Incidentally detected right-to-left intracardiac shunt with Eisenmenger syndrome on V/Q SPECT/CT

Güngör, Serkan; Aras, Mustafa; Novruzov, Fuad; Sünbül, Murat; Dede, Fuat

doi:10.1016/j.remn.2014.09.003

Cited by 1 publication

(1 citation statement)

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“…The main limitation of our study is the sample size, mostly affecting the subgroup of Non-AD patients. Also, our sample did not include patients with other forms of cognitive impairment at baseline diagnosis, like non-amnestic MCI, vascular dementia, atypical parkinsonism or Parkinson's dementia, in which 18 F-FDG or amyloid PET have proved useful for clinical characterization ( 45 , 46 ). Another limitation is the lack of availability of tau biomarkers that are currently under development in our center.…”

Section: Discussionmentioning

confidence: 99%

Clinical Impact of PET With 18F-FDG and 11C-PIB in Patients With Dementia in a Developing Country

et al. 2021

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Introduction: The objective of this study was to evaluate the clinical impact PET with 18F-FDG and 11C-PIB in patients with dementia in a developing country.Methodology: Retrospective study of the patients referred for the evaluation of dementia to the only PET center in Uruguay. A total of 248 patients were identified, from which 70 patients were included based on the availability of medical history and clinical follow-up. Main outcomes included change in diagnosis, diagnostic dilemma and AD treatment. We evaluated the association of clinical outcomes with PET concordance with baseline diagnosis, diagnostic dilemma, level of education, AD pathology/Non-AD pathology (AD/Non-AD), baseline diagnosis and 11C-PIB PET result.Results: Baseline clinical diagnosis was concordant with 18F-FDG and 11C-PIB PET results in 64.7 and 77.1% of the patients, respectively. Change in diagnosis after PET was identified in 30.0% of the patients and was associated with discordant 18F-FDG (p = 0.002) and 11C-PIB (p < 0.001) PET results, previous diagnostic dilemma (p = 0.005), low education (p = 0.027), Non-AD baseline diagnosis (p = 0.027), and negative 11C-PIB PET result (p < 0.001). Only the last variable remained significant in the multivariate analysis (adjusted p = 0.038). Diagnostic dilemma decreased after PET from 15.7 to 7.1% (p = 0.11) and was associated with Non-AD diagnosis (p = 0.002) and negative 11C-PIB PET result (p = 0.003). Change in AD treatment after PET occurred in 45.7% of the patients.Conclusion:18F-FDG and 11C-PIB PET had a significant clinical impact in terms of change in diagnosis and treatment in patients with dementia in a developing country, similar to that reported in high-income countries.

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Section: Discussionmentioning

confidence: 99%