Incorporation of 5‐bromodeoxyuridine and 5‐iododeoxyuridine Into Viral Dna and Its Effect on the Infective Process*

Kaplan, Albert S.; Ben-Porat, Tamar; Kamiya, Tomoya

doi:10.1111/j.1749-6632.1965.tb12556.x

Cited by 32 publications

References 24 publications

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Neonatal Herpetic Infection

Tuffli¹

1969

Am J Dis Child

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ALTHOUGH the prognosis in herpes simplex encephalitis remains unclear in view of problems inherent in providing laboratory confirmation of diagnoses,1 reports in current literature 2-8 indicate the disease is severe, often fatal, frequently leaving survivors with neurological sequelae. Until recently, treatment consisted largely of supportive care, with occasional administration of \g=g\-globulin or hyperimmune plasma. During the past three years, several authors described beneficial results in herpes simplex encephalitis with systemic use of idoxuridine (5-iodo-2\m='\-deoxyuridine) .8-13 However, no one has reported experience with systemic use of idoxuridine in the premature infant. Partridge and Millis 14 used intravenously administered idoxuridine in a combined, five-day course of intermittent and continuous infusion in a newborn term infant with systemic herpes simplex. The infant received a total dose of 580 mg/kg and showed clinical improvement, with no toxicity noted. The infant died

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Neonatal Herpetic Infection

Tuffli¹

1969

Am J Dis Child

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Developmental defects in rats treated postnatally with 5‐lododeoxyuridine (IUDR)

Percy¹,

Albert²

1974

Teratology

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Sprague-Dawley rats were treated sc with 100-400 mg/kg/day 5-iododeoxyuridine (IUDR) for 5 days beginning at 1, 5, or 10 days of age. Hair and somatic growth were markedly reduced in rats given 400 mk/kg beginning at 1 day of age. Animals were examined histologically at 10 or 20 days of age. Cerebellar cortical lesions were evident after the highest dosage in animals killed at 10 days of age, but lesions were of lesser magnitude in all series killed at 20 days of age. Retinal dysplasia was observed in rats treated beginning at 1 day of age. Lesions were characterized by thinning of the retina, undulations, and rosette formation in outer retinal layers. Foci of renal dysplasia were evident in rats treated beginning at 1 day of age. Poorly differentiated glomeruli and tubules together with nests of primordial epithelial cells, indicative of impaired nephrogenesis, were located in the superficial cortex. It is known that developmental defects can occur in the cerebellum, retina, and kidney of animals infected perinatally with certain cytolytic viruses. However, these appear to be the first studies demonstrating that a halogenated uridine given to newborn animals may result in obvious renal cortical and retinal dysplasia.

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