2015
DOI: 10.1016/j.actbio.2015.07.023
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Incorporation of aligned PCL–PEG nanofibers into porous chitosan scaffolds improved the orientation of collagen fibers in regenerated periodontium

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Cited by 107 publications
(95 citation statements)
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References 60 publications
(60 reference statements)
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“…Among them are natural and synthetic polymers, glasses, ceramics and hydrogels . Furthermore, a great many methods have been proposed to improve these materials, for example by altering their structural properties or by preloading them with growth or differentiation factors . As stated above, the choice of material depends on the specific tissue‐engineering goal.…”
Section: Leads For Tissue Engineering Of the Pdlmentioning
confidence: 99%
“…Among them are natural and synthetic polymers, glasses, ceramics and hydrogels . Furthermore, a great many methods have been proposed to improve these materials, for example by altering their structural properties or by preloading them with growth or differentiation factors . As stated above, the choice of material depends on the specific tissue‐engineering goal.…”
Section: Leads For Tissue Engineering Of the Pdlmentioning
confidence: 99%
“…Jiang et al reported increased PDL-like tissue formation with mature collagen fibers using aligned PCL-polyethylene glycol (PEG) nanofibers embedded into porous chitosan scaffolds and seeded with bone marrow mesenchymal stem cells. [21] Similar findings have been observed in applications for neural and cardiac tissue regeneration: Koepsell et al noted increased cellular orientation of intervertebral disc-derived cells on increasingly aligned electrospun PCL fibers resulted in higher ECM production, including collagen and glycosaminoglycans, [22] while Ifkovits et al found enhanced collagen alignment on oriented poly(glycerol sebacate) fibers when seeded with cardiocytes and implanted subcutaneously. [23] However, it remains difficult to create three-dimensional scaffolds using these techniques without the presence of a more complex and customizable system such as a 3-D printer that could position fibers in directions relevant to the anatomical structure of tissue we attempt to model, thereby recapitulating its unique geometric complexity.…”
Section: Discussionmentioning
confidence: 56%
“…Moreover, 19.7% of the studies evaluated CS in the regeneration of skin [24, 27, 29, 6371], 14.7% in nervous tissue [30, 72–79], 11.5% in cartilage [32, 8184, 87, 88], and 3.3% in periodontal [33, 90] structures. The remaining studies involved regeneration of colorectal [26], mammary [89], tympanic membrane [31], and vascular [34] tissues (1.6% each).…”
Section: Resultsmentioning
confidence: 99%