Inconsequential role for chemerin‐like receptor 1 in the manifestation of ozone‐induced lung pathophysiology in male mice
Richard A. Johnston,
Albert W. Pilkington,
Constance L. Atkins
et al.
Abstract:We executed this study to determine if chemerin‐like receptor 1 (CMKLR1), a Gi/o protein‐coupled receptor expressed by leukocytes and non‐leukocytes, contributes to the development of phenotypic features of non‐atopic asthma, including airway hyperresponsiveness (AHR) to acetyl‐β‐methylcholine chloride, lung hyperpermeability, airway epithelial cell desquamation, and lung inflammation. Accordingly, we quantified sequelae of non‐atopic asthma in wild‐type mice and mice incapable of expressing CMKLR1 (CMKLR1‐def… Show more
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