Incorporating Clinical Imaging into the Delivery of Microbeam Radiation Therapy

Paino, Jason; Barnes, Micah; Engels, Elette; Davis, Joel; Guatelli, Susanna; Veer, Michael de; Hall, Chris; Häusermann, Daniel M.; Tehei, Moeava; Corde, Stéphanie; Rosenfeld, Anatoly; Lerch, Michael L. F

doi:10.3390/app11199101

Cited by 5 publications

(16 citation statements)

References 36 publications

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“…Measurement uncertainties (as described in Section 2.4.1) are shown for each axis; the three errors are combined in quadrature to give the total uncertainty in the 3D measurement. al., 2020; Paino et al, 2021). In each study, the image guidance provided by SyncMRT allowed for the accurate alignment of tumours to the synchrotron beam.…”

Section: Discussionmentioning

confidence: 99%

“…Although SyncMRT has been used in several experiments over the past four years, only one study (Paino et al, 2021) has presented and collected results for a QA protocol similar to those described in this paper. As such, there are no existing studies, published or unpublished, that we can draw data from.…”

Section: Discussionmentioning

confidence: 99%

“…The work presented in this study provides a foundation for high-quality image guidance in pre-clinical studies. Recently, Paino et al used SyncMRT and the quality assurance protocols described in this work to develop a comprehensive image guidance and treatment delivery protocol for the irradiation of tumour-bearing rats receiving MRT on the IMBL (Paino et al, 2021;Engels et al, 2020). In their work, they explored the effects of CT reconstruction algorithms, X-ray imaging doses (from both CT and locally acquired images with the kilovoltage X-ray tube) and image guidance and treatment delivery accuracies.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous MRT studies went on to demonstrate a unique tumoricidal effect, whereby a differential response was observed between normal and tumour tissue (Crosbie et al, 2010;Dilmanian et al, 2002;Laissue et al, 1998). Since then, many studies have investigated the use of MRT to treat various tumour-bearing rodents (Trappetti et al, 2021;Bouchet et al, 2010;Fernandez-Palomo et al, 2020a,b;Schu ¨ltke et al, 2008;Ibahim et al, 2016;Yang et al, 2019;Engels et al, 2020;Paino et al, 2021). Although these studies have reported key biological findings that solidify the clinical usefulness of MRT, some of these studies have concluded that image guidance (Engels et al, 2020;Paino et al, 2021) and conformal fields (Bouchet et al, 2010) are necessary in order to ensure tumour coverage whilst reducing the irradiation of healthy tissues.…”

Section: Introductionmentioning

confidence: 99%

“…Since then, many studies have investigated the use of MRT to treat various tumour-bearing rodents (Trappetti et al, 2021;Bouchet et al, 2010;Fernandez-Palomo et al, 2020a,b;Schu ¨ltke et al, 2008;Ibahim et al, 2016;Yang et al, 2019;Engels et al, 2020;Paino et al, 2021). Although these studies have reported key biological findings that solidify the clinical usefulness of MRT, some of these studies have concluded that image guidance (Engels et al, 2020;Paino et al, 2021) and conformal fields (Bouchet et al, 2010) are necessary in order to ensure tumour coverage whilst reducing the irradiation of healthy tissues. Despite the evident need for a comprehensive image-guided radiotherapy (IGRT) solution, very few studies have detailed the image guidance protocols used and the achieved geometric treatment accuracies.…”

Section: Introductionmentioning

confidence: 99%

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SyncMRT: a solution to image-guided synchrotron radiotherapy for quality assurance and pre-clinical trials

et al. 2022

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In this work, a new image guidance system and protocols for delivering image-guided radiotherapy (IGRT) on the Imaging and Medical Beamline (IMBL) at the ANSTO Australian Synchrotron are introduced. The image guidance methods used and the resulting accuracy of tumour alignment in in vivo experiments are often under-reported. Image guidance tasks are often complex, time-consuming and prone to errors. If unchecked, they may result in potential mis-treatments. We introduce SyncMRT, a software package that provides a simple, image guidance tool-kit for aligning samples to the synchrotron beam. We have demonstrated sub-millimetre alignment using SyncMRT and the small-animal irradiation platform (the DynamicMRT system) on the IMBL. SyncMRT has become the standard for carrying out IGRT treatments on the IMBL and has been used in all pre-clinical radiotherapy experiments since 2017. Further, we introduce two quality assurance (QA) protocols to synchrotron radiotherapy on the IMBL: the Winston-Lutz test and hidden target test. It is shown that the presented QA tests are appropriate for picking up geometrical setup errors and assessing the end-to-end accuracy of the image guidance process. Together, these tools make image guidance easier and provide a mechanism for reporting the geometric accuracy of synchrotron-based IGRT treatments. Importantly, this work is scalable to other delivery systems, and is in continual development to support the upcoming veterinary radiotherapy trials on the IMBL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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SyncMRT: a solution to image-guided synchrotron radiotherapy for quality assurance and pre-clinical trials

et al. 2022

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Characterization of selected additive manufacturing materials for synchrotron monochromatic imaging and broad-beam radiotherapy at the Australian synchrotron-imaging and medical beamline

Bustillo,

Paino,

Barnes

et al. 2024

Phys. Med. Biol.

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Objective: This study aims to characterize radiological properties of selected additive manufacturing (AM) materials utilizing both material extrusion and vat photopolymerization technologies. Monochromatic synchrotron X-ray images and synchrotron treatment beam dosimetry were acquired at the hutch 3B of the Australian synchrotron - imaging and medical beamline (AS-IMBL).Approach: Eight energies from 30 keV up to 65 keV were used to acquire the attenuation coefficients of the AM materials. Comparison of theoretical, and experimental attenuation data of AM materials and standard solid water for MV linac was performed. Broad-beam dosimetry experiment through attenuated dose measurement and a Geant4 Monte Carlo simulation were done for the studied materials to investigate its attenuation properties specific for a 4 tesla wiggler field with varying synchrotron radiation beam qualities.Main results: PLA plus matches attenuation coefficients of both soft tissue and brain tissue, while ABS, ASA, and Draft resin have close equivalence to adipose tissue. Lastly, PLA, CPE plus, TPU, and White resins are promising substitute materials for breast tissue. For broad-beam experiment and simulation, many of the studied materials were able to simulate RMI457 SolidWater and bolus within +/-10% for the three synchrotron beam qualities. These results are useful in fabricating phantoms for synchrotron and other related medical radiation applications such as orthovoltage treatments. Significance and conclusion: These 3D printing materials were studied as potential substitutes for selected tissues such as breast tissue, adipose tissue, soft-tissue, and brain tissue useful in fabricating 3D printed phantoms for synchrotron imaging, therapy, and orthovoltage applications. Fabricating customizable heterogeneous anthropomorphic phantoms (e.g. breast, head, thorax) and pre-clinical animal phantoms (e.g. rodents, canine) for synchrotron imaging and radiotherapy using AM can be done based on the results of this study.

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Special Issue on Synchrotron Radiation for Medical Applications

Orion

2023

Applied Sciences

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Incorporating Clinical Imaging into the Delivery of Microbeam Radiation Therapy

Cited by 5 publications

References 36 publications

SyncMRT: a solution to image-guided synchrotron radiotherapy for quality assurance and pre-clinical trials

SyncMRT: a solution to image-guided synchrotron radiotherapy for quality assurance and pre-clinical trials

Characterization of selected additive manufacturing materials for synchrotron monochromatic imaging and broad-beam radiotherapy at the Australian synchrotron-imaging and medical beamline

Special Issue on Synchrotron Radiation for Medical Applications

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