Although psychology and religion deal with overlapping subject matter, the relationship between psychology and the church has a tumultuous history. The current study examined religious leaders' attitudes toward integrating psychological science into church ministry. Religious leaders (N ϭ 394) completed measures of (a) congregants' mental health and social concerns, (b) attitudes toward psychological science (i.e., perceived barriers of integration, compatibility with church ministry), and (c) hypothesized predictors of attitudes toward the integration of psychology and church ministry (i.e., political conservatism, intratextual fundamentalism, religious intellectual humility, emotional intelligence). Overall, religious leaders expressed both positive and negative attitudes toward psychology. Conservative political orientation and intratextual fundamentalism were associated with negative attitudes toward integration, whereas religious intellectual humility and emotional intelligence were associated with positive attitudes. We conclude by discussing limitations, suggestions for future research, and practical applications for psychologists and church leaders.