The Men Who Have Sex with Men (MSM) lives in irrational stigma of sexual behavior where the community does not have a complete knowledge about MSM sexual behavior. This study aimed to describe MSM's sexual behavior, knowledge, and perception of reproduction health. This study was designed as systematic review among studies from 2015-2018. This study revealed that there growing trends concerning unprotected anal sex and unprotected anal sex with an HIV-discordant partner, exacerbated by a decreasing trend of medication compliance among MSM with HIV. Although MSM has a good level of knowledge, they have a low level of discipline in applying their knowledge about safety sex and medications compliance. This implies that actions are needed to raise awareness about reproductive health and safer sex among MSM, along with awareness for medication compliance among MSM with HIV .