Incidental testicular cancers that subsequently developed in oligozoospermic and azoospermic patients: report of three cases

Kanto, Satoru; Takahashi, Katsuharu; Maehara, Ikuo; Fukuzaki, Atsushi; Kyono, Koichi; Arai, Yoichi

doi:10.1016/j.fertnstert.2007.01.029

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…The rate of seminoma was 1.1% (3/272) in this study and 0.7% (1/145) in the report of Mancini et al 4 . Kanto et al., 5 who followed 460 patients with male infertility and reported that 0.5% (1/174) of patients with azoospermia developed seminoma. The incidence of testicular tumors is estimated to be 0.001% in the general population for all races, 6 but the incidence in Asian populations is thought to be about 1/3 that for other races.…”

Section: Age Chromosome Test Testicular Volume (Ml) Hormonal Level Tu...supporting

confidence: 52%

Patients with azoospermia have a higher incidence of testicular tumors

et al. 2023

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Section: Age Chromosome Test Testicular Volume (Ml) Hormonal Level Tu...supporting

confidence: 52%

Patients with azoospermia have a higher incidence of testicular tumors

et al. 2023

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“…This hypothesis is further supported by the higher incidence of testicular cancer detected in men with abnormal semen characteristics (Jacobsen et al. , 2000; Kanto et al. , 2007).…”

Section: Discussionmentioning

confidence: 77%

Assessment of sperm quality, DNA integrity and cryopreservation protocols in men diagnosed with testicular and systemic malignancies

Said¹,

Téllez²,

Evenson³

et al. 2009

Andrologia

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Men diagnosed with malignancy are often referred for semen banking to preserve their fertility prior to cancer treatment. The chances of cancer patients for achieving future fecundity will be determined by the sperm quality including the integrity of the genomic material in the frozen samples. The objectives of this study were to compare the sperm quality and DNA integrity in men diagnosed with testicular and systemic malignancies before receiving treatment and to identify the optimum cryopreservation protocol for their samples including a remote semen collection option. In comparison with fertile donors, patients with testicular malignancies had significantly lower sperm concentration, while both testicular and systemic malignancy patients had significantly lower sperm motility and cryosurvival rates. In addition, the SCSA defined DNA fragmentation index was significantly higher in patients with testicular and systemic malignancies compared with fertile donors. It was noted that the extent of deterioration in sperm quality and DNA integrity seen in cancer patients did not reach the previously defined statistical threshold for impaired fertility. Freezing spermatozoa with the seminal plasma offers the highest protection against cryo-injury. Nevertheless, remote semen collection can still be used as it yields adequate results.

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“…Male infertility has previously been linked to an excess risk of cancer, including testicular and prostate cancer 5,6. Prostate cancer represents 33% of all male cancers and hence may influence overall survival in men with infertility 7.…”

Section: Introductionmentioning

confidence: 99%

<p>Mortality in 43,598 men with infertility – a Swedish nationwide population-based cohort study</p>

Lundberg

Johansson

Ludvigsson

2019

CLEP

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Background Previous studies indicate a higher risk of comorbidity in men with infertility; however, research on mortality is scarce and the few studies that do exist have rarely differentiated between infertility and infertility-related diagnoses. Objective To examine mortality in men with an infertility or infertility-related diagnosis. Design, setting, and participants Population-based cohort study of men born in 1944–1992 in Sweden. We used Cox regression estimated hazard ratios (HRs) for infertility while adjusting for number of children, education, year of birth, country of birth, diabetes, hypertension, liver disease and end-stage renal disease. In all, 43,598 men with a diagnosis of infertility and 57,733 men with an infertility-related diagnosis were compared with 2,762,254 men (reference group) without such diagnoses. Outcome measures All-cause and cause-specific mortality at age 20 to 69 years. Results and limitations The 2,863,585 men in the study were followed for a median time of 22.0 years. During follow-up, 439 men with a diagnosis of infertility died, corresponding to a crude incidence rate of 1.56 deaths per 1,000 person-years. These figures can be compared with 1,400 deaths in men with an infertility-related diagnosis (1.96 deaths/1,000 person-years) and 99,463 deaths in reference individuals (2.17 deaths/1,000 person-years). Overall, men with a diagnosis of infertility did not have a higher risk of death (adjusted [a]HR=0.98; 95% confidence interval [95% CI]=0.89–1.08), but had a higher risk of death before age 30 (20–29 years) (aHR=3.26; 95% CI=2.42–4.41). This early excess mortality was largely explained by cancer diagnosed before infertility. Having an infertility-related diagnosis was associated with death (aHR=1.23; 95% CI=1.17–1.30). Limitations include the lack of general screening for infertility in Sweden and the lack of information on semen parameters. Conclusion Men with a diagnosis of infertility are not at a higher risk of death than the general population, although having a diagnosis related to infertility may be linked to a higher risk of death. Patient summary Men with a diagnosis of infertility do not seem to have a higher risk of death though an infertility-related diagnosis in men is associated with the risk of death.

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Incidental testicular cancers that subsequently developed in oligozoospermic and azoospermic patients: report of three cases

Cited by 7 publications

References 12 publications

Patients with azoospermia have a higher incidence of testicular tumors

Patients with azoospermia have a higher incidence of testicular tumors

Assessment of sperm quality, DNA integrity and cryopreservation protocols in men diagnosed with testicular and systemic malignancies

<p>Mortality in 43,598 men with infertility – a Swedish nationwide population-based cohort study</p>

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