“…Findlay (5) reports the presence of cytoplasmic inclusion bodies in polymorphonuclear leucocytes, eosinophiles and large mononuclear cells of the blood of sheep infected with tick-borne fever. These may be resolved into particles resembling elementary bodies.…”
Section: Effects On the Leucocytes And Leucopoietic Tissuesmentioning
In a recent report (1) we described a highly fatal epizootic disease of cats which, we demonstrated, is caused by a filterable agent. The usual clinical course is characterized by a fulminating leucopenia associated with 1 or 2 days of manifest illness during which vomiting, moderate elevation of temperature and progressive anorexia and weakness are almost constant features. A large series of autopsies with tissue sections showed the constant, outstanding pathological changes restricted to the bone marrow, lymphoid tissues and intestines. In these affected organs eosinophilic intranuclear inclusion bodies were found to be a characteristic feature. We have more recently, through the observation and autopsy of approximately 50 more kittens suffering from this infection, noted several pathological changes, not previously described, related to the blood and the hematopoietic tissues. The description of these which forms the matter of this report is of value, we believe, in the interpretation of the causes underlying the observed quantitative abnormalities of the cellular elements of the blood.
“…Findlay (5) reports the presence of cytoplasmic inclusion bodies in polymorphonuclear leucocytes, eosinophiles and large mononuclear cells of the blood of sheep infected with tick-borne fever. These may be resolved into particles resembling elementary bodies.…”
Section: Effects On the Leucocytes And Leucopoietic Tissuesmentioning
In a recent report (1) we described a highly fatal epizootic disease of cats which, we demonstrated, is caused by a filterable agent. The usual clinical course is characterized by a fulminating leucopenia associated with 1 or 2 days of manifest illness during which vomiting, moderate elevation of temperature and progressive anorexia and weakness are almost constant features. A large series of autopsies with tissue sections showed the constant, outstanding pathological changes restricted to the bone marrow, lymphoid tissues and intestines. In these affected organs eosinophilic intranuclear inclusion bodies were found to be a characteristic feature. We have more recently, through the observation and autopsy of approximately 50 more kittens suffering from this infection, noted several pathological changes, not previously described, related to the blood and the hematopoietic tissues. The description of these which forms the matter of this report is of value, we believe, in the interpretation of the causes underlying the observed quantitative abnormalities of the cellular elements of the blood.
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