We introduce a hierarchy of split principles and show that it parallels the hierarchy of large cardinals. In the typical case, a cardinal being large is equivalent to the corresponding split principle failing. As examples, we show how inaccessibility, weak compactness, subtlety, almost ineffability and ineffability can be characterized. We also consider two-cardinal versions of these principles. Some natural notions in the split hierarchy correspond to apparently new large cardinal notions. Such split principles come with certain ideals, and one of the split principles characterizing a version of κ being λ-Shelah gives rise to a normal ideal on Pκλ. We also investigate the splitting numbers and the ideals induced by these split principles, and the relationship to partition relations.