Inclusion complex of methyl-β-cyclodextrin and olanzapine as potential drug delivery system for schizophrenia

Freitas, Márcia Rocha de; Rolim, Larissa Araújo; Soares, Mônica Felts de La Roca; Rolim-Neto, Pedro José; Albuquerque, Manoel Bandeira de; Sobrinho, José Lamartine Soares

doi:10.1016/j.carbpol.2012.03.072

Cited by 82 publications

(59 citation statements)

References 16 publications

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“…Among the mentioned stabilizers, HP-b-CD is an excipient with a relatively high water solubility, low economic cost, and low toxicity, and in the pharmaceutical field, it is usually used to enhance the solubility of insoluble compounds by forming a complex (Tang et al, 2013a). It was recently reported that HP-b-CD reduced the surface tension between dissolution medium and drug (de Freitas et al, 2012;Soares-Sobrinho et al, 2012). Thus, it is a potential surfactant.…”

Section: Introductionmentioning

confidence: 98%

Effects of stabilizing agents on the development of myricetin nanosuspension and its characterization: An in vitro and in vivo evaluation

Hong

Dang

Lin

et al. 2014

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 98%

Effects of stabilizing agents on the development of myricetin nanosuspension and its characterization: An in vitro and in vivo evaluation

Hong

Dang

Lin

et al. 2014

International Journal of Pharmaceutics

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“…The molecular arrangement of these compounds into a truncated cone gives rise to a hydrophobic internal cavity and a hydrophilic outer surface [20,21,22,23,24], which enables the use of this molecule for the formation of inclusion complexes with drugs. As such, the CDs have become the target of numerous studies concerning drug delivery systems [25,26,27,28,29,30,31,32]. For example, Silva et al described a study on the design of novel sensing and biosensing systems based on host-guest complexes [33] via the development of supramolecular structures combining Prussian blue nanoparticles, β-CDs, and layer-by-layer method.…”

Section: Introductionmentioning

confidence: 99%

New Hybrid Nanomaterial Based on Self-Assembly of Cyclodextrins and Cobalt Prussian Blue Analogue Nanocubes

Carvalho

Silva

Macedo

et al. 2015

IJMS

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Supramolecular self-assembly has been demonstrated to be a useful approach to developing new functional nanomaterials. In this work, we used a cobalt Prussian blue analogue (PBA, Co3[Co(CN)6]2) compound and a β-cyclodextrin (CD) macrocycle to develop a novel host-guest PBA-CD nanomaterial. The preparation of the functional magnetic material involved the self-assembly of CD molecules onto a PBA surface by a co-precipitation method. According to transmission electronic microscopy results, PBA-CD exhibited a polydisperse structure composed of 3D nanocubes with a mean edge length of 85 nm, which became shorter after CD incorporation. The supramolecular arrangement and structural, crystalline and thermal properties of the hybrid material were studied in detail by vibrational and electronic spectroscopies and X-ray diffraction. The cyclic voltammogram of the hybrid material in a 0.1 mol·L−1 NaCl supporting electrolyte exhibited a quasi-reversible redox process, attributed to Co2+/Co3+ conversion, with an E1/2 value of 0.46 V (vs. SCE), with higher reversibility observed for the system in the presence of CD. The standard rate constants for PBA and PBA-CD were determined to be 0.07 and 0.13 s−1, respectively, which suggests that the interaction between the nanocubes and CD at the supramolecular level improves electron transfer. We expect that the properties observed for the hybrid material make it a potential candidate for (bio)sensing designs with a desirable capability for drug delivery.

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“…CD are widely used in pharmaceutical, cosmetics, biotechnology, agriculture, textile, chemical, environmental protection industries [15][16][17]. There also exist studies concerning application of CD in active food packaging [18][19][20] and biomedical applications [21][22][23] in the literature. In the food packaging studies, CD were incorporated with polymers in free form to capture undesired molecules in the foods like cholesterol [18], hexanal and cholesterol [19] or in guest molecule-CD-IC form to release an antimicrobial agent (trans-2-hexenal) [20].…”

Section: Introductionmentioning

confidence: 99%

“…In the food packaging studies, CD were incorporated with polymers in free form to capture undesired molecules in the foods like cholesterol [18], hexanal and cholesterol [19] or in guest molecule-CD-IC form to release an antimicrobial agent (trans-2-hexenal) [20]. IC of CD and various types of drugs are prepared and these CD-drug-IC could be used in biomedical applications [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers

Aytaç

Doğan

Tekinay

et al. 2014

Colloids and Surfaces B: Biointerfaces

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a b s t r a c tAllyl isothiocyanate (AITC) is known as an efficient antibacterial agent but it has a very high volatility. Herein, AITC and AITC/␤-cyclodextrin (CD)-inclusion complex (IC) incorporated in polyvinyl alcohol (PVA) nanofibers were produced via electrospinning. SEM images elucidated that incorporation of AITC and AITC/␤-CD-IC into polymer matrix did not affect the bead-free fiber morphology of PVA nanofibers. 1 H-NMR and headspace GC-MS analyses revealed that very low amount of AITC was remained in PVA/AITC-NF because of the rapid evaporation of AITC during the electrospinning process. Nevertheless, much higher amount of AITC was preserved in the PVA/AITC/␤-CD-IC-NF due to the CD inclusion complexation. The sustained release of AITC from nanofibers was evaluated at 30 • C, 50 • C and 75 • C via headspace GC-MS. When compared to PVA/AITC-NF, PVA/AITC/␤-CD-IC-NF has shown higher antibacterial activity against Escherichia coli and Staphylococcus aureus due to the presence of higher amount of AITC in this sample which was preserved by CD-IC.

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Inclusion complex of methyl-β-cyclodextrin and olanzapine as potential drug delivery system for schizophrenia

Cited by 82 publications

References 16 publications

Effects of stabilizing agents on the development of myricetin nanosuspension and its characterization: An in vitro and in vivo evaluation

Effects of stabilizing agents on the development of myricetin nanosuspension and its characterization: An in vitro and in vivo evaluation

New Hybrid Nanomaterial Based on Self-Assembly of Cyclodextrins and Cobalt Prussian Blue Analogue Nanocubes

Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers

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