Incidental Thyroid Carcinoma

Abstract

the result of this study show, a high frequency of ITC (20.3 %). ITC was more frequent in euthyroid patients (P value 0.029). Incidence of ITC is not significantly different between patients presenting with SNG from those with MNG (P value 0.262). Papillary carcinoma was the commonest ITC (97.4 %) and follicular variant (16/38) was found more often than micropapillary variant (3/38).

Comparison of clinicopathological features in incidental and nonincidental papillary thyroid carcinomas in 308 patients

“…In our study, IPTCs were more common in female patients and the mean age of patients was 51.3 years, which was similar to the data reported in the meta-analysis. Some studies have stated that FVPTC was the most common histological variant in IPTCs [7,10,17,21], whereas other studies indicated that CVPTC was the most common variant in IPTCs [15,18], as in our study. One of the studies was performed in a nearby geographic region and reported similar results to our study by declaring the most common histology as CVPTC in IPTCs [18].…”

“…Thus, in terms of the most significant prognostic markers, including LNM and ETE, the results of the present study may reveal that female patients with a diagnosis of IPTC smaller than 5 mm with conventional histology and infiltrative tumour borders should be managed very carefully for the possibility of LNM. An overview of some of the previous studies, including IPTCs (not all incidental thyroid carcinomas), and of the present study is given in Table V [5,10,11,17,18,27,28,37,38,39]. Based on the profile documented in Table V, IPTCs may constitute 3% to 54% of PTCs, and they may occur more commonly in female patients older than 45 years with a background of MNH.…”

“…The incidence of IPTCs has been examined in surgical specimens and in autopsy series in several previous studies. The reported rates of IPTCs, either microcarcinomas or carcinomas larger than 10 mm, ranged between 2.3% and 75.5% in different series from various geographic regions [5,6,7,10,12 27,28]. The informed incidence of IPTCs in autopsy series ranged between 1% and 35.6% [29,30,31,32].…”

“…This increase is associated with the improvement of imaging procedures, including ultrasound (US) [1] and ultrasound-guided fine-needle aspiration (USFNA) [2], and clinical management of thyroid nodules [1,3,4]. However, preoperatively unsuspected PTCs -namely, incidental PTCs (IPTCs), and particularly, microcarcinomas -comprise a significant portion of this increased incidence, with reported percentages between 3% and 75.5% [3,5,6,7,8,9,10,11,12]. IPTCs can be defined as PTCs that are identified on pathological examination [via fine-needle aspiration (FNA) or histopathological evaluation] without any clinical or radiological suspicion for malignancy [3,13].…”

Incidental thyroid carcinomas. A retrospective study

“…It is then argued if incidental carcinomas also include the carcinomas discovered at the definitive histological examination, after total thyroidectomy for multinodular goiter (26)(27)(28)(29)(30)(31)(32)(33) or during treatment of an unrelated head and neck cancer (34). There is no doubt that the latter are also an occasional finding within parenchymas where multinodularity and poor response to medical therapy become responsible for an inalienable surgical choice.…”