Incorporation of Adenosine and Adenosine Triphosphate into Rat Myocardium

Hattori, Eizou; Miyazaki, Tadashi; Nakamura, Motoomi

doi:10.1536/ihj.10.47

Cited by 14 publications

(2 citation statements)

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“…The latter effect is somewhat surprising since ATP, unlike adenosine, does not readily cross cell membranes (Lowy, Davoll & Brown, 1952;Hoffman & Okita, 1965;Hattori, Miyazaki & Nakamura, 1969). A possible explanation is that the spasmolytic effect of ATP depends on its first being hydrolysed to adenosine at the cell surface, a reaction which is known to occur rapidly in the heart (Baer & Drummond, 1968) and in the gut (Burnstock, 1972) and may, therefore, also occur in the trachea.…”

Section: Discussionmentioning

confidence: 99%

Effects of Some Purine Derivatives on the Guinea‐pig Trachea and Their Interaction With Drugs That Block Adenosine Uptake

Coleman¹

1976

British J Pharmacology

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I Adenosine, adenosine 5'-triphosphate (ATP), adenine, inosine and guanosine all caused concentration-dependent relaxations of guinea-pig tracheal smooth muscle in vitro. The relative potencies in descending order were: adenine > guanosine > inosine > adenosine > ATP 2 Responses to the purine compounds were unaffected by propranolol (1 jg/ml). 3 The spasmolytic potencies of adenosine and ATP were greatly enhanced in the presence of the adenosine uptake blocking drugs dipyridamole, hexobendine or Dilazep, whereas responses to adenine were unaffected and those to inosine and guanosine were reduced. 4 The spasmolytic potencies of noradrenaline, aminophylline, prostaglandin E2 and glyceryl trinitrate were unaffected by dipyridamole, hexobendine and Dilazep. 5 It is suggested that an adenosine uptake process may exist in the trachea of the guinea-pig and that this process is inhibited by dipyridamole, hexobendine and Dilazep.

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Section: Discussionmentioning

confidence: 99%

Effects of Some Purine Derivatives on the Guinea‐pig Trachea and Their Interaction With Drugs That Block Adenosine Uptake

Coleman¹

1976

British J Pharmacology

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“…The blockade by theophylline of the responses to ATP, adenosine and arterial occlusion wore off almost completely within 30 min. It has generally been accepted that a high energy phosphate compound such as ATP, unlike adenosine, does not readily cross normal cell membranes (22)(23)(24). Recently, For rester and Williams (25), however, evidenced the release of ATP from rat isolated heart cells under hypoxia.…”

Section: Effects Of Atp Adp Amp Imp Adenosine Amt Inos•ine On Thementioning

confidence: 99%

A Possible Purinergic Mechanism for Reactive Ischemia in Isolated, Cross-Circulated Rat Kidney

Sakai¹,

Akima²,

Nabata³

1979

Japanese Journal of Pharmacology

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Abstract-The isolated kidney of the recipient rat was perfused at a fixed flow rate with blood from a donor by a cross-circulation technique. The renal vasculature responded to the release of arterial occlusion with vasoconstriction, the magnitude of which was increased with increase in the duration of occlusion. ATP, ADP, AMP, adenosine. noradrenaline and 5-HT injected into the renal artery induced a prominent vasoconstriction; IMP and inosine had only a weak vasoconstrictor effect even in large doses. Theophylline reduced the vasoconstriction in response to arterial occlusion and to ATP and adenosine but did not affect that produced by noradrenaline or 5-HT. This suggests that adenine compounds, particularly adenosine, may play a role in the genesis of reactive vasoconstriction after arterial occlusion in the isolated rat kidney.Research on the postocclusive vascular response in the kidney was initiated at the end of the 19th century (1), but the response remains the subject of intensive investigation even at present (2-7).Postocclusive vasoconstriction appears to be a characteristic response of the kidney; it is not observed in other tissues (8-9). It has been suggested that mediator substances such as adenosine (5, 7, 10) or adenosine monophosphate (11) may play a role in the genesis of the vasoconstriction.In the rat isolated, cross-circulated kidney, we attempted to elucidate a possible mecha nism responsible for induction of the postocclusive vasoconstriction. MATERIALS AND METHODSMale Sprague-Dawley rats were allowed free access to food and water overnight before use in the present studies. Surgical procedursDonor rats (550-750 g) were anesthetized with pentobarbital sodium (65 mg/kg i.p.).The right jugular vein and carotid artery were exposed and cannulated by polyethylene cannulae. Heparin sodium (1000 U/kg) was injected and the blood pressure was measured from the left femoral artery with a pressure transducer (Nihon Kohden, MPU-0.5). The carotid and jugular cannulae of the donor rat were connected to the perfusion circuit after the circuit had been filled with 15 ml of blood freshly drawn from heparinized rats.Recipient rats (180-250 g) were anesthetized with pentobarbital sodium (75 mg/kg i.p.). According to the method described by , the right kidney, the right renal artery, the superior mesenteric artery, the abdominal part of the inferior vena cava and the abdominal aorta were exposed through an abdominal incision in the mid-line.

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The effects of an intracoronary infusion of adenosine on cardiac performance, blood supply and on myocardial metabolism in dogs

Raberger

Kraupp

et al. 1970

Pflugers Arch.

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Incorporation of Adenosine and Adenosine Triphosphate into Rat Myocardium

Cited by 14 publications

References 0 publications

Effects of Some Purine Derivatives on the Guinea‐pig Trachea and Their Interaction With Drugs That Block Adenosine Uptake

Effects of Some Purine Derivatives on the Guinea‐pig Trachea and Their Interaction With Drugs That Block Adenosine Uptake

A Possible Purinergic Mechanism for Reactive Ischemia in Isolated, Cross-Circulated Rat Kidney

The effects of an intracoronary infusion of adenosine on cardiac performance, blood supply and on myocardial metabolism in dogs

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