Incidentally discovered low‐grade appendiceal mucinous neoplasm: a precursor to pseudomyxoma peritonei

Padmanaban, Vennila; Morano, William F.; Gleeson, Elizabeth M.; Aggarwal, Aruna; Mapow, Beth; Stein, David E.; Bowne, Wilbur B.

doi:10.1002/ccr3.694

Cited by 52 publications

(59 citation statements)

References 24 publications

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“…According to the 8th edition of the American Joint Committee on Cancer (AJCC) Staging Manual, mucinous adenocarcinomas of the appendix are classified into low-grade and high-grade (well-differentiated and moderately/poorly differentiated, respectively) tumor based on histological grade in the AJCC TNM Staging System [5][6][7]. Due to the low incidence, lacking of available data about the prognostic factors for appendix mucinous adenocarcinomas and non-adenocarcinomas in current clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Management and prognostic prediction of appendiceal mucinous adenocarcinoma with peritoneal metastasis: a single center study in China

Wang

Zhai

et al. 2020

BMC Cancer

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Background: To investigate the clinical and pathological characteristics of appendiceal mucinous adenocarcinoma with peritoneal metastasis and analyze the prognostic factors. Methods: A retrospective analyses of clinicopathological features of 50 patients with appendiceal mucinous adenocarcinoma with peritoneal metastasis from January, 2013 to December, 2017 in Aerospace Central Hospital, Beijing, China. Survival data calculation and comparison were respectively performed with the Kaplan-Meier method and the log-rank test. The Cox proportional hazards regression method was used for multivariate survival analyses. Results: Cytoreduction for appendiceal mucinous adenocarcinoma was conducted on 50 patients (24 males and 26 females), with a median age of 52.5 years at the time of surgery (range 31-71 years). The median overall survival (OS) time was 24 months, with 2-,3-and 5-year survival rates of 53, 24 and 8%, respectively. At the last follow-up in December 2018, 13 patients were still alive. Multivariate analysis revealed that patients who had low Ki-67 expression (less than 50%) and CCR (completeness of cytoreduction) 0/1/2 score had significantly better OS rate than their respective counterparts. Conclusions: Ki-67 expression statue and CCR score could be employed as the prognosis prediction in patients with appendiceal mucinous adenocarcinoma.

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Section: Introductionmentioning

confidence: 99%

Management and prognostic prediction of appendiceal mucinous adenocarcinoma with peritoneal metastasis: a single center study in China

Wang

Zhai

et al. 2020

BMC Cancer

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“…According to the 8 th edition of the American Joint Committee on Cancer (AJCC) Staging Manual, mucinous adenocarcinomas of the appendix are classified into low-grade and high-grade (welldifferentiated and moderately/poorly differentiated, respectively) tumor based on histological grade in the AJCC TNM Staging System [5][6][7]. Due to the low incidence, lacking of available data about the prognostic factors for appendix mucinous adenocarcinomas and non-adenocarcinomas in current clinical practice.…”

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confidence: 99%

Management and Prognostic Prediction of appendiceal mucinous adenocarcinoma with peritoneal metastasis: a single center study in China

Wang

Zhai

et al. 2019

Preprint

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Background To investigate the clinical and pathological characteristics of appendiceal mucinous adenocarcinoma with peritoneal metastasis and analyze the prognostic factors.Methods A retrospective analyses of clinicopathological features of 50 patients with appendiceal mucinous adenocarcinoma with peritoneal metastasis from January, 2013 to December, 2017 in Aerospace Central Hospital, Beijing, China. Survival data calculation and comparison were respectively performed with the Kaplan-Meier method and the log-rank test. The Cox proportional hazards regression method was used for multivariate survival analyses.Results Cytoreduction for appendiceal mucinous adenocarcinoma was conducted on 50 patients (24 males and 26 females), with a median age of 52.5 years at the time of surgery (range 31-71 years). The median overall survival (OS) time was 24 months, with 2-,3- and 5-year survival rates of 53%, 24% and 8%, respectively. At the last follow-up in December 2018, 13 patients were still alive. Multivariate analysis revealed that patients who had low Ki-67 expression (less than 50%) and CCR (completeness of cytoreduction) 0/1/2 score had significantly better OS rate than their respective counterparts.Conclusions Ki-67 expression statue and CCR score could be employed as the prognosis prediction in patients with appendiceal mucinous adenocarcinoma.

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“…The goal of management of LAMN includes the prevention of rupture, seeding, and development of pseudomyxoma peritonei (PMP) [ 27 ]. Low-grade appendiceal mucinous neoplasms with acellular or cellular mucin in the right lower quadrant are at low and high risk, respectively, for dissemination in the peritoneal cavity.…”

Section: Discussionmentioning

confidence: 99%

A Unique Case of Low-Grade Mucinous Neoplasm in Stump Appendectomy

Al‐Tarakji

Ali

Shah

et al. 2020

Case Reports in Surgery

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Background. We describe a case of a young male with a history of appendectomy one year ago, who developed symptoms of stump appendicitis, and after removing this stump, histopathology showed low grade neoplasm. Summary. Stump appendicitis is an uncommon complication after appendectomy and may lead to serious complications. Management of low-grade appendiceal mucinous neoplasm (LAMN) is controversial, and we discuss the importance of the case. Conclusion. The case of young male post stump appendectomy with histopathology showing LAMN in the stump of the appendix, which to our knowledge, is the first in the medical literature and, discuss the stump appendicitis and incomplete appendectomy concerning malignancy, mucinous neoplasm, and adenocarcinoma.

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Incidentally discovered low‐grade appendiceal mucinous neoplasm: a precursor to pseudomyxoma peritonei

Cited by 52 publications

References 24 publications

Management and prognostic prediction of appendiceal mucinous adenocarcinoma with peritoneal metastasis: a single center study in China

Management and prognostic prediction of appendiceal mucinous adenocarcinoma with peritoneal metastasis: a single center study in China

Management and Prognostic Prediction of appendiceal mucinous adenocarcinoma with peritoneal metastasis: a single center study in China

A Unique Case of Low-Grade Mucinous Neoplasm in Stump Appendectomy

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