among females, which implies breast cancer prevention and treatment might be possible through increasing dietary intake ratio of n-3/n-6 PUFA. Additionally, Straka et al [55] and Maillard et al [56] observed increased accumulation of C20:5, c,c,c,c,c-∆5,8,11,14,17 and C22:6, c,c,c,c,c,c-∆4,7,10,13,16,19 in breast adipose tissue of women at high risk of breast cancer; the accumulation resulted from both diet supplementation and increased fish consumption. These results are in line with numerous studies demonstrating anticarcinogenic properties of long chain PUFA [36,57,58].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Diet Supplementation with Pomegranate and Bitter Melon on Lipidomic Profile of Serum and Cancerous Tissues of Rats with Mammary Tumours

et al. 2020

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The aim of this study was to present overall lipid profile of organisms with ongoing neoplastic process and applied diet supplementation with pomegranate seed oil (PSO) and bitter melon extract (BME). The following were quantified in serum and cancerous tissues of rats suffering from mammary tumours: fatty acids, conjugated fatty acids and sterols, their oxidised metabolites (malondialdehyde and oxysterols) and lipoxygenase (LOX) metabolites of polyunsaturated fatty acids. The obtained results indicate that abnormalities in lipid metabolism accompany neoplastic process. These differences concern all classes of lipids and most pathways of their transformation, with the special emphasis on lipid peroxidation and LOX-mediated metabolism. Cancer process appears to be so detrimental that it may conceal positive influence of dietary modifications. The lack of anticarcinogenic properties of PSO and BME in this model may be due to their antioxidant properties or elevated levels of conjugated linoleic acids (CLA), which change CLA isomer activity from anti- to pro-tumorigenic. As CLA are the product of conjugated linolenic acids (CLnA) endogenous metabolism, high CLA levels may be explained by applied diet enrichment.

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“…Associations have also been found between the fatty acid composition of erythrocyte membranes and the risk of colon cancer, colon adenomas, breast cancer and non-Hodgkin's lymphoma. 18,33,[36][37][38] Some studies have highlighted changes in the fatty acid composition of the erythrocyte membranes of cirrhotic patients. 24,30,39,40 For example, Guarini et al 24 .…”

Section: Discussionmentioning

confidence: 99%

Fatty acid composition of the erythrocyte membrane and risk of hepatocellular carcinoma in cirrhotic patients

Mouillot¹,

Rizk²,

Barros³

et al. 2020

Aliment Pharmacol Ther

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Background: Disturbances in fatty acid (FA) metabolism have been reported in cirrhosis, but the role of FAs in the development of hepatocellular carcinoma (HCC) is still unclear. Biomarkers are a promising means to explore the associations between exogenous intake or endogenous production of FAs and cancer risk. Aim: To estimate the relationship between fatty acid content in erythrocyte membranes and HCC risk in cirrhotic patients Methods: The "CiRCE" case-control study recruited cirrhotic patients from six French hospitals between 2008 and 2012. Cases were cirrhotic patients with HCC (n = 349); controls were cirrhotic patients without HCC at inclusion (n = 550). FA composition of phospholipids in erythrocyte membranes was determined by high performance gas chromatography. Odds ratios for HCC risk according to FA concentrations were estimated with multivariable logistic regression. Results: HCC patients were older and more often men (P < 0.001). In both groups, saturated FAs represented more than 39% of all FAs in erythrocyte membranes, mono-unsaturated FAs around 14%, and polyunsaturated FAs around 46%. High levels of C15:0 + C17:0, C20:1 n-9, C18:2 n-6 and C20:2 n-6 were associated with higher risk of HCC. The levels of C18:0 and C20:4 n-6 were lower in HCC cases than in controls. Conclusions: The FA composition of erythrocyte membranes differed according to the presence of HCC with higher levels of saturated FAs, linoleic and eicosadienoic acids, and lower levels of stearic and arachidonic acids. These alterations may reflect particular dietary patterns and/or altered FA metabolism. Further investigations are warranted.

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Incorporation of eicosapentaenioic and docosahexaenoic acids into breast adipose tissue of women at high risk of breast cancer: A randomized clinical trial of dietary fish and n‐3 fatty acid capsules

Abstract: Fish provides an excellent source of n-3 PUFAs that increases breast adipose EPA, DHA similar to supplements and represents a well-tolerated intervention for future studies of the impact of n-3 PUFAs and dietary patterns on breast cancer.

Cited by 27 publications

References 39 publications

Effects of Bioactive Marine-Derived Liposomes on Two Human Breast Cancer Cell Lines

Effects of Bioactive Marine-Derived Liposomes on Two Human Breast Cancer Cell Lines

The Effect of Diet Supplementation with Pomegranate and Bitter Melon on Lipidomic Profile of Serum and Cancerous Tissues of Rats with Mammary Tumours

Fatty acid composition of the erythrocyte membrane and risk of hepatocellular carcinoma in cirrhotic patients

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