Incidental Unruptured Intracranial Aneurysms Do Not Impact Outcome in Patients With Acute Cerebral Infarction

Abstract

Background: This study was to examine the patients with acute cerebral infarction (ACI) treated at a single center over 9 years and who underwent Unruptured intracranial aneurysm (UIA) screening by three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA), and to explore the factors associated with outcomes.Methods: The outcome was the modified Rankin scale (mRS) score at 90 days after stroke onset. The outcome was classified into a good outcome (mRS score of 0–2 points) and poor outcome (mRS score of 3–6 points).Results: UIAs were found in 260 (6.5%) of 4,033 patients with ACI; 2,543 (63.1%) had a good outcome, and 1,490 (36.9%) had a poor outcome. There was no difference in outcomes between the two groups (P = 0.785). The multivariable analysis showed that age (OR = 1.009, 95%CI: 1.003–1.014, P = 0.003), diabetes (OR = 1.179, 95%CI: 1.035–1.342, P = 0.013), ischemic stroke history (OR = 1.451, 95%CI: 1.256–1.677, P < 0.001), and baseline NIHSS score (OR = 1.034, 95%CI: 1.018–1.050, P < 0.001) were independently associated with the 90-day outcomes in patients with ACI. The presence of incidental UIA was not associated with outcomes after ACI.Conclusions: Age, diabetes, ischemic stroke history, and baseline NIHSS score were independently associated with the early outcomes of patients with ACI.

Risk factors and a prediction model for unruptured intracranial aneurysms in patients with ischemic stroke using carotid intima-media thickness and systemic atherosclerosis

“…Several studies have reported incidental intracranial aneurysms in patients ( 17 – 19 ). Oh et al collected data from 314 patients with IS, and the prevalence of incidental intracranial aneurysms was 6.1%; the presence of incidental intracranial aneurysms in IS patients was more evident in female and older patients ( 17 ).…”

“…Moreover, they found that IS patients presented with a higher prevalence of intracranial aneurysms than the general population, while IS patients who had intracranial aneurysms did not have an effect on functional outcomes ( 18 ). Wu et al retrospectively collected data from 4,033 patients with IS and found that 6.5% of patients presented with UIA, and incidental UIA was not associated with the prognosis of IS ( 19 ). However, the risk factors and predictive models for UIA in patients with IS remain unclear.…”

Circular RNA expression alteration and bioinformatics analysis in patients with acute cerebral infarction injury

“…[ 3 ] It is complicated with respiratory, circulatory, blood, and other system diseases or has a history of corresponding diseases in the past.…”

“…The results show that [ 1 ]: The most significant and meaningful terms in biological process are metabolic process and RNA splicing, which describe a series of biological events ( Figure 5a-d ) [ 2 ]. As far as cell components are concerned, the most important enrichment and meaningful terms are intracellular parts and complexes, describing cell components ( Figure 6a-d ) [ 3 ]. As far as molecular function is concerned, the most important enrichment and meaningful term is the binding event, which indicates the function at the molecular level ( Figure 7a-d ).…”

“…ACI is most frequently caused by hypoxia and ischemia of brain tissue, leading to a nerve function damage [ 2 ]. Currently, our understanding is rather limited regarding the molecular mechanisms leading to the development of ACI, and we mainly rely on imaging and hemodynamics to evaluate the condition and prognosis [ 3–5 ]. Therefore, better understanding of disease-associated changes at a molecular level is necessary in order to find potential intervention or treatment targets.…”