Incidental prostate cancer in transurethral resection of prostate specimens in men aged up to 65 years

Perera, Marlon; Lawrentschuk, Nathan; Perera, Nayomi; Bolton, Damien; Clouston, David

doi:10.1016/j.prnil.2015.10.016

Cited by 24 publications

(15 citation statements)

References 29 publications

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“…Data management : The data were double entered and cleaned using Epi data version 3.1, and STATA version 11 (Stata Corp LP, college station, TX) was used for analysis. In this study, histological result with prostatic carcinoma in <5% of the biopsy was recorded as T1a while those with >5% were recorded as T1b ( 15 ). The Gleason score of 2–4 was coded as low grade (well differentiated), while score of 5–7 and 8–10 were coded as moderate (moderately differentiated) and high grade (poorly differentiated) respectively as used in other study ( 13 ).…”

Section: Methodsmentioning

confidence: 77%

Prevalence and associated factors of incidentally diagnosed prostatic carcinoma among patients who had transurethral prostatectomy in Tanzania: a retrospective study

Gunda¹,

Kido²,

Kilonzo³

et al. 2018

Ethiop J Health Sci

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Background Prostatic carcinoma carries a high morbidity and mortality if it is not diagnosed early. In resource limited countries, patients are at increased risk of being diagnosed late as they are operated for presumed benign prostatic hyperplasia. The information on the magnitude and risk factors of this problem in our setting could assist in the overall optimization of care of patients at risk. Methods A retrospective study of patients who underwent prostatectomy for presumed benign prostatic enlargement was done at Bugando University Hspital in Tanzania. Patients' age, creatinine levels, urological Ultrasound, prostate specific antigen and Biopsy results were analyzed using STATA 11. The prevalence of incidental prostatic cancer was calculated and logistic regression was done for factors associated with incidental prostatic cancer. Results In total, 152 patients were included in this study. The median age was 69 (SD 9.4) years, 16 (10.53%,) and 49 (32.24%) participants had Hydronephrosis and elevated creatinine levels respectively. Eighty six (58.56%) patients had PSA >10 ng/mL and in total; 33 (21.71%) had incidental prostatic carcinoma. The incidental prostatic carcinoma was independently associated with age of 70– 80years (AOR=2.8, p = 0.013) and PSA levels >10ng/mL (AOR=3.2, p=0.014). Conclusions The prevalence of incidental prostatic carcinoma is high among patients undergoing transurethral prostatectomy for presumed benign prostatic hyperplasia in Tanzania with increased risk at age of 70–80 years and among those with PSA >10ng/mL. A national awareness campaign coupled with focused screening of patients above 60 years could increase the detection rate of prostatic carcinoma and reduce the magnitude of incidental diagnosis of this disease.

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Section: Methodsmentioning

confidence: 77%

Prevalence and associated factors of incidentally diagnosed prostatic carcinoma among patients who had transurethral prostatectomy in Tanzania: a retrospective study

Gunda¹,

Kido²,

Kilonzo³

et al. 2018

Ethiop J Health Sci

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“…However, in PSA era, the rate of detection of incidental prostate cancer on TURP has been reported to be 4.1-16.7%. 9,12,27 Most prostatic cancers arise from peripheral zone and tumors detected exclusively in transitional zone account only for 2-7%. In the present study, prostatic carcinoma was diagnosed in 8 patients (3.26%).…”

Section: Discussionmentioning

confidence: 99%

Histomorphological spectrum of prostatic lesions: a retrospective analysis of transurethral resection of prostate specimens

Sharma

Gandhi

et al. 2017

Int J Res Med Sci

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Background: Prostatic diseases like inflammation, benign prostatic hyperplasia and tumors are important causes of mortality and morbidity in males. The incidence of these lesions increases with advancing age. The second most common cancer among males is prostate cancer, next to lung cancer worldwide. Transurethral resection of prostate (TURP) is most frequently preformed surgical procedure in the clinical practice. The purpose of the study is to evaluate histomorphological spectrum of prostate lesions in TURP specimen with focus on premalignant lesions and incidental carcinomas.Methods: The present study includes 245 cases of TURP specimen from January 2015 to December 2016 received in the post graduate department of pathology, ASCOMS and Hospital. H and E stained sections were examined. The relevant clinical details pertaining to age, clinical complaints and microscopic details were analysed and compared with other similar studies.Results: Of the total 245 TURP specimen, 223 (91.02%) were of nodular hyperplasia, 14 (5.71%) were of prostatic intraepithelial neoplasia and 8 (3.26%) cases were malignant. Benign hyperplasia of prostate (BHP) alone accounted for 91.02% of TURP specimen. Less frequent findings were granulomatous prostatitis in 3.70% and atypical adenomatous hyperplasia (1.22%). All the 8 cases of prostate cancer were incidental carcinoma, 5 of which were poorly differentiated and 3 were moderately differentiated adenocarcinoma.Conclusions: The present study showed that non-neoplastic lesions of prostate are more common than neoplastic ones. The most frequently encountered prostatic lesion was BHP, commonly seen in the age group of 61-70 years. The malignant lesions were common among the males of more than 60 years. TURP can be helpful in early identification of premalignant lesions and incidental prostate cancer which can improve the treatment outcome of patients.

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“…However in a study conducted by Marlon Perera, prostate cancer was diagnosed in 13.4% of the younger group and 28.7% in the older group. 17 The younger group had a higher proportion of low-volume disease (pT1a). Of the diagnosed prostate cancers, the 92.2% were of acinar adenocarcinoma subtype, with similar proportions between subgroups.…”

Section: 12mentioning

confidence: 97%

Incidence of Carcinoma Prostate in Transurethral Resection Specimen in a Teaching Hospital of Nepal

Thapa¹,

Shris²,

Pokharel³

et al. 2016

J Lumbini Med Coll

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Introduction: As suggested through several autopsy studies there is a high prevalence of latent prostate cancer in the population. A much smaller proportion of prostate cancer is detected because of clinical symptoms. This study was done to identify the rates of incidentally detected prostate cancer in patients undergoing surgical management of Benign Prostatic Hyperplasia (BPH) in our centre. Methods: A retrospective review was done on all transurethral resections of the prostate (TURP) cases from May 2014 to May 2015 at a single tertiary care institution. One hundred and three men, aged 40 to 88 year, underwent TURP and their specimens were sent for the histopathological analysis. Results: Five (4.85%) patients were diagnosed with the prostate cancer. All the five patients had Gleason score of seven or more. Two patients had moderately differentiated adenocarcinoma with Gleason score of seven. Three patients had poorly differentiated adenocarcinoma with Gleason score of eight or above. The Prostate cancer was seen only in the age group above 65 years but it was not statistically significant. Conclusion: Our series demonstrated that 4.85% of patients had latent prostate cancer. It occurs mainly in men above 65 years of age though this was not statistically significant.

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Incidental prostate cancer in transurethral resection of prostate specimens in men aged up to 65 years

Cited by 24 publications

References 29 publications

Prevalence and associated factors of incidentally diagnosed prostatic carcinoma among patients who had transurethral prostatectomy in Tanzania: a retrospective study

Prevalence and associated factors of incidentally diagnosed prostatic carcinoma among patients who had transurethral prostatectomy in Tanzania: a retrospective study

Histomorphological spectrum of prostatic lesions: a retrospective analysis of transurethral resection of prostate specimens

Incidence of Carcinoma Prostate in Transurethral Resection Specimen in a Teaching Hospital of Nepal

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