Inclusion complexes and photostability of UV filters and curcumin with beta-cyclodextrin polymers: effect on cross-linkers

Karpkird, Thitinun; Khunsakorn, Raweewan; Noptheeranuphap, Chaiwat; Midpanon, Supatta

doi:10.1007/s10847-018-0796-y

Cited by 16 publications

(6 citation statements)

References 40 publications

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“…The vibrational results are in agreement with the literature. It is not surprising that changes in the guest ring modes were observed; actually, both octinoxate and avobenzone have been reported to penetrate into the hydrophobic cavity of β-CD and γ-CD . Molecular modeling studies for the inclusion complex have shown that the predominant contribution to the E binding comes from the van der Waals forces .…”

Section: Resultsmentioning

confidence: 99%

Environmentally Friendly Sunscreens: Mechanochemical Synthesis and Characterization of β-CD Inclusion Complexes of Avobenzone and Octinoxate with Improved Photostability

D’Agostino

Azzali

Casali

et al. 2020

ACS Sustainable Chem. Eng.

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We report on the mechanochemical synthesis of inclusion complexes obtained by reacting β-cyclodextrin (β-CD) with two widely used sunscreens, namely, avobenzone (AVO) and octinoxate (OCT). Formation of crystalline inclusion complexes was confirmed via a combination of solid-state techniques, including Xray diffraction (XRD), Raman, and ATR-FTIR spectroscopies. A new, metastable polymorph of avobenzone was also isolated and characterized. NMR spectroscopy and thermal analyses (TGA and DSC) allowed us to evaluate the host/guest ratio and the water content (ca. 8H 2 O) in crystalline (β-CD) 2 •AVO and (β-CD) 3 • OCT 2 . Photodegradation of the two sunscreens upon inclusion in the hydrophobic cavity of β-CD was evaluated in solution via mass spectrometry (ESI-MS) and UV−vis spectroscopy and found to be sharply reduced. All findings indicate that the inclusion of AVO and OCT in β-CD might represent a viable route for the preparation of environmentally friendly sunscreens with improved photostability to be used in formulations of sun creams.

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Section: Resultsmentioning

confidence: 99%

Environmentally Friendly Sunscreens: Mechanochemical Synthesis and Characterization of β-CD Inclusion Complexes of Avobenzone and Octinoxate with Improved Photostability

D’Agostino

Azzali

Casali

et al. 2020

ACS Sustainable Chem. Eng.

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“…In addition, combining avobenzone with other photostable filters such as octocrylene and Tinosorb S can also prevent photodegradation [43,44]. Its photostability can also be improved by loading in cyclodextrin, e.g., beta-cyclodextrin polymers (pbCD) crosslinked by epichlorohydrin (pbCDE), or liposome lipid nanoparticles, microparticles, and polymeric nanoparticles [42,45].…”

Section: Discussionmentioning

confidence: 99%

A Survey of UV Filters Used in Sunscreen Cosmetics

Pniewska,

Kalinowska-Lis

2024

Applied Sciences

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The aim of this study was to determine the types of UV filters used in adult and children’s sunscreen products sold in Poland (part of the EU market) and their frequency of use. The INCI compositions of sunscreen products were collected and analyzed for the presence of UV filters. The study included 150 randomly selected preparations for adults (from 71 brands) and 50 for children (from 33 brands). The survey concerned the UV filters listed in Annex VI to Regulation (EC) No 1223/2009 of the European Parliament and Council of 30 November 2009 on cosmetic products. The most frequently used UV filters in the child sunscreens were triazine derivatives: bis-ethylhexyloxyphenol methoxyphenyl triazine (60.0%) and ethylhexyl triazone (52.0%), and ethylhexyl salicylate (46.0%), a derivative of salicylic acid. The most common in adult sunscreens were butyl methoxydibenzoylmethane (56.0%), a dibenzoylmethane derivative, followed by the salicylic acid derivative ethylhexyl salicylate (54.7%) and the triazine derivatives bis-ethylhexyloxyphenol methoxyphenyl triazine (54.7%) and ethylhexyl triazone (50.0%). Physical filters, including their nano and non-nano forms, were more popular in sunscreens for children, i.e., 50.0% (TiO2) and 22.0% (ZnO), than for adults: 21.3% (TiO2) and 6.7% (ZnO). For both adults and children, many cosmetic products contained four or five UV filters per preparation; however, the child preparations often used two UV filters. To summarize, the following UV filters dominate in photoprotectors for both adults and children: butyl methoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, ethylhexyl salicylate, and diethylamino hydroxybenzoyl hexyl benzoate.

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“…Several approaches could be used in order to ameliorate the photostability of photoprotective agents, such as the introduction of antioxidants [ 29 ], encapsulation [ 34 ], multiple association of UV filters [ 35 , 36 , 37 , 38 ], and the addition of quenching molecules [ 39 ] in the sunscreen’s formulation [ 40 ].…”

Section: Challengesmentioning

confidence: 99%

UV Filters: Challenges and Prospects

et al. 2022

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The use of sunscreens is an established and recommended practice to protect skin from solar-induced damage. Around 30 UV filters can be used in sunscreen products in the European Union, which ought to follow the requirements of the regulation 1223/2009 to ensure their efficacy and safety for humans. Nevertheless, low photostability and putative toxicity for humans and environment have been reported for some UV filters. Particularly, the negative impact in marine organisms has recently raised concern on the scientific community. Therefore, it is important to develop new UV filters with improved safety profile and photostability. Over the last two decades, nearly 200 new compounds have revealed promising photoprotection properties. The explored compounds were obtained through different approaches, including exploration of natural sources, synthetic pathways, and nanotechnology. Almost 50 natural products and around 140 synthetic derivatives, such as benzimidazoles, benzotriazoles, hydroxycinnamic acids, xanthones, triazines, among others, have been studied aiming the discovery of novel, effective, and safer future photoprotective agents. Herein, we provide the reader with an overview about UV filters’ challenges and prospects, offering a forward-looking to the next-generation of UV filters.

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Inclusion complexes and photostability of UV filters and curcumin with beta-cyclodextrin polymers: effect on cross-linkers

Cited by 16 publications

References 40 publications

Environmentally Friendly Sunscreens: Mechanochemical Synthesis and Characterization of β-CD Inclusion Complexes of Avobenzone and Octinoxate with Improved Photostability

Environmentally Friendly Sunscreens: Mechanochemical Synthesis and Characterization of β-CD Inclusion Complexes of Avobenzone and Octinoxate with Improved Photostability

A Survey of UV Filters Used in Sunscreen Cosmetics

UV Filters: Challenges and Prospects

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