Incidental Thyroid Carcinoma in Thyrotoxic Patients Treated by Surgery

Çakır, Mehtap; Arıcı, Cumhur; Alakuş, Hüseyin; Altunbaş, Hasan; Balcı, Mustafa Kemal; Karayalçın, Ümit

doi:10.1159/000096357

Cited by 23 publications

(11 citation statements)

References 39 publications

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“…These data suggest that Del403 is likely a new active TSHR mutation, but further in vitro studies are required. With respect to the prevalence of a germline polymorphism of Asp727Glu in the TSHR gene and the presence of incidental papillary thyroid carcinoma in thyroid surgical specimens, our results confirm the findings of previous studies [32][33][34].…”

Section: Acknowledgmentssupporting

confidence: 89%

Prevalence of TSH Receptor and Gs.ALPHA. Mutations in 45 Autonomously Functioning Thyroid Nodules in Japan

et al. 2009

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Abstract. Somatic mutations of the thyrotropin receptor (TSHR) gene and the gene encoding the α subunit of the stimulatory GTP-binding protein (Gsα) are the main cause for autonomously functioning thyroid nodules (AFTN) in iodine-deficient regions of the world. In iodine-sufficient regions, including Japan, the genetic relevance of AFTN is unclear. In a series of 45 Japanese subjects with AFTN, exons 9 and 10 of the TSHR and exons 7-10 of Gsα, where the activating mutations have been found, were analyzed using direct sequencing. We found 29 somatic mutations: 22 in the TSHR gene and 7 in the Gsα gene. The most frequent mutation in TSHR was Met453Thr (10 cases), followed by clustered residues from codons 630 through 633 on TSHR (7 cases). Mutations of Gsα were detected at codon 201 in 5 cases and at codon 227 in 2 cases. No patients had coexistent TSHR and Gsα mutations in the same nodule. All mutated residues but one, which was deleted at codon 403 on the TSHR gene, are constitutively active. The prevalences of a germline polymorphism of Asp727Glu on the TSHR gene and incidental papillary thyroid carcinoma in thyroid surgical specimens were similar to those reported in other studies. In the present study, more than half of the cases with AFTN had a somatic activating mutation either of the TSHR or Gsα gene, despite their high iodine intake.

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Section: Acknowledgmentssupporting

confidence: 89%

Prevalence of TSH Receptor and Gs.ALPHA. Mutations in 45 Autonomously Functioning Thyroid Nodules in Japan

et al. 2009

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“…This was not surprising. Papillary microcarcinomas, defined as tumours of 1 cm or less, are common incidental findings in a nodular goitre or in the thyroid glands of Graves’ disease 37,38 . In this study they were 2 and 3 mm, respectively, and unlikely to have shown any clinical symptoms.…”

Section: Discussionmentioning

confidence: 60%

Immunohistochemical staining for thyroid peroxidase (TPO) of needle core biopsies in the diagnosis of scintigraphically cold thyroid nodules

Yousaf¹,

Christensen²,

Rasmussen³

et al. 2007

Clinical Endocrinology

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Background Cold thyroid nodules are common, in particular in iodine-deficient areas, but only a minority of them are malignant requiring surgery. Thyroid peroxidase (TPO) immunostaining of fine-needle aspiration cytology (FNAC) material has proven helpful in diagnosing cells from malignant lesions, but the procedure has its limitations in a routine setting. Purpose To improve diagnosis and reduce surgery rate, the FNAC procedure was replaced by needle core biopsy (NCB), which was routinely stained for TPO by the monoclonal antibody mAb 47. Materials and methods During a 5-year period 427 consecutive patients with a cold thyroid nodule were evaluated by ultrasound-guided NCB, which had been routinely stained for TPO in an automated immunostainer. Sensitivity and specificity and predictive values of the TPO immunostaining were estimated, based on the final diagnosis obtained from surgical resection. Results The majority of nodules with benign NCB diagnosis were not surgically removed, and thus a subgroup of 140 operated nodules formed the basis for the calculations. Sensitivity and specificity for benign and malignant lesions were 100% if the oxyphilic variant of adenomas and minimally invasive follicular carcinomas were excluded. By inclusion of these, the values fell to 89% and 97%, respectively. The predictive value of a positive test was 96% and the predictive value of a negative test was 97%. Conclusion TPO immunostaining was found to be a valuable adjunct to morphology in the diagnosis of cold thyroid nodules of the nonoxyphilic type.

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“…Concerning associated thyroid diseases, multinodular goiter appear to have the highest incidence, from 4% to 17% (43,44). In Graves, the incidence varies from 0.5% to 1.8% (45)(46)(47)(48)(49). The incidence of carcinomas in the cervicomediastinal goiter compared with benign thyroid cervical-mediastinum disease, is around 12.1% (50,51).…”

Section: Discussionmentioning

confidence: 99%

Incidental thyroid carcinomas. A retrospective study

Maturo¹

2017

GCHIR

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Incidental Thyroid Carcinoma in Thyrotoxic Patients Treated by Surgery

Cited by 23 publications

References 39 publications

Prevalence of TSH Receptor and Gs.ALPHA. Mutations in 45 Autonomously Functioning Thyroid Nodules in Japan

Prevalence of TSH Receptor and Gs.ALPHA. Mutations in 45 Autonomously Functioning Thyroid Nodules in Japan

Immunohistochemical staining for thyroid peroxidase (TPO) of needle core biopsies in the diagnosis of scintigraphically cold thyroid nodules

Incidental thyroid carcinomas. A retrospective study

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