Incomplete Hippocampal Inversion: A Neurodevelopmental Mechanism for Hippocampal Shape Deformation in Schizophrenia

Synaptic Terminal Density Early in the Course of Schizophrenia: An In Vivo UCB-J Positron Emission Tomographic Imaging Study of SV2A

“…Thus, the early-course group reported on here showed greater symptom severity than the chronic SCZ group that we reported on previously. The significant negative relationship between PANSS total scores and [ 11 C]UCB-J V T in the hippocampus confirmed our hypothesis that SV2A levels are inversely associated with symptom severity, thereby extending preclinical and clinical evidence implicating hippocampal dysfunction in SCZ ( 14 , 22 , 23 , 24 , 25 ), but contrasting with SV2A findings in chronic patients ( 7 ). Speculatively, these findings could suggest that SV2A levels are related to the disease process in early-course but not in chronic SCZ.…”

Smaller anterior hippocampal subfields in the early stage of psychosis

“…HC participants were excluded if they met criteria for any Axis I disorder or had a first-degree relative with a known psychotic disorder. Data from a subset of participants in this cohort have been included in previous reports on hippocampal volume (N overlap = 122) [ 21 , 30 ] and incomplete hippocampal inversion (N overlap = 131) [ 62 , 64 ], but the T2-weighted scans and analyses presented here are novel. All participants provided written informed consent and received monetary compensation for their time.…”