Incorporating the Gut Microbiome in the Risk Assessment of Xenobiotics and Identifying Beneficial Components for One Health

Abstract

Three areas of relevance to the gut microbiome in the context of One Health were explored; the incorporation of the microbiome in food safety risk assessment of xenobiotics; the identification and application of beneficial microbial components to various areas under One Health, and; specifically, in the context of antimicrobial resistance. Although challenging, focusing on the microbiota resilience, function and active components is critical for advancing the incorporation of microbiome data in the risk assessment of xenobiotics. Moreover, the human microbiota may be a promising source of beneficial components, with the potential to metabolize xenobiotics. These may have possible applications in several areas, e.g., in animals or plants for detoxification or in the environment for biodegradation. This approach would be of particular interest for antimicrobials, with the potential to ameliorate antimicrobial resistance development. Finally, the concept of resistance to xenobiotics in the context of the gut microbiome may deserve further investigation.

Microbiota analysis for risk assessment of xenobiotics: cumulative xenobiotic exposure and impact on human gut microbiota under One Health approach

“…Since the term OH defines the holistic approach for simultaneously improving human, animal and environmental health through transdisciplinary cooperation (Bronzwaer et al., 2021 ; Buschhardt et al., 2021 ; Ampatzoglou et al., 2022 ), the human gut microbiome needs to also be included as an essential element of the NGRA approach as suggested in Figure 1 (Ortiz et al., 2022 ).…”

Exploring Next Generation Probiotics for Metabolic and Microbiota Dysbiosis Linked to Xenobiotic Exposure: Holistic Approach

“…Recent investigations revealed that microbiota might play an important role in xenobiotic metabolism [ 76 ]. Because of these microbiome-xenobiotic interactions, the human gut microbiota may also be a potential source of probiotics for animals and plants, and environmental bioremediation [ 77 ]. Eventually, future research will need to overcome the additional hurdle of addressing multiple biological, chemical, and physical hazards affecting multiple target organisms through multidisciplinary and holistic approaches [ 78 ].…”

OBEMIRISK‐Knowledge platform for assessing the risk of bisphenols on gut microbiota and its role in obesogenic phenotype: looking for biomarkers

“…Global policies necessitate going beyond the classical risk assessment for guarantying the human health through actions and implementation of the One Health approach. In this context, a new perspective is proposed for the integration of microbiome biomarkers and next generation probiotics potentially impacting and modulating not only human health, but plant, animal health and environment (Ampatzoglou et al, 2022;Ortiz et al, 2022). In this sense, the new terms established for this consortium, such as Endobolome could be proposed as part of the one health glossary that support communication and information exchange between the human health, animal health and food safety sectors (Aguilera et al, 2020).…”