Incomplete Tolerance to MHC Antigens in Irradiation Chimeras: Implications for MHC Restriction and Self Tolerance

Blanden, Robert V.; Ashman, R. B.; O’Neill, Helen C.; Woodhams, Cathy E.; Kees, Ursula R.; Andrew, Morag

doi:10.1111/j.1600-065x.1981.tb00348.x

Cited by 10 publications

(9 citation statements)

References 28 publications

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“…This latter, in particular, may lead to a breakdown in the mechanisms controlling the auto-reactive cells (15). In vitro culture has been shown to permit the expression of anti-self reactivity in other systems in which peripheral suppression has been inferred to be operational (16); however, suppressor cells can also be induced in the absence of significant proliferation (17). Therefore, in the Candida model, the CD8+ cells could possibly be involved in regulation of the crossreactive T cell response, but unfortunately, the heterogeneity of the cell populations has so far prevented identification and detailed analysis of the mechanisms involved in these responses.…”

Section: Discussionmentioning

confidence: 99%

Murine candidiasis: Susceptibility is associated with the induction of T cell‐mediated, strain‐specific autoreactivity

Ashman¹

1990

Immunology & Cell Biology

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Summary Inbred mice can be classified as susceptible or resistant to systemic infection with the yeast Candida albicans by histopathological evaluation of tissue lesions. Candida-specific memory T cell responses generated by resistant BALB/c mice are vigorous and sustained, whereas those displayed by susceptible CBA/H mice are weak. When spleen cells from immune mice were activated by culture with Candida antigens in vitro, and injected into syngeneic and allogeneic recipients in the absence of further antigenic stimulation, cells from CBA/H mice induced a specific inflammatory response only in CBA/H recipients. In contrast, cells from immune BALB/c mice showed no specific activity. The effector cells were identified as T cells of the cytotoxic/suppressor subclass (CD4-, CD8+); and analysis in various Fl hybrid mice showed that reactivity was expressed only in animals carrying CBA/H genes. The data thus indicate that susceptibility to C albicans infection is associated with the induction of a T cell subpopulation that has the potential to react specifically against unmodified self antigens expressed by the susceptible strain.

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Section: Discussionmentioning

confidence: 99%

Murine candidiasis: Susceptibility is associated with the induction of T cell‐mediated, strain‐specific autoreactivity

Ashman¹

1990

Immunology & Cell Biology

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“…If thymic APC are involved in the establishment of self tolerance, a postulate consistent with the negative selection hypothesis implicity accepted by Blanden et al (1981), then these latter resuUs could be explained as foUows. Shortly after reconstitution, the thymic APC are still of donor type.…”

mentioning

confidence: 85%

“…Semiallogeneic radiation chimeras display incomplete tolerance to the second parental haplotype, as demonstrated by the rejection of P2 skin (Boyse et al, 1970;Blanden et al, 1981). If thymic APC are involved in the establishment of self tolerance, a postulate consistent with the negative selection hypothesis implicity accepted by Blanden et al (1981), then these latter resuUs could be explained as foUows.…”

mentioning

confidence: 92%

“…However, skin grafting between congenic strains of mice, as well as additional data (Blanden et al, 1981), showed clearly that the target antigens were coded within the major histocompatibility complex. These results were consistent with the hypothesis that there existed, within the chimeras, cells with the potential to react against self and that these cells were subject to some form of suppression.…”

Section: Stein Graftingmentioning

confidence: 99%

“…Surviving chimeras were then regrafted and observed for a, further 105 days. At the conclusion of the experiment the chimeras were typed using a sensitive rosetting assay that can give quantitative estimates of H-2 antigen concentration relative to Fl controls (Parish and McKenzie, 1978;Blanden et al, 1981). All of the animals typed fell within the normal range for (C57BI/6J X BALB/c)Fl mice.…”

Section: Stein Graftingmentioning

confidence: 99%

See 2 more Smart Citations

Failure to Modify Anti‐p2 Reactivity in Long‐term (P1 × P2)f1→p1 Radiation Chimeras by Total Lymphoid Cell Ablation: Implications for the Role of Thymic Antigen‐presenting Cells

Ashman

1983

Aust J Exp Biol Med

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Absence of suppression in natural and induced tolerance to F antigen

Nardi

1984

Immunogenetics

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The role of suppression in natural and induced tolerance to F antigen was investigated in two sets of experiments. In the first, CBA mice were submitted to pretreatments which decrease suppression and the antibody response to self- or allo-F type was investigated. The second set of experiments involved the transfer of spleen cells from tolerized or from naturally tolerant mice into normal mice which were then primed with allo-F, as well as the co-transfer of tolerant and primed lymphocytes into normal mice, to test whether tolerant lymphocytes present suppressor cells. The results indicate that the immune response against allo-F antigen is normally kept in a low level by a suppressive mechanism, and that F-specific suppressor T cells are absent from tolerant mice.

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Incomplete Tolerance to MHC Antigens in Irradiation Chimeras: Implications for MHC Restriction and Self Tolerance

Cited by 10 publications

References 28 publications

Murine candidiasis: Susceptibility is associated with the induction of T cell‐mediated, strain‐specific autoreactivity

Murine candidiasis: Susceptibility is associated with the induction of T cell‐mediated, strain‐specific autoreactivity

Failure to Modify Anti‐p2 Reactivity in Long‐term (P1 × P2)f1→p1 Radiation Chimeras by Total Lymphoid Cell Ablation: Implications for the Role of Thymic Antigen‐presenting Cells

Absence of suppression in natural and induced tolerance to F antigen

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