Incidentally discovered splenic vascular lesion Part 1

Musgrave, Nicholas; Williamson, Richard; O’Rourke, Nicholas; Searle, Jeffrey

doi:10.1080/0031302021000035983

Cited by 11 publications

(8 citation statements)

References 10 publications

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“…Gross pathology of LCA is characterized by single, or more commonly, multiple pigmented focal nodules well-delineated from normal spleen parenchyma [ 28 , 30 ]. The colour of these nodules may be dark red, brown, or black, consistent with blood or blood products of varying chronicity [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

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Incidental littoral cell angioma of the spleen

et al. 2008

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Section: Discussionmentioning

confidence: 99%

“…The colour of these nodules may be dark red, brown, or black, consistent with blood or blood products of varying chronicity [ 28 ]. Rarely, LCA appears white on gross pathology [ 1 , 30 ]. The size of these lesions varies and may range from 0.1 cm to 11 cm in diameter [ 1 , 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Incidental littoral cell angioma of the spleen

et al. 2008

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“…At present, the final diagnosis is only possible via histopathological examination [5,6,[12][13][14]. The lesions may be solitary or multiple, and are composed of vascular channels lined by cells that share the morphological and immunohistochemical findings characteristic for both the endothelial and histiocytic cells…”

Section: Discussionmentioning

confidence: 99%

Is littoral cell angioma of the spleen as rare as previously believed in the pediatric population?

Matuszczak¹,

Reszeć²,

Dębek³

et al. 2012

Folia Histochem Cytobiol.

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Littoral cell angioma (LCA) is a rare primary splenic vascular tumor, originating from the littoral cells lining the red pulp sinuses of the spleen. There are only a handful of case reports of LCA in children to be found in the literature. We performed a retrospective analysis of the medical charts of pediatric patients with splenic lesions who were treated between 2005 and 2010 in the Pediatric Surgery Department of the Medical University of Bialystok. Surprisingly, LCA accounted for 37.5% of the splenic lesions found in our series. The majority of LCA tumors are benign, but given their malignant potential, splenectomy and long-term follow-up should be the gold standard for their management. We strongly support the use of further cross-sectional studies to properly elucidate the prevalence of littoral cell angioma of the spleen in the pediatric population. (Folia Histochemica et Cytobiologica 2012, Vol. 50, No. 3, 480-485)

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“…These vascular tumors range in size from 0.1 to 9 cm [7]. The CT findings are nonspecific for single or more often multiple, diffuse low-attenuation nodular masses [2,6,8].…”

Section: Discussionmentioning

confidence: 97%

“…Because they can mimic other vascular tumors such as hemangiomas or hamartomas, splenectomy is often the only method of definitive diagnosis. Immunohistochemical staining is positive for CD31, CD21 [1,6], von Willebrand factor, CD68 [6,7], and occasionally positive CD34 [9] and CD8 [7]. In about one third of cases, benign littoral cell angioma has been associated with other visceral malignancies, especially colorectal adenocarcinoma; therefore, postoperative monitoring has been advocated [6,7,10,11].…”

Section: Discussionmentioning

confidence: 99%