Incorporating protein precipitation to resolve hybrid IP-LC-MS assay interference for ultrasensitive quantification of intact therapeutic insulin dimer in human plasma

Sun, Li; Xu, Yang; Dube, Neal; Anderson, Melanie; Breidinger, Sheila; Vaddady, Pavan; Thornton, Bob; Morrow, Linda; Matthews, Randolph P.; Stoch, S. Aubrey; Woolf, Eric

doi:10.1016/j.jpba.2022.114639

Cited by 1 publication

(2 citation statements)

References 30 publications

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“…employed a STARlet robotic liquid handler (Hamilton, USA) for the analysis of infliximab in serum [77] and Sun et al. used this same model of robotic platform [78] to incorporate protein precipitation and immunoprecipitation for analysis of intact therapeutic insulin dimer in plasma. With a different model, Li et al.…”

Section: Modern Automated Microextraction Methods Of Biological Samplesmentioning

confidence: 99%

“…Although the high-throughput automated sample preparation, before injection in the LC system, the LPME extract was further online enriched with a perfusion column. Van der Gugten et al employed a STARlet robotic liquid handler (Hamilton, USA) for the analysis of infliximab in serum [77] and Sun et al used this same model of robotic platform [78] to incorporate protein precipitation and immunoprecipitation for analysis of intact therapeutic insulin dimer in plasma. With a different model, Li et al employed a TOMTEC Quadra 4 liquid handling workstation and a Waters Ostro protein precipitation 96-well plate for analysis of quetiapine in plasma [79].…”

Section: Modern Automated Lpme Of Biological Samplesmentioning

confidence: 99%

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Modern automated microextraction procedures for bioanalytical, environmental, and food analyses

Sartore

Medina

Bocelli

et al. 2023

J of Separation Science

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Sample preparation frequently is considered the most critical stage of the analytical workflow. It affects the analytical throughput and costs; moreover, it is the primary source of error and possible sample contamination. To increase efficiency, productivity, and reliability, while minimizing costs and environmental impacts, miniaturization and automation of sample preparation are necessary. Nowadays, several types of liquid‐phase and solid‐phase microextractions are available, as well as different automatization strategies. Thus, this review summarizes recent developments in automated microextractions coupled with liquid chromatography, from 2016 to 2022. Therefore, outstanding technologies and their main outcomes, as well as miniaturization and automation of sample preparation, are critically analyzed. Focus is given to main microextraction automation strategies, such as flow techniques, robotic systems, and column‐switching approaches, reviewing their applications to the determination of small organic molecules in biological, environmental, and food/beverage samples.

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Section: Modern Automated Microextraction Methods Of Biological Samplesmentioning

confidence: 99%

Section: Modern Automated Lpme Of Biological Samplesmentioning

confidence: 99%

Modern automated microextraction procedures for bioanalytical, environmental, and food analyses

Sartore

Medina

Bocelli

et al. 2023

J of Separation Science

View full text Add to dashboard Cite

show abstract

Incorporating protein precipitation to resolve hybrid IP-LC-MS assay interference for ultrasensitive quantification of intact therapeutic insulin dimer in human plasma

Cited by 1 publication

References 30 publications

Modern automated microextraction procedures for bioanalytical, environmental, and food analyses

Modern automated microextraction procedures for bioanalytical, environmental, and food analyses

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