Incomplete Posterior Hyaloid Detachment after Intravitreal Pegaptanib Injection in Diabetic Macular Edema

Montero, J A; Ruiz-Moreno, José M.; Vega, Concepción de la

doi:10.1177/112067210801800328

Cited by 8 publications

(6 citation statements)

References 5 publications

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“…3 Posterior hyaloid adhesions also play a role in the pathogenesis of DDME. 4 Therefore, DDME can be classified according to differences in pathogenesis, and treatments for DDME may depend on this classification. 5 Although recent studies have shown the effectiveness of intravitreal bevacizumab (IVB) in reducing DDME, 6,7 clinical experience reveals that sometimes "persistent" DDME occurs, even after bevacizumab injection.…”

mentioning

confidence: 99%

Visual Outcome After Intravitreal Bevacizumab Depends on the Optical Coherence Tomographic Patterns of Patients With Diffuse Diabetic Macular Edema

Shimura

Yasuda

et al. 2013

Retina

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mentioning

confidence: 99%

Visual Outcome After Intravitreal Bevacizumab Depends on the Optical Coherence Tomographic Patterns of Patients With Diffuse Diabetic Macular Edema

Shimura

Yasuda

et al. 2013

Retina

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“…2 Additionally, increased vascular permeability in the retina and/or retinal neovascularization are related to DDME, 3 and posterior hyaloid adhesions also play a role in the pathogenesis of DDME. 4 Therefore, DDME can be classified according to differences in pathogenesis, and treatment of DDME possibly depends on this classification.…”

mentioning

confidence: 99%

Visual Outcome After Intravitreal Triamcinolone Acetonide Depends on Optical Coherence Tomographic Patterns in Patients With Diffuse Diabetic Macular Edema

Shimura¹,

Yasuda²,

Nakazawa³

et al. 2011

Retina

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“…It occurs mainly as a result of blood retinal barrier disruption leading to an increased accumulation of fluid within the intraretinal layers of the macula [3]. Although a disruption in the blood retinal barrier plays the main role in the pathogenesis of DME, vitreomacular interface changes [4], hypoxia, altered blood flow, retinal ischemia, and inflammation are also associated with the progression of DME. Therefore many treatments have been suggested and attempted, such as laser photocoagulation, intravitreal steroid injection, intravitreal anti-vascular endothelial growth factor (anti-VEGF) injection, and pars plana vitrectomy.…”

mentioning

confidence: 99%

Efficacy of Intravitreal Anti-vascular Endothelial Growth Factor or Steroid Injection in Diabetic Macular Edema According to Fluid Turbidity in Optical Coherence Tomography

Lee

Chung

Park

et al. 2014

Korean J Ophthalmol

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PurposeTo determine if short term effects of intravitreal anti-vascular endothelial growth factor or steroid injection are correlated with fluid turbidity, as detected by spectral domain optical coherence tomography (SD-OCT) in diabetic macular edema (DME) patients.MethodsA total of 583 medical records were reviewed and 104 cases were enrolled. Sixty eyes received a single intravitreal bevacizumab injection (IVB) on the first attack of DME and 44 eyes received triamcinolone acetonide treatment (IVTA). Intraretinal fluid turbidity in DME patients was estimated with initialintravitreal SD-OCT and analyzed with color histograms from a Photoshop program. Central macular thickness and visual acuity using a logarithm from the minimum angle of resolution chart, were assessed at the initial period and 2 months after injections.ResultsVisual acuity and central macular thickness improved after injections in both groups. In the IVB group, visual acuity and central macular thickness changed less as the intraretinal fluid became more turbid. In the IVTA group, visual acuity underwent less change while central macular thickness had a greater reduction (r = -0.675, p = 0.001) as the intraretinal fluid was more turbid.ConclusionsIVB and IVTA injections were effective in reducing central macular thickness and improving visual acuity in DME patients. Further, fluid turbidity, which was detected by SD-OCT may be one of the indexes that highlight the influence of the steroid-dependent pathogenetic mechanism.

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Incomplete Posterior Hyaloid Detachment after Intravitreal Pegaptanib Injection in Diabetic Macular Edema

Abstract: PHD may play an important role in cases where macular thickness is successfully reduced or better acuity is achieved after intravitreal injections.

Cited by 8 publications

References 5 publications

Visual Outcome After Intravitreal Bevacizumab Depends on the Optical Coherence Tomographic Patterns of Patients With Diffuse Diabetic Macular Edema

Visual Outcome After Intravitreal Bevacizumab Depends on the Optical Coherence Tomographic Patterns of Patients With Diffuse Diabetic Macular Edema

Visual Outcome After Intravitreal Triamcinolone Acetonide Depends on Optical Coherence Tomographic Patterns in Patients With Diffuse Diabetic Macular Edema

Efficacy of Intravitreal Anti-vascular Endothelial Growth Factor or Steroid Injection in Diabetic Macular Edema According to Fluid Turbidity in Optical Coherence Tomography

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