Incorporation of carbonate and magnesium ions into synthetic hydroxyapatite: The effect on physicochemical properties

Kolmas, Joanna; Jaklewicz, Andrzej; Zima, Aneta; Bućko, Mirosław M.; Paszkiewicz, Z.; Lis, Jerzy; Ślósarczyk, A.; Kołodziejski, Wacław

doi:10.1016/j.molstruc.2010.11.058

Cited by 89 publications

(94 citation statements)

References 49 publications

(78 reference statements)

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“…Concerning 1 H NMR characterizations of the already complex systems of mesoporous silica coexisting with its heterogeneous surface layer of calcium phosphates, these NMR peaks are a nuisance and may lead to assignment ambiguities—even as to the precise organic source molecules, as shown below. However, these NMR signals are worth discussing in more depth because similar (but distinct) NMR responses are frequently observed across the shift range 0.8–1.4 ppm from apatites, encompassing HA, 13−16,22 HCA, 6,13,14,19−21 fluoro-hydroxyapatite, 15,87 as well as bone mineral. 6,13,14 These resonances are usually very weak from well-crystalline HA, as may be verified from the 1 H NMR spectra of Figure 6(a, b).…”

Section: Discussionmentioning

confidence: 99%

Proton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO–SiO₂–P₂O₅ Glasses in Vitro: Insights from Solid-State NMR

et al. 2017

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When exposed to body fluids, mesoporous bioactive glasses (MBGs) of the CaO–SiO2–P2O5 system develop a bone-bonding surface layer that initially consists of amorphous calcium phosphate (ACP), which transforms into hydroxy-carbonate apatite (HCA) with a very similar composition as bone/dentin mineral. Information from various 1H-based solid-state nuclear magnetic resonance (NMR) experiments was combined to elucidate the evolution of the proton speciations both at the MBG surface and within each ACP/HCA constituent of the biomimetic phosphate layer formed when each of three MBGs with distinct Ca, Si, and P contents was immersed in a simulated body fluid (SBF) for variable periods between 15 min and 30 days. Directly excited magic-angle-spinning (MAS) 1H NMR spectra mainly reflect the MBG component, whose surface is rich in water and silanol (SiOH) moieties. Double-quantum–single-quantum correlation 1H NMR experimentation at fast MAS revealed their interatomic proximities. The comparatively minor H species of each ACP and HCA component were probed selectively by heteronuclear 1H–31P NMR experimentation. The initially prevailing ACP phase comprises H2O and “nonapatitic” HPO42–/PO43– groups, whereas for prolonged MBG soaking over days, a well-progressed ACP → HCA transformation was evidenced by a dominating O1H resonance from HCA. We show that 1H-detected 1H → 31P cross-polarization NMR is markedly more sensitive than utilizing powder X-ray diffraction or 31P NMR for detecting the onset of HCA formation, notably so for P-bearing (M)BGs. In relation to the long-standing controversy as to whether bone mineral comprises ACP and/or forms via an ACP precursor, we discuss a recently accepted structural core–shell picture of both synthetic and biological HCA, highlighting the close relationship between the disordered surface layer and ACP.

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Section: Discussionmentioning

confidence: 99%

Proton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO–SiO₂–P₂O₅ Glasses in Vitro: Insights from Solid-State NMR

et al. 2017

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“…These specific two bands are almost absent for the PCL/nBG coating after 7 d immersion, indicating even stronger degradation of the composite coating. The main vibrations of PO4 3-bands in the FTIR spectra are detected at 1039 cm -1 , 601 cm -1 , 563 cm -1 , and 1011 cm -1[69][70][71][72], as presented in PCL/nBG coating and pure magnesium, separately. In addition, the presence of a small absorption band at 871 (870) cm -1 can be assigned to the HPO 4 2-ion in the HA structure[73].…”

mentioning

confidence: 96%

In vitro study of polycaprolactone/bioactive glass composite coatings on corrosion and bioactivity of pure Mg

Yang

Michalczyk

Singer

et al. 2015

Applied Surface Science

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“…Bone’s apatite is not a pure HAP; it is naturally doped with different elements and concentrations3. Synthesized HAP is distinguished by its good biocompatibility, osteoconductivity and bone-attachment ability but its brittleness, rigidity and high degradation rate have limited HAP from being used in the broad spectrum of biomedical applications4567.…”

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confidence: 99%

Physico-mechanical and morphological features of zirconia substituted hydroxyapatite nano crystals

Mansour

El-Dek

Ahmed

2017

Sci Rep

138

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Zirconia doped Hydroxyapatite (HAP) nanocrystals [Ca10(PO4)6−x(ZrO2)x(OH)2]; (0 ≤ x ≤ 1 step 0.2) were synthesized using simple low cost facile method. The crystalline phases were examined by X-ray diffraction (XRD). The crystallinity percentage decreased with increasing zirconia content for the as-synthesized samples. The existence of zirconia as secondary phase on the grain boundaries; as observed from scanning electron micrographs (FESEM); resulted in negative values of microstrain. The crystallite size was computed and the results showed that it increased with increasing annealing temperature. Thermo-gravimetric analysis (TGA) assured the thermal stability of the nano crystals over the temperature from room up to 1200 °C depending on the zirconia content. The corrosion rate was found to decrease around 25 times with increasing zirconia content from x = 0.0 to 1.0. Microhardness displayed both compositional and temperature dependence. For the sample (x = 0.6), annealed at 1200 °C, the former increased up to 1.2 times its original value (x = 0.0).

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Incorporation of carbonate and magnesium ions into synthetic hydroxyapatite: The effect on physicochemical properties

Cited by 89 publications

References 49 publications

Proton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO–SiO₂–P₂O₅ Glasses in Vitro: Insights from Solid-State NMR

Proton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO–SiO₂–P₂O₅ Glasses in Vitro: Insights from Solid-State NMR

In vitro study of polycaprolactone/bioactive glass composite coatings on corrosion and bioactivity of pure Mg

Physico-mechanical and morphological features of zirconia substituted hydroxyapatite nano crystals

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Incorporation of carbonate and magnesium ions into synthetic hydroxyapatite: The effect on physicochemical properties

Cited by 89 publications

References 49 publications

Proton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO–SiO2–P2O5 Glasses in Vitro: Insights from Solid-State NMR

Proton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO–SiO2–P2O5 Glasses in Vitro: Insights from Solid-State NMR

In vitro study of polycaprolactone/bioactive glass composite coatings on corrosion and bioactivity of pure Mg

Physico-mechanical and morphological features of zirconia substituted hydroxyapatite nano crystals

Contact Info

Product

Resources

About

Proton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO–SiO₂–P₂O₅ Glasses in Vitro: Insights from Solid-State NMR

Proton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO–SiO₂–P₂O₅ Glasses in Vitro: Insights from Solid-State NMR