Inclusion complexation between neurotransmitters with polyacetylated calix[4]pyrogallolarenes: 1H-NMR and crystallographic analysis

Casas-Hinestroza, José Luis; Pérez‐Redondo, Adrián; Maldonado, Mauricio

doi:10.1007/s11164-022-04735-4

Cited by 2 publications

(3 citation statements)

References 41 publications

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“…The stoichiometric relationship was confirmed via electrospray ionization-mass spectrometry, which is a soft ionization technique that allows evaluating this type of interaction, as previously studied with various macrocyclic systems [42][43][44]. The experiments were carried out with different host:guest stoichiometries, producing the same signal for the 1:1 complex in all cases.…”

Section: Molecular Interaction Studies Between Resorcinarenes and L-c...mentioning

confidence: 76%

“…However, as observed by 1 H-NMR, the interaction of carnitine with compounds 4 or 5 was very weak, and no signal could be seen for the complexes with these two resorcinarenes. The stoichiometric relationship was confirmed via electrospray ionization-m trometry, which is a soft ionization technique that allows evaluating this type o tion, as previously studied with various macrocyclic systems [42][43][44]. The exp were carried out with different host:guest stoichiometries, producing the same s the 1:1 complex in all cases.…”

Section: Molecular Interaction Studies Between Resorcinarenes and L-c...mentioning

confidence: 79%

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Evaluation of a Resorcinarene-Based Sorbent as a Solid-Phase Extraction Material for the Enrichment of L-Carnitine from Aqueous Solutions

Ramirez,

Cadavid-Montoya,

Maldonado

2023

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We present five new sorbents for the evaluation of the pre-concentration of L-carnitine. The sorbents were obtained from copolymerization between butylmethacrylate (BuMA) and ethylene dimethacrylate (EDMA), which were physically modified on their surface by each one of the five synthetized resorcinarenes of variable chain length studied, with long-chain resorcinarenes exhibiting better fixation on the copolymer. The characterization of the synthesized resorcinarenes was done using FTIR-ATR, 1H NMR, 13C NMR, and mass spectrometry, while characterization of the sorbents was done using FTIR-ATR and scanning electron micrography (SEM). The molecular interaction between L-carnitine and the synthesized resorcinarenes was studied in DMSO via 1H-NMR spectroscopy and, in the gas phase, via electrospray ionization-mass spectrometry (ESI-MS). The results showed that the short-chain resorcinarenes underwent a stable interaction with the neurotransmitter. Once the sorption of resorcinarenes on the copolymer was accomplished, the best parameters for the evaluation of the L-carnitine preconcentration were established. The solution tests were carried out through LC/MS analysis, obtaining better results for L-carnitine absorption with the short-chain resorcinarenes such as tetra(ethyl)calix[4]resorcinarene and tetra(propyl)calix[4]resorcinarene.

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Section: Molecular Interaction Studies Between Resorcinarenes and L-c...mentioning

confidence: 76%

Section: Molecular Interaction Studies Between Resorcinarenes and L-c...mentioning

confidence: 79%

Evaluation of a Resorcinarene-Based Sorbent as a Solid-Phase Extraction Material for the Enrichment of L-Carnitine from Aqueous Solutions

Ramirez,

Cadavid-Montoya,

Maldonado

2023

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“…Continuing with our research on polyhydroxylated platforms [17][18][19][20], in this article the complexing capacity of three macrocycles systems: 2-hydroxypropyl-α-cyclodextrin, 2hydroxypropyl-β-cyclodextrin and 2-hydroxypropyl-γ-cyclodextrin, with hydrocortisone (Figure 1) were evaluated. The formed complexes were analyzed by using FT-IR and 1 H-NMR spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

New Contributions to the Study of the Interaction between Hydrocortisone and Hydroxypropyl-Cyclodextrins in Aqueous Solution

Maldonado,

Sanabria,

Romero

et al. 2024

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In the present work, the interactions between hydrocortisone and cyclodextrins were investigated. The cyclodextrins selected for this study were hydroxypropyl-α-cyclodextrin, hydroxypropyl-β-cyclodextrin and hydroxypropyl-γ-cyclodextrin. The study was carried out using density measurements, 1H-NMR and FT-IR spectroscopy. Preliminary studies show that hydroxypropyl-α-cyclodextrin has a low affinity for hydrocortisone, while hydroxypropyl-β-cyclodextrin and hydroxypropyl-γ-cyclodextrin have a good affinity for hydrocortisone in both solid state and solution. The study was carried out at two temperatures: 298.15 K and 310.15 K. The results suggest that at both temperatures, the system 2-HP-β-CD + HC induces an increase in the solvent structure, with increasing the solute concentration in the solution, while on the contrary the system 2-HP-γ-CD + HC induces a decrease in the solvent structure when the concentration of the solute in the system increases.

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Inclusion complexation between neurotransmitters with polyacetylated calix[4]pyrogallolarenes: 1H-NMR and crystallographic analysis

Cited by 2 publications

References 41 publications

Evaluation of a Resorcinarene-Based Sorbent as a Solid-Phase Extraction Material for the Enrichment of L-Carnitine from Aqueous Solutions

Evaluation of a Resorcinarene-Based Sorbent as a Solid-Phase Extraction Material for the Enrichment of L-Carnitine from Aqueous Solutions

New Contributions to the Study of the Interaction between Hydrocortisone and Hydroxypropyl-Cyclodextrins in Aqueous Solution

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