Incoherent Optical Fluctuation Flowmetry: A New Method for the Assessment of Foot Perfusion in Patients with Diabetes-Related Lower-Extremity Complications

Abstract

(1) Background: To date, there are no studies evaluating the ability of the incoherent optical fluctuation flowmetry (IOFF) method to assess foot tissue perfusion. The aim of this study was to evaluate the correlation between perfusion values measured by IOFF and TcPO2 in patients with diabetes-related lower-extremity complications. (2) Methods: This was an observational, cross-sectional, two-center study. Diabetic patients with peripheral artery disease and/or diabetic foot ulcers were studied (n = 27, examinations were carried out on 54 legs). Perfusion in the foot tissues was assessed using TcPO2 (reference standard for this study) and the IOFF method. (3) Results: High correlation coefficients of all perfusion parameters measured by IOFF with TcPO2 (Rs 0.7 to 0.76) were shown. The study demonstrated that the IOFF method allows, with a sensitivity of 85.7% and a specificity of 90.0%, the identification of patients with a critical decrease in TcPO2 < 20 mmHg. (4) Conclusions: The high correlation of IOFF parameters with TcPO2 and the moderately high sensitivity and specificity in detecting patients with severe ischemia of foot tissues shows the promise of the method for assessing a tissue perfusion in patients with diabetes-related lower-extremity complications.

Wireless Dynamic Light Scattering Sensors Detect Microvascular Changes Associated With Ageing and Diabetes

“…Other methods based on the use of biophotonic techniques are also known for diagnosing the state of microcirculatory function in DM. For example, in the studies by Dremin et al [48] and Glazkova et al [54], LDF was used in conjunction with the local heating test, which resulted in sensitivity and specificity values of up to 0.92 and 0.90 respectively, and AUC values of up to 0.94. Evaluation of blood volume fraction and skin blood oxygenation simultaneously with measurement of the polarisation index of light reflected from the skin resulted in a sensitivity of 0.95 and specificity of 0.85 [55].…”

Lesion Detection and Analysis Using Optical Imaging

“…The authors concluded that the lens of women and people of color had a higher attenuation during DECT, which may indicate a higher density or increased calcium concentration and a high probability of cataract formation. P. Glazkova et al studied the possibilities of incoherent optical fluctuation flowmetry (IOFF) to analyze the perfusion of foot tissues in patients with diabetes mellitus [23]. Perfusion in foot tissues was also assessed using transcutaneous oxygen pressure measurements (TcPO 2 ) as a reference standard.…”