Incomplete remyelination via endogenous or therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function
Gustavo Della-Flora Nunes,
Lindsay A Osso,
Johana A Haynes
et al.
Abstract:Myelin loss induces deficits in action potential propagation that result in neural dysfunction and contribute to the pathophysiology of neurodegenerative diseases, injury conditions, and aging. Because remyelination is often incomplete, better understanding endogenous remyelination and developing remyelination therapies that seek to restore neural function are clinical imperatives. Here, we usedin vivotwo-photon microscopy and electrophysiology to study the dynamics of endogenous and therapeutic-induced cortic… Show more
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