Incorporating N-acetylcysteine and tricalcium phosphate into epoxy resin-based sealer improved its biocompatibility and adhesiveness to radicular dentine

Camargo, Carlos Henrique; Gomes, Laís Carolina Landim; França, Monique Costa Moreira; Bittencourt, Tatiane Sampaio; Valera, Márcia Carneiro; Camargo, Samira Esteves Afonso; Bottino, Marco C.

doi:10.1016/j.dental.2019.09.001

Cited by 13 publications

(16 citation statements)

References 23 publications

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“…However, future studies are still needed to improve bonding strength to guarantee acceptable behavior in clinical practice. In contrast to a recent study in which increased adhesion of sealer was observed after adding NAC, 21 the current study showed that incorporating NAC decreased the bonding strength. This difference could be attributed to two factors.…”

Section: Discussioncontrasting

confidence: 99%

The effect of N-acetylcysteine on the antibacterial capability and biocompatibility of nano silver–containing orthodontic cement

Ding¹,

Qian²,

Chen³

et al. 2021

The Angle Orthodontist

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Objectives To determine whether the incorporation of N-acetylcysteine (NAC) improves the antibacterial ability and biocompatibility of nano silver (NAg)–containing orthodontic cement. Materials and Methods NAg was synthesized using a sodium citrate reduction method. NAg particles were characterized using transmission electron microscopy and ultraviolet-visible absorption spectra. NAg and NAC were incorporated into a resin-modified glass ionomer cement. Enamel shear bond strength (SBS), antibacterial capability, and cytotoxicity were evaluated. Results Incorporating 0.15% NAg and 20% NAC had no adverse effect on the SBS of orthodontic cement (P > .1). Adding NAC into NAg-containing cement greatly reduced the biofilm metabolic activity and lactic acid production (P < .05) and lowered the colony unit–forming counts by approximately 1 log (P < .05). The cell viability against NAg-containing cement was improved by NAC (P < .05). Conclusions The incorporation of NAC into NAg-containing cement achieved stronger antibacterial capability and better biocompatibility, without compromising the enamel SBS. The combined use of NAC and NAg is promising to combat caries in orthodontic practice.

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Section: Discussioncontrasting

confidence: 99%

The effect of N-acetylcysteine on the antibacterial capability and biocompatibility of nano silver–containing orthodontic cement

Ding¹,

Qian²,

Chen³

et al. 2021

The Angle Orthodontist

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“…TCP and HA have been applied in several dental and maxillofacial procedures, including endodontic treatments [7,8]. The calcium ions released by TCP and its biocompatibility can aid in the stimulation of odontoblasts, thus promoting the formation of reparative dentin.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars

Guerrero‐Gironés

Alcaina-Lorente

Ortiz-Ruiz

et al. 2021

IJERPH

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Bioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and collagen (C) scaffold with mineral trioxide aggregate (MTA) on the vital pulp of rat molars. Thirty-two molars of Sprague–Dawley rats underwent direct pulp capping with β-TCP/HA/C (n = 16) and MTA (n = 16). After 30 days, the following parameters were evaluated in the tested samples: the degree of pulp inflammation and pulp vitality, the presence of reparative dentin, the homogeneity of the odontoblastic layer, and the presence of pulp fibrosis. No statistically significant differences were observed between HA/β-TCP/C and MTA in terms of the degree of inflammation (p = 0.124). Significant differences were found in reparative dentin formation between the treatment groups (p = 0.0005). Dentin bridge formation was observed in the MTA-treated group. The local action of HA/β-TCP/C is similar to that of MTA when used as an agent for pulp vital treatment in terms of absence of inflammation and maintenance of pulp vitality, although there are significant differences between both materials regarding the formation of dentin bridges.

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“…Several studies have considered AH Plus as the gold standard, given its excellent physical properties and sealing ability [ 5 , 6 , 7 ]. Considering that endodontic failure occurs mainly due to bacteria remaining in the canal, functional root canal sealers with antibacterial effects have also been recently investigated as a strategy for better root canal therapy [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Another improvement in root canal sealers for increasing the success rate of endodontic treatment is the addition of calcium silicate powders to resin-based sealers to accelerate biological functionalities (osteoconductivity or osteoinductivity), which are known as calcium silicate-based sealers [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Physical Properties and Biofunctionalities of Bioactive Root Canal Sealers In Vitro

Kim

Lee

et al. 2020

Nanomaterials

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Calcium silicate-based bioactive glass has received significant attention for use in various biomedical applications due to its excellent bioactivity and biocompatibility. However, the bioactivity of calcium silicate nanoparticle-incorporated bioactive dental sealer is not much explored. Herein, three commercially available bioactive root canal sealers (Endoseal MTA (EDS), Well-Root ST (WST), and Nishika Canal Sealer BG (NBG)) were compared with a resin-based control sealer (AH Plus (AHP)) in terms of physical, chemical, and biological properties. EDS and NBG showed 200 to 400 nm and 100 to 200 nm nanoparticle incorporation in the SEM image, respectively, and WST and NBG showed mineral deposition in Hank’s balanced salt solution after 28 days. The flowability and film thickness of all products met the ISO 3107 standard. Water contact angle, linear dimensional changes, and calcium and silicate ion release were significantly different among groups. All bioactive root canal sealers released calcium ions, while NBG released ~10 times more silicon ions than the other bioactive root canal sealers. Under the cytocompatible extraction range, NBG showed prominent cytocompatibility, osteogenecity, and angiogenecity compared to other sealers in vitro. These results indicate that calcium silicate nanoparticle incorporation in dental sealers could be a potential strategy for dental periapical tissue regeneration.

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Incorporating N-acetylcysteine and tricalcium phosphate into epoxy resin-based sealer improved its biocompatibility and adhesiveness to radicular dentine

Cited by 13 publications

References 23 publications

The effect of N-acetylcysteine on the antibacterial capability and biocompatibility of nano silver–containing orthodontic cement

The effect of N-acetylcysteine on the antibacterial capability and biocompatibility of nano silver–containing orthodontic cement

Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars

Physical Properties and Biofunctionalities of Bioactive Root Canal Sealers In Vitro

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