Incompatibility of contrast agents with intravascular medications. Work in progress.

Abstract

In vitro and in vivo precipitation of iodinated contrast agents when ioxaglate and papaverine are given together has been reported. To verify these reports and to investigate other medications not previously tested, the authors analyzed mixtures of contrast agents and medications in vitro with a light spectrophotometer and observed them for visible precipitates for up to 120 minutes. Previously reported incompatibilities between ionic or low-osmolality contrast media and medications were verified, and several new incompatibilities were discovered. No incompatibilities were found when the drugs tested were mixed with the new nonionic contrast media.

Polysaccharide-Based Theranostic Systems for Combined Imaging and Cancer Therapy: Recent Advances and Challenges

“…In the field of radiology, contrast agents and medications are frequently infused with indwelling intravenous lines. Incongruity between the contrast media and therapeutic molecules could result in precipitation which may have severe consequences like obstruction of the intravenous line, inactivation of the medication, and embolism . Choice of contrast agent and drug is very important when designing theranostic systems, as incompatibility among them may lead to severe consequences including discomfort for the patient and fatality.…”