Inclusion of the parent molecules of some drugs with β-cyclodextrin studied by electrochemical and spectrometric methods

Dang, Xiaojun; Nie, Mengyan; Tong, Jian; Li, Hu‐Lin

doi:10.1016/s0022-0728(97)00516-0

Cited by 56 publications

(24 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Firstly, these data are consistent with the formation of an inclusion complex between the DA and the sulfonated ␤-CD. Similar changes in the peak currents and potentials have been reported previously with other host-guest systems [22,23]. In particular, Dang et al [22] reported similar results for the complexation of benzoquinone and anthraquinone with neutral ␤-CD.…”

Section: Evidence For the Formation Of An Inclusion Complexsupporting

confidence: 84%

“…Similar changes in the peak currents and potentials have been reported previously with other host-guest systems [22,23]. In particular, Dang et al [22] reported similar results for the complexation of benzoquinone and anthraquinone with neutral ␤-CD. A similar trend was observed by Gao et al [23] in studying the complexation of basic brown G with ␤-CD.…”

Section: Evidence For the Formation Of An Inclusion Complexsupporting

confidence: 84%

See 1 more Smart Citation

An electrochemical study in aqueous solutions on the binding of dopamine to a sulfonated cyclodextrin host

Hendy

Breslin

2012

Electrochimica Acta

View full text Add to dashboard Cite

a b s t r a c tClear evidence for the formation of a weak inclusion complex between dopamine (DA) and a sulfonated ␤-CD host in aqueous solution was obtained using a combination of electrochemical approaches. Using cyclic voltammetry, a distinct increase in the oxidation potential of DA and a reduction in the peak oxidation current were observed on adding an excess concentration of the sulfonated ␤-CD to the electrolyte solution. Equally, a clear increase in the half-wave oxidation potential of DA was observed in the presence of the sulfonated ␤-CD using rotating disc voltammetry. The association constant, K, was computed as 331.3 ± 5.8, indicating the formation of a weak inclusion complex, while a 1:1 stoichiometry for the inclusion complex was deduced from a Job's plot analysis. The rate constant for the oxidation of DA was found to decrease on formation of the inclusion complex. This was attributed to higher reorganization energy for the oxidation of the included DA. These changes in the electrochemistry of DA were not observed when an excess of the smaller sulfonated ␣-CD was added to the electrolyte, indicating that these variations are not connected with simple electrostatic interactions between the protonated DA and the anionic sulfonated groups. It is proposed that the aromatic ring of the DA molecule includes within the cyclodextrin cavity, while the protonated amine group remains outside the cavity, bound electrostatically with the anionic sulfonated groups.

show abstract

Section: Evidence For the Formation Of An Inclusion Complexsupporting

confidence: 84%

Section: Evidence For the Formation Of An Inclusion Complexsupporting

confidence: 84%

An electrochemical study in aqueous solutions on the binding of dopamine to a sulfonated cyclodextrin host

Hendy

Breslin

2012

Electrochimica Acta

View full text Add to dashboard Cite

show abstract

“…4(b)). This reduction in the peak current and the anodic shift of the peak potentials for the oxidation of the analyte are consistent with the formation of an inclusion complex [42,43]. The increase in the oxidation potential is connected to the fact that it is more difficult to oxidise the included dopamine, while the decrease in the peak currents is consistent with a lower diffusion coefficient of the included dopamine compared to that of free dopamine.…”

Section: Mechanism Of Sensingsupporting

confidence: 70%

The selective detection of dopamine at a polypyrrole film doped with sulfonated β-cyclodextrins

Harley

Rooney

Breslin

2010

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

a b s t r a c t A highly selective dopamine sensor was fabricated by doping polypyrrole with a sulfonated ␤-cyclodextrin. This composite material enabled the selective sensing of dopamine in the presence of a large excess of ascorbic acid and prevented the regeneration of dopamine through the homogeneous catalytic reaction of the ascorbate anion with the dopamine-o-quinone. A single redox wave, corresponding to the oxidation of dopamine, was observed in dopamine/ascorbate mixtures, giving a truly selective dopamine sensor. The limit of detection was measured as 3.2 × 10 −6 M for dopamine.

show abstract

“…The inclusion of some pharmaceutically related molecules, such as 1,4-benzoquinone (BQ), 9,10-anthraquinone (AQ), anthracene (AN), acridine (AC), phenothiazine (PT) and thianthrene (TH) within -cyclodextrin ( -CD) has been investigated using an electrochemical method [57]. From the decrease in the peak current, the formation constants (K f ) of these inclusion complexes were obtained.…”

Section: Electrochemicalmentioning

confidence: 99%

Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds

Radi¹

2010

TOCBMJ

View full text Add to dashboard Cite

Electrochemistry of cyclodextrins (CDs) and cyclodextrin inclusion complexes with different pharmaceutical compounds is reviewed. The article highlights some electrochemical investigations of the CD-drugs interactions in solution. Cyclodextrin modified electrodes and their applications as electrochemical sensors in pharmaceutical analysis based on the self-assembly of CD derivatives on metal electrodes and nanoparticles, and cyclodextrin-modified multiwalled carbon nanotubes are also discussed.

show abstract

Inclusion of the parent molecules of some drugs with β-cyclodextrin studied by electrochemical and spectrometric methods

Cited by 56 publications

References 13 publications

An electrochemical study in aqueous solutions on the binding of dopamine to a sulfonated cyclodextrin host

An electrochemical study in aqueous solutions on the binding of dopamine to a sulfonated cyclodextrin host

The selective detection of dopamine at a polypyrrole film doped with sulfonated β-cyclodextrins

Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds

Contact Info

Product

Resources

About