Inclusion complex of sulfadimethoxine with cyclodextrins: Preparation and characterization

Rajendiran, N.; Siva, S.

doi:10.1016/j.carbpol.2013.10.016

Cited by 86 publications

(34 citation statements)

References 31 publications

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“…The chemical shifts of the concerned peaks for pure SMM and the SMM-CD complex were obtained as H), where the data in the parenthesis were for the SMM-CD complex 36. It clearly showed that the interaction between SMM and β-CD increased the chemical shifts of H-a, H-e and H-f in SMM by 0.01-0.03 ppm.…”

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confidence: 99%

Preparation of a native β-cyclodextrin modified plasmonic hydrogel substrate and its use as a surface-enhanced Raman scattering scaffold for antibiotics identification

et al. 2015

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confidence: 99%

Preparation of a native β-cyclodextrin modified plasmonic hydrogel substrate and its use as a surface-enhanced Raman scattering scaffold for antibiotics identification

et al. 2015

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“…The host-guest interaction causes an enthalpy-entropy compensating process in the gas phase whereas the same interaction causes an enthalpy-entropy co-driven process in aqueous solution. That is because inclusion complexation releases a number of water molecules from the cavities of CD [43].…”

Section: Resultsmentioning

confidence: 99%

Docking and physico-chemical properties of α- and β-cyclodextrin complex containing isopulegol: a comparative study

Menezes

Dória

Araújo

et al. 2016

J Incl Phenom Macrocycl Chem

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Isopulegol (ISOP) is a monoterpenoid alcohol presented in the essential oils of several plants that possesses therapeutic properties The aim of this work was prepare samples with ISOP and a-and b-cyclodextrins (aand b-CD) through three different methods: physical mixture, paste method (PC) and slurry complexation (SC). In order to evaluate the formation of inclusion complexes, the techniques of differential scanning calorimetry, thermogravimetry/derivative thermogravimetry, fourier transform infrared spectroscopy, X-ray diffractometry (XRD), gas chromatography-mass spectrometry analyses (GC/ MS), docking, nuclear magnetic resonance and scanning electron microscopy were considered. The analyses of the a-CD or b-CD/ISOP revealed the formation of a complex mainly through the PC and SC methods for a-CD and b-CD, respectively. XRD diffraction characteristics presented formation of a trend to new solid phase, which suggested the formation of inclusion complexes. The GC/MS demonstrated that the PC method was the best one to form complexation with a-CD (48.8 %). Concerning b-CD, the SC method exhibited the strongest complexation (68.3 %). Furthermore, the molecular theoretical docking study demonstrated that a-CD/ISOP inclusion complex formed a more stable complex than did the b-CD/ISOP inclusion complex.

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“…Both sulfa drugs exhibit similar absorption maxima; this is because tautomeric structure is present in both drug molecules [20][21][22][23][24][25]. With an increasing the concentration of SM and SMT, the absorption maximum of both sulfa drugs was completely lost whereas BSA and adenine absorbance was decreased at the same wavelength; i.e., in varying concentration of sulfa drugs, no remarkable spectral shift was noticed in BSA and adenine except a decrease in the intensity.…”

Section: Absorption Spectroscopic Studiesmentioning

confidence: 99%

“…This approach originally developed to illuminate the structure and the excited state behavior of organic molecules and drugs included in cyclodextrin macrocycles through experimental and theoretical [20][21][22][23][24][25][26] explorations. In the view of increasing attention directed toward the importance of investigating interaction between proteins and drugs, we present in this work utilizing UV-visible and fluorescence spectroscopy, cyclic voltammetry and molecular docking studies for investigating the interaction between SM/SMT with BSA/adenine.…”

Section: Introductionmentioning

confidence: 99%

Binding of Sulfamerazine and Sulfamethazine to Bovine Serum Albumin and Nitrogen Purine Base Adenine: A Comparative Study

Rajendiran

Thulasidhasan

2015

ILCPA

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ABSTRACT. Quenching of bovine serum albumin (BSA) and DNA base (adenine) by sulfamerazine (SM) and sulfamethazine (SMT) was studied using UV-visible, fluorescence cyclic voltammetry and molecular docking methods. A strong fluorescence quenching reaction of SM and SMT to BSA/adenine was observed and the quenching mechanism was suggested as static. Both drugs can bind to BSA and adenine with stoichiometric ratio of 1:1 and the protein -drug complexes are stabilized mainly by hydrogen bonds and van der Waals interaction. Compared to SM, SMT contributes substantially higher binding efficiency with BSA/adenine. With addition of drug solution to the adenine/BSA, the oxidation and the reduction peaks shifted towards high and low potentials, respectively. R o , J, r and E values in the BSA-drugs are higher than that of adeninedrug molecules suggest that binding of the sulfa drugs with BSA is higher than adenine -drug molecules. Docking method specify that bioactive site of sulfa drugs moiety, the aniline group is interacted with the BSA molecules.

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Inclusion complex of sulfadimethoxine with cyclodextrins: Preparation and characterization

Cited by 86 publications

References 31 publications

Preparation of a native β-cyclodextrin modified plasmonic hydrogel substrate and its use as a surface-enhanced Raman scattering scaffold for antibiotics identification

Preparation of a native β-cyclodextrin modified plasmonic hydrogel substrate and its use as a surface-enhanced Raman scattering scaffold for antibiotics identification

Docking and physico-chemical properties of α- and β-cyclodextrin complex containing isopulegol: a comparative study

Binding of Sulfamerazine and Sulfamethazine to Bovine Serum Albumin and Nitrogen Purine Base Adenine: A Comparative Study

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