Inclusion of memory effects in a dynamic model of electroporation in biological tissues

Abstract

This article presents experimental and computational results of electroporation in rat liver. The experiments were performed using different forms of electrodes and waveforms of applied electric pulses. For the numerical simulation, the electroporation model proposed by Ramos and Weinert in a previous publication was used. Dynamic adjustments were used for obtaining a good modeling of the electric current. A single set of model parameters was obtained to fit the simulated current response for different waveforms and electrodes. These parameters were obtained with the use of a genetic algorithm that minimized the error between the simulated and experimental currents. The electroporation model with dynamic adjustment proved to be an appropriate simulation tool to predict the tissue conductivity during stimulation by intense electrical fields.

Dynamic Electroporation Model Evaluation on Rabbit Tissues

“…7 The model contains six parameters and obtained a good representation for the electric current in the sample for one pulse of the applied field. Weinert et al 33 proposed dynamic changes in the parameters of the model by Ramos and Weinert, 27 obtaining good agreement between numerical and experimental results for the electric current in the sequence of ten pulses. However, the model has become complex, increasing the number of parameters to be adjusted.…”

“…The starting point for the parameter values was obtained from the work of Weinert et al 33 Small adjustments in the parameters were necessary to decrease the error between the experimental and simulated data. The parameters of the model depend on the type of tissue and the applied field strength.…”

Artificial Organs 2019: A year in review

“…Rodolfo Weinert et al of the Universidade do Estado de Santa Catarina, Joinville, Brazil presented experimental and computational results of electroporation in rat liver. A single set of model parameters was obtained to fit the simulated current response for different waveforms and electrodes.…”