Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity

Wagner, Alixandra; White, A.; Tang, Man Chio; Agarwal, Sushant; Stueckle, Todd A.; Rojanasakul, Yon; Gupta, Rakesh; Dinu, Cerasela Zoica

doi:10.1038/s41598-018-28884-y

Cited by 20 publications

(15 citation statements)

References 135 publications

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“…In vitro models employing both acute and sub-chronic exposure conditions have been developed and used to predict in vivo toxicological responses ( Cho et al, 2013 ; Manke et al, 2014 ; Wang et al, 2014 ). Based on comparable exposure doses, time courses, target cell types, and relevant biological endpoints, consistent results have been obtained from comparable experiments with in vitro vs. in vivo models using similar ENMs (e.g., based on physicochemical properties) such as carbon nanotubes ( Mercer et al, 2011 ; Mishra et al, 2012 ; Sargent et al, 2014 ; Siegrist et al, 2014 ; Snyder-Talkington et al, 2015 , 2019 ), metal oxide nanoparticles ( Ma et al, 2015 ; Davidson et al, 2016 ), boron nitride nanotubes ( Kodali et al, 2017 ; Xin et al, 2020 ), and end-life cycle (incinerated) nanoclay enabled thermoplastics ( Stueckle et al, 2018 ; Wagner et al, 2018 ). These results, mainly observed from CDC/NIOSH research projects on the ENMs of agency interest listed in Table 1 , support the implementation of in vitro models as a rapid and economical tool to screen and predict the potential in vivo toxicological responses to ENMs for reducing, refining, and replacing animal usage.…”

Section: Agency Needs For Enm Testingsupporting

confidence: 65%

U.S. Federal Agency interests and key considerations for new approach methodologies for nanomaterials

Petersen

Ceger

Allen

et al. 2021

ALTEX

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of such State, or (B) which affects trade, traffic, transportation, or commerce described in clause (A).(4) The terms "distribute in commerce" and "distribution in commerce"' when used to describe an action taken with respect to a chemical substance or mixture or article containing a substance or mixture mean to sell, or the sale of, the substance, mixture, or article in commerce ; to introduce or deliver for introduction into commerce, or the introduction or delivery for intr-oduction into commerce of, the substance, mixture, or article; or to hold, or the holding of, the substance, mixture, or article after its introduction into commerce.(5) The term "environment" includes water, air, and land and the i interrelationship which exists among and between water, air, and land and all living things.(6) The term "health and safety study" means any study of any effect of a chemical substance or mixture on health or the environment or on both, including underlying data and epidemiological studies, studies of occupational exposure to a chemical substance or mixture, toxicological, clinical, and ecological studies of a chemical substance or mixture, and any test performed pursuant to this Act.(7) The term "manufacture" means to import into the customs territory of the United States (as defined in general headnote 2 of the Tariff Schedules of the United States), produce, or manufacture. 19 USC 1202.(8) The term "mixture" means any combination of two or more chemical substances if the combination does not occur in nature and is not, in whole or in part, the result of a chemical reaction; except that such term does include any combination which occurs, in whole or in part, as a result of a chemical reaction if none of the chemical substances comprising the combination is a new chemical substance and if tlie combination could have been manufactured for commercial purposes without a chemical reaction at the time the chemical substances comprising the combination were combined.(9) The term "new chemical substance" means any chemical substance which is not included in the chemical substance list compiled and published under section 8 (b).Post, p. 2027. (10) The term "process" means the preparation of a chemical substance or mixture, after its manufacture, for distribution in commerce-(A) in the same form or physical state as, or in a different form or physical state from, that in which it was received by the person so preparing such substance or mixture, or (B) as part of an article containing the chemical substance .;;:;>• or mixture. (11) The term "processor" means any person who processes a chemical substance or mixture.(12) The term "standards for the development of test data" means a prescription of-(A) the-(i) health and environmental effects, and (ii) information relating to toxicity, persistence, and other characteristics which affect health and the environment, for which test data for a chemical substance or mixture are to be developed and any analysis that is to be performed on such data, and -(B) to the extent necess...

