Inclusion complex of antiasthmatic compound with 2-hydroxypropyl-β-cyclodextrin: Preparation and physicochemical properties

Host-guest inclusion complex of desloratadine with 2-(hydroxy)propyl-?-cyclodextrin (HP-?-CD): Preparation, binding behaviors and dissolution properties

“…The absorption peak of DSL at 165.18°C disappeared in the inclusion complex thermograms (Figure 4c-e). Complete absence of the melting endotherm of the active agent implies amorphization of the crystalline substance in the presence of an amorphous structure and verifies constitution of inclusion complex [7,9,11].…”

“…DSC is an important analytical technique for the analysis of solid materials as it can supply exhaustive information on their physical and energy characteristics [32]. DSC is therefore commonly utilized to investigate the interactions between drug substances and CDs in solid form [11]. We can elicit about solidstate modifications and interactions between the components and verify complexation mechanism by comparison with the thermograms of individual constituents, their physical blend and the prepared inclusion complexes.…”

“…The thermogram of HP-β-CD demonstrated two broad endotherms; one, appeared around 80°C, which can be related to the release from the CD cavity of crystallized water molecules [12], and the other wide endothermic peak at 280°C owing to the thermal degradation [21] (Figure 4b). The physical mixture revealed a simple superposition of pure DSL and HP-β-CD endothermic peaks, thereby indicating that the host and guest molecules do not interact in physical mixture [11] (Figure 4c). The absorption peak of DSL at 165.18°C disappeared in the inclusion complex thermograms (Figure 4c-e).…”

“…The FT-IR of HP-β-CD includes wide band at 3343 cm -1 that ascribed to H-bond stretching vibrations of hydroxyl groups. The other bands are organized as follows: 2910 cm -1 (C-H) stretching vibrations of O-H bonds in C-O-H groups and water molecules; 1362 and 1149 cm -1 (C-H, deformation vibrations in groups of CH2OH and CHOH); and adsorption peak at 1080 cm -1 (C-O-C) [11,19]. FT-IR spectrum of the physical mixture ( Figure 5c) is a combination of HP-β-CD and DSL's spectra.…”

<p>Enhancement of Simvastatin ex vivo Permeation from Mucoadhesive Buccal Films Loaded with Dual Drug Release Carriers</p>

“…Differential scanning calorimetry (DSC) is a validated tool for studying the thermodynamic changes and the interactions that occur between tested components. 54 The DSC thermographs of pure SMV, HP β-CD, their physical mixture and the freeze-dried inclusion complex are illustrated in Figure 3. The thermogram of pure SMV revealed a sharp endothermic peak at 141.35°C indicating the crystallinity of the drug, while the thermogram of HP β-CD showed a short broad endothermic peak between 50°C and 110°C.…”