Including copper sulphate or dicopper oxide in the diet of broiler chickens affects performance and copper content in the liver

Hamdi, Manel; Solà, David; Franco, Róbson Maia; Durosoy, S.; Romeo, Andrea; Pérez, J. F.

doi:10.1016/j.anifeedsci.2018.01.014

Cited by 25 publications

(22 citation statements)

References 31 publications

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“…Plasma triglyceride concentration of the quail chicks fed Cu-supplemented diets were significantly (p<0.05) decreased as supplemental level of Cu increased (Tables 6 and 7). This result is consistent with those observed in pigs Bowland 1968 andAmer andElliot 1973), egglaying hens (Pearce et al 1983), and in broiler chicks (Bakalli et al 1995;Hamdi et al 2018). Triglycerides-lowering effect of Cu supplementation could be through its reducing impact on the activity of fatty acid synthetase (FAS) which in turn resulted in a reduction in fatty acid synthesis from Acetyl COA and finally decreasing triglycerides biosynthesis.…”

Section: Blood Biochemical Responsessupporting

confidence: 89%

“…In another study, however, Cu-Met was found to exert a linear increase in serum cholesterol level, accompanied by a significant decrease in triglycerides level (Chowdhury et al 2004). It was also observed that supplementation of high Cu levels resulted in high excretion rate of Cu through feces (Paik et al 1999;Hamdi et al 2018). Jenkins et al (1970) have reported a 5% increase in growth response when Cu (250 mg/kg) was added to wheat-fish meal diet, but growth rate was depressed when the same level was added to a corn-soybean diet.…”

Section: Introductionmentioning

confidence: 95%

“…Copper (Cu) was reported by many workers as an essential trace element required for survival of all organisms from bacterial cells to human (Linder 1991;Hamdi et al 2018). Copper is involved in multiple extracellular and intracellular enzymes such as super-oxide dismutase, ceruloplasmin, cytochrome oxidase and lysyl oxidase (Klasing 1998;Wieleba and Pasternak 2001) Moreover, copper was nearly observed as a constituent element in all body cells, being particularly concentrated in the liver, which acts as the main copper storage organ of the body (Zhau, et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Physiological and Antioxidant Responses of Japanese Quail to Dietary Copper Supplementation

Ali

2018

Journal of Animal and Poultry Production

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Two experiments were conducted to elucidate the effect of dietary copper supplementation on performance, physiological, hematological and antioxidant responses of day-old unsexed Japanese quail chicks (Coturnix coturnix Japonica). In each experiment, a total number of 250 quails were summited to five experimental treatments (50 chicks in five replicates each. The first one (control) was fed the basal diet while the other groups were fed the same diet supplemented with copper as cupric sulfate pentahydrate at levels of 50, 100, 150 and 200 mg/kg diet. In experiment 1 (Exp.1), chicks were fed the Cu-supplemented diets until 6 weeks of age whereas the supplementation period in experiment 2 (Exp.2) was for the first five weeks of age followed by a final period of one week during which birds fed the control basal diet. Results demonstrated that supplementation of copper sulfate to diets either or 6 (Exp. 1) or 5 weeks (Exp. 2) had significantly improved live body weight, weight gain, feed conversion ratio and low mortality rate of quail chicks. Hematological indices in terms of RBCs count, hemoglobin concentration, hematocrit, mean corpuscular volume, WBCs count and H /L ratio were significantly improves in quails fed Cu-supplemented diets up to 100 mg/Kg in Exp.1 and up to 150 mg/Kg in Exp. 2. Birds fed Cu-supplemented diets for six weeks (Exp. 1) up to 100mg/Kg had significantly higher plasma total protein, globulin, Immunoglobulins (Y , M , A) and high density lipoprotein (HDL) but lower plasma total cholesterol, triglycerides and low density lipoprotein (LDL) than the control ones. A similar trend was recorded for Exp. 2 quails, but plasma protein fractions were not significantly affected. In both experiments, blood reduced glutathione (GSH), superoxide dismutase (SOD) activity and total antioxidant capacity (TAC) were significantly increased with Cu-supplemented diets, while malondialdehyde (MDA) was significantly decreased in the experimental groups compared with the control. The obtained results indicate that dietary supplementation with cupric sulfate pentahydrate at levels up to 100 mg/kg could improve growth performance, antioxidant defense system, immunity and lower cholesterol content of growing Japanese quail.

