Inclusion of chemotherapeutic agents in substituted β-cyclodextrin derivatives

Thiele, Carolin; Auerbach, Dagmar; Jung, Gregor; Wenz, Gerhard

doi:10.1007/s10847-010-9741-4

Cited by 23 publications

(17 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The higher binding potentials of the β-CD thioethers 3 and 4 compared to native β-CD could be attributed both to the higher hydrophobicity of sulfur compared to oxygen and to the exclusive localization of the substituents in position 6. This finding is consistent with previous observations of the high binding potentials of CD thioethers for other guests [32–33 39]. The binding constants of the neutral thioether 3 were in most cases higher than the ones of the anionic thioether 4 .…”

Section: Resultssupporting

confidence: 93%

See 1 more Smart Citation

Space filling of β-cyclodextrin and β-cyclodextrin derivatives by volatile hydrophobic guests

Fourmentin¹,

Ciobanu

Landy³

et al. 2013

Beilstein J. Org. Chem.

Self Cite

View full text Add to dashboard Cite

SummaryThe inclusion of volatile derivatives of benzene and cyclohexane in β-cyclodextrin (β-CD), hydroxypropyl-β-CD, and hydrophilic β-CD-thioethers was investigated by static headspace gas chromatography (HS-GC) and molecular modelling. The obtained binding constants strongly increase with the amount of space filling of the CD cavity and the salt concentration. β-CD thioethers show a 3–10 times higher binding potential than native β-CD.

show abstract

Section: Resultssupporting

confidence: 93%

“…1) for the solubilization of sparingly water-soluble drugs [32–33]. These β-CD-thioethers are single pure compounds and they showed very promising binding constants and very high aqueous solubility.…”

Section: Introductionmentioning

confidence: 99%

Space filling of β-cyclodextrin and β-cyclodextrin derivatives by volatile hydrophobic guests

Fourmentin¹,

Ciobanu

Landy³

et al. 2013

Beilstein J. Org. Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The resulting CD derivatives, such as hydroxypropyl-CD, often show higher solubility in water and lower toxicity than the corresponding native CDs [20]. Amino functionalities have been multivalently attached to CDs via thioether linkages at the primary positions leading to highly water-soluble CD derivatives, which show improved binding affinities and aqueous solubilities compared to native CDs [21][22][23]. CDs can complex not only monomeric guests but also polymeric ones.…”

Section: Introductionmentioning

confidence: 99%

Cellular delivery of polynucleotides by cationic cyclodextrin polyrotaxanes

Dandekar

Jain

Keil

et al. 2012

Journal of Controlled Release

Self Cite

View full text Add to dashboard Cite

Cationic polyrotaxanes, obtained by temperature activated threading of cationic cyclodextrin derivatives onto water soluble cationic polymers (ionenes), form metastable nanometric polyplexes with pDNA and combinations of siRNA with pDNA.Because of their low toxicity, the polyrotaxane polyplexes constitute a very interesting system for the transfection of polynucleotides into mammalian cells. The complexation of Cy3-labeled siRNA within the polyplexes was demonstrated by fluorescence correlation spectroscopy. The uptake of the polyplexes (red) was imaged by confocal fluorescence microscopy using the A549 cell line as a model (blue: nuclei, green: membranes). The results prove the potential of polyrotaxanes for further investigations involving knocking down genes of therapeutic interest.

show abstract

“…It is also well known that paclitaxel (PTX), one of the most common antitumour drugs [18][19][20] , forms an inclusion complex with beta-CD (b-CD), which results in a significant increase in the aqueous solubility of PTX [21][22][23][24][25][26] . Therefore, it is to be expected that multivalent inclusion complexes will form between two functionalized polymers with multiple CDs and multiple PTXs attached to each of the polymer backbones, respectively.…”

mentioning

confidence: 99%

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

et al. 2014

View full text Add to dashboard Cite

Effective anticancer therapy can be achieved by designing a targeted drug-delivery system with high stability during circulation and efficient uptake by the target tumour cancer cells. We report here a novel nano-assembled drug-delivery system, formed by multivalent host-guest interactions between a polymer-cyclodextrin conjugate and a polymer-paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. The ester linkages between paclitaxel and the polymer backbone permit efficient release of paclitaxel within the cell by degradation. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery.

show abstract

Inclusion of chemotherapeutic agents in substituted β-cyclodextrin derivatives

Cited by 23 publications

References 24 publications

Space filling of β-cyclodextrin and β-cyclodextrin derivatives by volatile hydrophobic guests

Space filling of β-cyclodextrin and β-cyclodextrin derivatives by volatile hydrophobic guests

Cellular delivery of polynucleotides by cationic cyclodextrin polyrotaxanes

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

Contact Info

Product

Resources

About