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Section: Agency Needs For Enm Testingsupporting

confidence: 65%

U.S. Federal Agency interests and key considerations for new approach methodologies for nanomaterials

Petersen

Ceger

Allen

et al. 2021

ALTEX

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“…In vitro studies have shown that nanoclays exposure (e.g. montmorillonite) decreases cell viability and induces changes in morphology and cell-cell interactions in human lung epithelial cells(Wagner et al, 2017a;Wagner et al, 2017b;Wagner et al, 2018). Stueckle et al also evaluated the effects of pre-and post-incinerated forms of uncoated and organomodified nanoclays in mice and observed that pulmonary inflammation and toxicity relies on coating presence and incineration status.…”

mentioning

confidence: 99%

Nanoparticle exposure and hazard in the ceramic industry: an overview of potential sources, toxicity and health effects

Bessa

Brandão

Viana

et al. 2020

Environmental Research

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The ceramic industry is an industrial sector of great impact in the global economy that has been benefitting from advances in materials and processing technologies. Ceramic manufacturing has a strong potential for airborne particle formation and emission, namely of ultrafine particles (UFP) and nanoparticles (NP), meaning that workers of those industries are risk of potential exposure to these particles. At present, little is known on the impact of engineered nanoparticles (ENP) on the environment and human health and no established Occupational Exposure Limits (OEL) or specific regulations to airborne nanoparticles (ANP) exposure exist raising concerns about the possible consequences of such exposure. In this paper, we provide an overview of the current knowledge on occupational exposure to NP in the ceramic industry and their impact on human health. Possible sources and exposure scenarios, a summary of the existing methods for evaluation and monitoring of ANP in the workplace environment and proposed Nano Reference Values (NRV) for different classes of NP are presented. Case studies on occupational exposure to ANP generated at different stages of the ceramic manufacturing process are described. Finally, the toxicological potential of intentional and unintentional ANP that have been identified in the ceramic industry workplace environment is discussed based on the existing evidence from in vitro and in vivo inhalation toxicity studies.

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“…When clays are introduced into polymer materials, it can result to spontaneous exposure to them and it requires assessing migration of both microparticles and nano-structured clays from packing materials into food products [41]. Besides, NCs can penetrate the environment in considerable quantities during a product life cycle, for example, when wasted packaging and packing materials are incinerated at combustion plants [110]. Food additives and medications are other significant sources of oral exposure to clays in developed countries [111,112].…”

Section: Data Obtained Via Experiments In Vitromentioning

confidence: 99%

Nanoclays in food products: benefits and possible risks (literature review)

Gmoshinski¹,

Bagryantseva²,

Arnautov³

et al. 2020

Health Risk Analysis

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Nanoclays (NC) are aluminosilicates that consist of layers (nano-plates) being 1-2 nanometers thick and having a diameter over 1 µm, nanotubes, and nano-disks. Due to such structure and their ion-exchange and sorption properties as well as gas permeability NC are widely used in industries, agriculture, and medicine. Gas-barrier composite packages are made from hydrophobic NC modified with cation-active surface-active substances. A person can be orally exposed to NC due to their migration from packages into food products and drinks, when NC are applied in medicine as enteric sorbents and antibacterial preparations, they can be introduced with food additives and residual quantities of technological auxiliaries as well as in case when food products and agricultural raw materials are accidentally contaminated with clays. Multiple research works dwell on experiments with NC performed with model systems in vitro when NC turned out to be cytotoxic for various cell types, and it was more apparent for hydrophobic NC than for their non-modified analogues. Minimum effective NC dose varied from 0.001 to 1 mg/ml in various in vitro tests. In vitro research on NC toxicity yielded somewhat contradictory results. Though NC didn't seem to have apparent acute toxicity (IV hazard category, LD 50 > 5,000 mg/kg), results obtained via sub-acute and chronic experiments with their duration being up to 196 days and single clinical observations revealed a number of both toxic and non-toxic effects. Organic NC modifiers were highly toxic in vitro. Besides, NC produce anti-microbe effects and it may result in dysbiotic disorders when they are introduced orally. Model experiments revealed that NC and their organic modifiers could possibly migrate from packages into food products. NC are able to free silicon and aluminum that are partly biologically available. A contribution made by NC that are contained in packages into overall exposure to toxic aluminum should be examined profoundly given an adverse situation caused by clay minerals being introduced into a human body as components contained in food additives. Assessment of aluminum consumption with food rations in Russia and several foreign countries revealed it was necessary to exclude potassium and calcium aluminosilicates, bentonite, and kaolin (Е555, Е556, Е558, and Е559) from the list of additives that are permitted for use in food industry.

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Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity

Cited by 20 publications

References 135 publications

U.S. Federal Agency interests and key considerations for new approach methodologies for nanomaterials

U.S. Federal Agency interests and key considerations for new approach methodologies for nanomaterials

Nanoparticle exposure and hazard in the ceramic industry: an overview of potential sources, toxicity and health effects

Nanoclays in food products: benefits and possible risks (literature review)

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