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Section: Blood Biochemical Responsessupporting

confidence: 89%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Physiological and Antioxidant Responses of Japanese Quail to Dietary Copper Supplementation

Ali

2018

Journal of Animal and Poultry Production

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“…It has been reported that pharmacological levels of Cu may compromise dietary phosphorus bioavailability for broilers by forming an insoluble complex of phytate-Cu ( Banks et al., 2004 ). However, the tibia Ca and P content measured in this study indicates that the basal diet may contain enough nonphytate phosphorus to sustain normal bone development and to neutralize the antagonistic effects of the high level of Cu on dietary phosphorus absorption ( Hamdi et al., 2018 ). In addition, the tibia from birds fed the diet containing CH had higher Cu content in comparison with that from birds fed the NC diet but did not differ from those fed CuSO 4 on day 14, suggesting a similar assimilability of Cu into the bones from these 2 sources when fed at a recommended nutrition dosage for broilers (15 mg/kg; Aviagen, 2014 ).…”

Section: Discussionmentioning

confidence: 85%

Copper hydroxychloride is more efficacious than copper sulfate in improving broiler chicken's growth performance, both at nutritional and growth-promoting levels

et al. 2020

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This study was designed to compare the effects of nutritional and growth-promoting levels of copper hydroxychloride ( CH ) with copper sulfate ( CuSO 4 ) on growth, carcass characteristics, tibia traits and mineral concentration in broilers fed a conventional wheat-soybean meal–based diet. Day-old Ross 308 male chicks ( n = 864) were randomly assigned into 8 dietary treatments with 6 replicates of 18 chicks per treatment. The dietary treatments included a basal diet containing no supplemental copper ( Cu ) serving as the negative control ( NC ); basal diet supplemented with 15 or 200 mg/kg Cu as CuSO 4 ; basal diet supplemented with either 15, 50, 100, 150, or 200 mg/kg Cu from CH. Diets were fed over the starter (day 1–14) and grower (day 14–35) phases. Birds in the NC group gained the same body weight and had similar feed conversion ratio ( FCR ) to birds receiving 15 mg/kg Cu as CuSO 4 , but birds receiving 15 mg/kg Cu as CH had a lower FCR than the NC birds (day 0–35; P < 0.05). Birds fed 200 mg/kg Cu as CH gained more weight (77 g/bird) and had a lower FCR (3.2 point) compared with those fed 200 mg/kg Cu as CuSO 4 ( P < 0.01). Based on broken-line regression models, the optimum inclusion level of Cu as CH in the diet for optimal body weight gain and FCR were estimated to be 109.5 and 72.3 mg/kg, respectively ( P < 0.001). Carcass characteristics were not affected by dietary Cu sources or levels ( P > 0.05). The highest and lowest tibia ash content were observed in birds fed diet with 150 mg/kg Cu as CH and 200 mg/kg Cu as CuSO 4 , respectively ( P < 0.05). Supplementation with 200 mg/kg Cu as CH resulted in higher duodenal mucosa Cu content compared with the diet containing 200 mg/kg Cu as CuSO 4 ( P < 0.001). In conclusion, supplementation of Cu from CH was more efficacious than CuSO 4 in promoting growth performance, both at nutritional and pharmacological levels.

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“…Cu sulfate pentahydrate is a widely used source in pig diets. It is characterized by a high solubility in water and acid solutions and hence higher interactions with other components of the diet, including phytic acid and other minerals [ 15 , 16 , 17 ]. Phytic acid derived from plant ingredients can easily bind divalent metal ions such as Cu, resulting in mineral–phytin complexes and reducing the solubility of Cu and P [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Preference of Newly Weaned Pigs and Nutrient Interactions According to Copper Levels and Sources with Different Solubility Characteristics

Villagómez-Estrada

Pérez

Kuijk³

et al. 2020

Animals

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Two feeding preference experiments and an in vitro assay were performed to assess the weaned pig preference for Cu doses and sources based on their sensorial perception and on the likely post-ingestive effects of Cu. At day 7 post-weaning, a total of 828 pigs were distributed into two different experiments. In Exp.1 (dose preference) a diet with a nutritional Cu level (15 mg/kg) of Cu sulfate (SF) was pair offered with higher Cu levels (150 mg/kg) of either SF or hydroxychloride (HCl). In Exp.2 (source preference), a diet supplemented with Cu-SF at 150 mg/kg was compared to a Cu-HCl (150 mg/kg) diet. At the short-term (day 7–9) and for the entire experimental week (day 7–14), pigs preferred diets with a high Cu level than with Cu at a nutritional dose (p < 0.05). Likewise, pigs preferred diets supplemented with a Cu-HCl source compared to diets with Cu-SF (p < 0.05). In vitro assay results showed a greater solubility and interaction of Cu-SF with phytic acid compared to Cu-HCl. In conclusion, pigs chose diets with higher levels of Cu probably to re-establish homeostasis after weaning. Pigs preferred diets with Cu-HCl compared to Cu-SF probably due to their solubilities and chemical differences.

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Including copper sulphate or dicopper oxide in the diet of broiler chickens affects performance and copper content in the liver

Cited by 25 publications

References 31 publications

Physiological and Antioxidant Responses of Japanese Quail to Dietary Copper Supplementation

Physiological and Antioxidant Responses of Japanese Quail to Dietary Copper Supplementation

Copper hydroxychloride is more efficacious than copper sulfate in improving broiler chicken's growth performance, both at nutritional and growth-promoting levels

Dietary Preference of Newly Weaned Pigs and Nutrient Interactions According to Copper Levels and Sources with Different Solubility Characteristics

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